PMID- 30151831
OWN - NLM
STAT- MEDLINE
DCOM- 20190313
LR  - 20190313
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 128
IP  - 11
DP  - 2018 Nov
TI  - Permeability and Weibel-Palade Bodies of the Blood Vessels in the Human Vocal
      Fold Mucosa.
PG  - 2588-2592
LID - 10.1002/lary.27431 [doi]
AB  - OBJECTIVES: Transendothelial exchange and permeability of the capillaries in
      Reinke space (the superficial layer of the lamina propria) of the vocal fold
      mucosa affect physiological and pathological conditions of the human vocal fold
      mucosa. The mechanism of permeability and Weibel-Palade bodies of the blood
      vessels in the human vocal fold mucosa were investigated using electron
      microscopy. STUDY DESIGN: Histologic analysis of the human vocal fold. METHODS:
      Six normal human vocal folds (three adults and three newborns) obtained from
      autopsy cases and three human vocal folds with Reinke edema from surgical
      specimens were investigated under transmission electron microscopy. RESULTS:
      There were three possible capillary wall transport systems related to the
      permeability of the blood vessels in the vocal fold mucosa: 1) Fenestra
      transport, plasma exuded from the capillaries into surrounding tissue via the
      fenestration with or without a diaphragm; 2) vesicular transport (transcellular
      transport via vesicles), the use of vesicles to ferry fluid and solutes across
      endothelial cells; and 3) junctional transport (intercellular transport),
      molecules passed through intercellular gaps between endothelial cells.
      Weibel-Palade bodies were present in the cytoplasm of endothelial cells both in
      adults and newborns. They were present in high numbers in the cytoplasm of
      endothelial cells, with intercellular transport in the vocal folds with Reinke
      edema. CONCLUSION: There were three types of mechanisms for the permeability of
      the blood vessels in the human vocal fold mucosa. Some physiologically active
      substances, such as histamine produced by Weibel-Palade bodies, may adversely
      influence the permeability of the blood vessels. LEVEL OF EVIDENCE: NA.
      Laryngoscope, 2588-2592, 2018.
CI  - (c) 2018 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Sato, Kiminori
AU  - Sato K
AUID- ORCID: 0000-0001-5415-0176
AD  - Department of Otolaryngology-Head and Neck Surgery, Kurume University School of
      Medicine, Kurume, Japan.
FAU - Chitose, Shun-Ichi
AU  - Chitose SI
AUID- ORCID: 0000-0002-9307-2331
AD  - Department of Otolaryngology-Head and Neck Surgery, Kurume University School of
      Medicine, Kurume, Japan.
FAU - Sato, Kiminobu
AU  - Sato K
AUID- ORCID: 0000-0001-6537-4490
AD  - Department of Otolaryngology-Head and Neck Surgery, Kurume University School of
      Medicine, Kurume, Japan.
FAU - Sato, Fumihiko
AU  - Sato F
AUID- ORCID: 0000-0002-7990-7590
AD  - Department of Otolaryngology-Head and Neck Surgery, Kurume University School of
      Medicine, Kurume, Japan.
FAU - Umeno, Hirohito
AU  - Umeno H
AD  - Department of Otolaryngology-Head and Neck Surgery, Kurume University School of
      Medicine, Kurume, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180827
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adult
MH  - Autopsy
MH  - Capillary Permeability/*physiology
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Laryngeal Edema/physiopathology
MH  - Laryngeal Mucosa/*blood supply
MH  - Male
MH  - Microscopy, Electron
MH  - Vocal Cords/*blood supply
MH  - Weibel-Palade Bodies/*physiology
OTO - NOTNLM
OT  - *Permeability
OT  - *Reinke space
OT  - *Weibel-Palade body
OT  - *adult
OT  - *capillary
OT  - *human vocal fold mucosa
OT  - *larynx
OT  - *newborn
EDAT- 2018/08/29 06:00
MHDA- 2019/03/14 06:00
CRDT- 2018/08/29 06:00
PHST- 2018/02/26 00:00 [received]
PHST- 2018/04/14 00:00 [revised]
PHST- 2018/06/18 00:00 [accepted]
PHST- 2018/08/29 06:00 [pubmed]
PHST- 2019/03/14 06:00 [medline]
PHST- 2018/08/29 06:00 [entrez]
AID - 10.1002/lary.27431 [doi]
PST - ppublish
SO  - Laryngoscope. 2018 Nov;128(11):2588-2592. doi: 10.1002/lary.27431. Epub 2018 Aug 
      27.