PMID- 30173404
OWN - NLM
STAT- MEDLINE
DCOM- 20181219
LR  - 20181219
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 275
IP  - 11
DP  - 2018 Nov
TI  - Functional identification of abductor and adductor branches for laryngeal
      transplantation.
PG  - 2813-2816
LID - 10.1007/s00405-018-5112-3 [doi]
AB  - PURPOSE: This is a feasibility study of functional identification of the abductor
      and adductor recurrent laryngeal nerve branches, which could be used in the
      donor's larynx for functional laryngeal transplantation. METHODS: The study was
      performed on swine (n = 3) and human (n = 4) models of a donor larynx. The
      recurrent laryngeal nerve and its branches were found. Using stimulator, abductor
      and adductor branches were identified, and glottis closing and opening were
      captured with an endoscope. RESULTS: The result was positive if two ENT
      specialists noticed at least one adduction and one abduction movement in the same
      subject. It was obtained in three out of three swine and three out of four
      humans. CONCLUSIONS: This study shows a way of reinnervation of a transplanted
      larynx which might result in a functional organ. It describes the first step of
      the procedure: functional identification of the abductor and adductor branches of
      the recurrent laryngeal nerve in the donor before the larynx is excised for
      transplantation.
FAU - Migacz, Ewa
AU  - Migacz E
AD  - Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical
      University of Warsaw, 19/25 Stepinska Street, 00-739, Warsaw, Poland.
FAU - Howard, David
AU  - Howard D
AD  - Royal National Throat, Nose and Ear Hospital, 330 Gray's Inn Road, London, UK.
AD  - Imperial NHS Trust Hospitals, London, UK.
FAU - Gajewski, Zdzislaw
AU  - Gajewski Z
AD  - Department of Large Animal Diseases with the Clinic, Faculty of Veterinary
      Medicine, Warsaw University of Life Sciences, Nowoursynowska 100, 02-797, Warsaw,
      Poland.
FAU - Siewruk, Katarzyna
AU  - Siewruk K
AD  - Department of Large Animal Diseases with the Clinic, Faculty of Veterinary
      Medicine, Warsaw University of Life Sciences, Nowoursynowska 100, 02-797, Warsaw,
      Poland.
FAU - Kukwa, Wojciech
AU  - Kukwa W
AUID- ORCID: http://orcid.org/0000-0002-2982-4412
AD  - Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical
      University of Warsaw, 19/25 Stepinska Street, 00-739, Warsaw, Poland.
      wojciechkukwa@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180901
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Animals
MH  - Feasibility Studies
MH  - Glottis/*physiology
MH  - Humans
MH  - Laryngeal Muscles/*innervation
MH  - Laryngeal Neoplasms/*surgery
MH  - Larynx/*transplantation
MH  - Recurrent Laryngeal Nerve/*surgery
MH  - Swine
OTO - NOTNLM
OT  - Airway stenosis/reconstruction
OT  - Laryngeal reinnervation
OT  - Larynx
OT  - Microvascular reconstruction and transplant surgery
EDAT- 2018/09/03 06:00
MHDA- 2018/12/20 06:00
CRDT- 2018/09/03 06:00
PHST- 2018/08/01 00:00 [received]
PHST- 2018/08/27 00:00 [accepted]
PHST- 2018/09/03 06:00 [pubmed]
PHST- 2018/12/20 06:00 [medline]
PHST- 2018/09/03 06:00 [entrez]
AID - 10.1007/s00405-018-5112-3 [doi]
AID - 10.1007/s00405-018-5112-3 [pii]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2018 Nov;275(11):2813-2816. doi:
      10.1007/s00405-018-5112-3. Epub 2018 Sep 1.