PMID- 30155606
DCOM- 20190219
LR  - 20190320
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 50
IP  - 11
DP  - 2018 Nov
TI  - Serum vitamin D level may be a novel potential risk factor for premature
      ejaculation: a comparative study.
PG  - 1975-1980
LID - 10.1007/s11255-018-1975-x [doi]
AB  - PURPOSE: To compare serum level of vitamin D [25(OH)D] in patients with life-long
      premature ejaculation (LPE) versus healthy controls. METHODS: Healthy married
      potent males were recruited from February 2017 to January 2018. Group A included 
      40 patients suffering from LPE who were compared versus 40 healthy controls
      (Group B). Participants suffering from hormonal disorders, obesity, neurological,
      psychological, or chronic diseases or taking medications that may affect
      ejaculatory function, serum level of vitamin D, or the accuracy of intra-vaginal 
      ejaculation latency time (IELT) were excluded. LPE was self-reported by the
      patients with subsequent feelings of frustration and measured by premature
      ejaculation diagnostic tool (PEDT) and IELT using stopwatch handled by their
      partners. 25(OH)D was measured by obtaining 2 ml of venous blood. Statistical
      analysis was performed using Student t, Mann-Whitney, Chi square tests, logistic 
      regression analysis, and Spearman correlation. RESULTS: Sixteen (20%)
      participants had vitamin D insufficiency/deficiency. All of them were in PE
      group. 25(OH)D correlated significantly with IELT (r(2) = 0.349; p < 0.001) and
      PEDT (r(2) = 0.425; p < 0.001). There was no statistically significant difference
      in age (p = 0.341), BMI (p = 1) or IIEF-5 (p = 0.408) in both groups. 25(OH)D was
      significantly lower in patients than controls (35.75 vs. 58.92 ng/ml, p < 0.001).
      ROC analysis revealed that the best cut-off value of 25(OH)D to detect patients
      suffering from LPE was 50.65 ng/ml with a sensitivity and specificity of 85% for 
      both. 25(OH)D remained a significant risk factor for LPE in the logistic
      regression analysis (p < 0.001). CONCLUSIONS: The current study showed that
      vitamin D has significant association with LPE and correlates significantly with 
      IELT and PEDT.
FAU - Abd El Aal, Alaa Mohamed
AU  - Abd El Aal AM
AD  - Andrology & STDs Department, Kasr Alainy Faculty of Medicine, Cairo University,
      Cairo, Egypt.
FAU - GamalEl Din, Sameh Fayek
AU  - GamalEl Din SF
AD  - Andrology & STDs Department, Kasr Alainy Faculty of Medicine, Cairo University,
      Cairo, Egypt.
FAU - Rashed, Laila Ahmed
AU  - Rashed LA
AD  - Biochemistry Department, Kasr Alainy Faculty of Medicine, Cairo University,
      Cairo, Egypt.
FAU - Tawfik, Abd El Rahman Bakry
AU  - Tawfik AERB
AD  - Ministry of Health, Cairo, Egypt.
FAU - ElSheemy, Mohammed Said
AU  - ElSheemy MS
AD  - Urology Department, Kasr Alainy Faculty of Medicine, Kasr Al-Ainy Hospitals,
      Cairo University, Cairo, Egypt.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180828
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Humans
MH  - Male
MH  - Premature Ejaculation/*blood/*etiology
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Vitamin D/*blood
MH  - Vitamin D Deficiency/complications/diagnosis/*epidemiology
MH  - Young Adult
OT  - Lifelong premature ejaculation
OT  - Serotonin
OT  - Serum vitamin D
OT  - Tryptophan hydroxylase
OT  - Vitamin D deficiency
EDAT- 2018/08/30 06:00
MHDA- 2019/03/21 06:00
CRDT- 2018/08/30 06:00
PHST- 2018/07/14 00:00 [received]
PHST- 2018/08/23 00:00 [accepted]
PHST- 2018/08/30 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/08/30 06:00 [entrez]
AID - 10.1007/s11255-018-1975-x [doi]
AID - 10.1007/s11255-018-1975-x [pii]
PST - ppublish
SO  - Int Urol Nephrol. 2018 Nov;50(11):1975-1980. doi: 10.1007/s11255-018-1975-x. Epub
      2018 Aug 28.