PMID- 30179691
OWN - NLM
STAT- In-Data-Review
LR  - 20181014
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Linking)
VI  - 132
DP  - 2018 Nov
TI  - Effectiveness of antiarrhythmic drugs for shockable cardiac arrest: A systematic 
      review.
PG  - 63-72
LID - S0300-9572(18)30807-4 [pii]
LID - 10.1016/j.resuscitation.2018.08.025 [doi]
AB  - PURPOSE: The purpose of this systematic review is to provide up-to-date evidence 
      on effectiveness of antiarrhythmic drugs for shockable cardiac arrest to help
      inform the 2018 International Liaison Committee on Resuscitation Consensus on
      Science with Treatment Recommendations. METHODS: A search was conducted in
      electronic databases Medline, Embase, and Cochrane Library from inception to
      August 15, 2017. RESULTS: Of the 9371 citations reviewed, a total of 14 RCTs and 
      17 observational studies met our inclusion criteria for adult population and only
      1 observational study for pediatric population. Based on RCT level evidence for
      adult population, none of the anti-arrhythmic drugs showed any difference in
      effect compared with placebo, or with other anti-arrhythmic drugs for the
      critical outcomes of survival to hospital discharge and discharge with good
      neurological function. For the outcome of return of spontaneous circulation, the 
      results showed a significant increase for lidocaine compared with placebo (RR =
      1.16; 95% CI, 1.03-1.29, p = 0.01). CONCLUSION: The high level evidence
      supporting the use of antiarrhythmic drugs during CPR for shockable cardiac
      arrest is limited and showed no benefit for critical outcomes of survival at
      hospital discharge, survival with favorable neurological function and long-term
      survival. Future high quality research is needed to confirm these findings and
      also to evaluate the role of administering antiarrhythmic drugs in children with 
      shockable cardiac arrest, and in adults immediately after ROSC.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Ali, Muhammad Usman
AU  - Ali MU
AD  - McMaster Evidence Review and Synthesis Centre, McMaster University, 1280 Main St.
      W., McMaster Innovation Park, Room 207A, Hamilton, Ontario, L8S 4K1, Canada;
      Department of Health Research Methods, Evidence and Impact, Faculty of Health
      Sciences, McMaster University, Room HSC-2C, 1200 Main Street West, Hamilton,
      Ontario, L8N 3Z5, Canada.
FAU - Fitzpatrick-Lewis, Donna
AU  - Fitzpatrick-Lewis D
AD  - School of Nursing, Faculty of Health Sciences, McMaster University, Health
      Sciences Centre Room HSC-3N25F, 1280 Main Street West, Hamilton, Ontario, L8S
      4K1, Canada.
FAU - Kenny, Meghan
AU  - Kenny M
AD  - McMaster Evidence Review and Synthesis Centre, McMaster University, 1280 Main St.
      W., McMaster Innovation Park, Room 207A, Hamilton, Ontario, L8S 4K1, Canada;
      Department of Health Research Methods, Evidence and Impact, Faculty of Health
      Sciences, McMaster University, Room HSC-2C, 1200 Main Street West, Hamilton,
      Ontario, L8N 3Z5, Canada.
FAU - Raina, Parminder
AU  - Raina P
AD  - McMaster Evidence Review and Synthesis Centre, McMaster University, 1280 Main St.
      W., McMaster Innovation Park, Room 207A, Hamilton, Ontario, L8S 4K1, Canada;
      Department of Health Research Methods, Evidence and Impact, Faculty of Health
      Sciences, McMaster University, Room HSC-2C, 1200 Main Street West, Hamilton,
      Ontario, L8N 3Z5, Canada.
FAU - Atkins, Dianne L
AU  - Atkins DL
AD  - Stead Family Department of Pediatrics, Carver College of Medicine, University of 
      Iowa, Iowa City, IA, 52242, USA.
FAU - Soar, Jasmeet
AU  - Soar J
AD  - Southmead Hospital, Bristol, BS10 5NB, UK.
FAU - Nolan, Jerry
AU  - Nolan J
AD  - University of Bristol and Royal United Hospital, Bath, BA1 3NG, UK.
FAU - Ristagno, Giuseppe
AU  - Ristagno G
AD  - IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
FAU - Sherifali, Diana
AU  - Sherifali D
AD  - McMaster Evidence Review and Synthesis Centre, McMaster University, 1280 Main St.
      W., McMaster Innovation Park, Room 207A, Hamilton, Ontario, L8S 4K1, Canada;
      School of Nursing, Faculty of Health Sciences, McMaster University, Health
      Sciences Centre Room HSC-3N25F, 1280 Main Street West, Hamilton, Ontario, L8S
      4K1, Canada. Electronic address: dsherif@mcmaster.ca.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180901
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
OTO - NOTNLM
OT  - Antiarrhythmic drugs
OT  - Cardiac arrest
OT  - Good neurological function
OT  - Pulseless ventricular tachycardia or ventricular fibrillation
OT  - Return of spontaneous circulation
EDAT- 2018/09/05 06:00
MHDA- 2018/09/05 06:00
CRDT- 2018/09/05 06:00
PHST- 2018/06/28 00:00 [received]
PHST- 2018/08/17 00:00 [revised]
PHST- 2018/08/23 00:00 [accepted]
PHST- 2018/09/05 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2018/09/05 06:00 [entrez]
AID - S0300-9572(18)30807-4 [pii]
AID - 10.1016/j.resuscitation.2018.08.025 [doi]
PST - ppublish
SO  - Resuscitation. 2018 Nov;132:63-72. doi: 10.1016/j.resuscitation.2018.08.025. Epub
      2018 Sep 1.