PMID- 30145941
OWN - NLM
STAT- MEDLINE
DCOM- 20181012
LR  - 20181012
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 379
IP  - 12
DP  - 2018 Sep 20
TI  - Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients.
PG  - 1107-1117
LID - 10.1056/NEJMoa1808721 [doi]
AB  - BACKGROUND: Lorcaserin, a selective serotonin 2C receptor agonist that modulates 
      appetite, has proven efficacy for weight management in overweight or obese
      patients. The cardiovascular safety and efficacy of lorcaserin are undefined.
      METHODS: We randomly assigned 12,000 overweight or obese patients with
      atherosclerotic cardiovascular disease or multiple cardiovascular risk factors to
      receive either lorcaserin (10 mg twice daily) or placebo. The primary safety
      outcome of major cardiovascular events (a composite of cardiovascular death,
      myocardial infarction, or stroke) was assessed at an interim analysis to exclude 
      a noninferiority boundary of 1.4. If noninferiority was met, the primary
      cardiovascular efficacy outcome (a composite of major cardiovascular events,
      heart failure, hospitalization for unstable angina, or coronary revascularization
      [extended major cardiovascular events]) was assessed for superiority at the end
      of the trial. RESULTS: At 1 year, weight loss of at least 5% had occurred in 1986
      of 5135 patients (38.7%) in the lorcaserin group and in 883 of 5083 (17.4%) in
      the placebo group (odds ratio, 3.01; 95% confidence interval [CI], 2.74 to 3.30; 
      P<0.001). Patients in the lorcaserin group had slightly better values with
      respect to cardiac risk factors (including blood pressure, heart rate, glycemic
      control, and lipids) than those in the placebo group. During a median follow-up
      of 3.3 years, the rate of the primary safety outcome was 2.0% per year in the
      lorcaserin group and 2.1% per year in the placebo group (hazard ratio, 0.99; 95% 
      CI, 0.85 to 1.14; P<0.001 for noninferiority); the rate of extended major
      cardiovascular events was 4.1% per year and 4.2% per year, respectively (hazard
      ratio, 0.97; 95% CI, 0.87 to 1.07; P=0.55). Adverse events of special interest
      were uncommon, and the rates were generally similar in the two groups, except for
      a higher number of patients with serious hypoglycemia in the lorcaserin group (13
      vs. 4, P=0.04). CONCLUSIONS: In a high-risk population of overweight or obese
      patients, lorcaserin facilitated sustained weight loss without a higher rate of
      major cardiovascular events than that with placebo. (Funded by Eisai;
      CAMELLIA-TIMI 61 ClinicalTrials.gov number, NCT02019264 .).
FAU - Bohula, Erin A
AU  - Bohula EA
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Wiviott, Stephen D
AU  - Wiviott SD
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - McGuire, Darren K
AU  - McGuire DK
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Inzucchi, Silvio E
AU  - Inzucchi SE
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Kuder, Julia
AU  - Kuder J
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Im, KyungAh
AU  - Im K
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Fanola, Christina L
AU  - Fanola CL
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Qamar, Arman
AU  - Qamar A
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Brown, Conville
AU  - Brown C
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Budaj, Andrzej
AU  - Budaj A
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Garcia-Castillo, Armando
AU  - Garcia-Castillo A
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Gupta, Milan
AU  - Gupta M
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Leiter, Lawrence A
AU  - Leiter LA
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Weissman, Neil J
AU  - Weissman NJ
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - White, Harvey D
AU  - White HD
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Patel, Tushar
AU  - Patel T
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Francis, Bruce
AU  - Francis B
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Miao, Wenfeng
AU  - Miao W
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Perdomo, Carlos
AU  - Perdomo C
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Dhadda, Shobha
AU  - Dhadda S
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Bonaca, Marc P
AU  - Bonaca MP
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Ruff, Christian T
AU  - Ruff CT
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Keech, Anthony C
AU  - Keech AC
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Smith, Steven R
AU  - Smith SR
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Sabatine, Marc S
AU  - Sabatine MS
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
FAU - Scirica, Benjamin M
AU  - Scirica BM
AD  - From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of
      Cardiovascular Medicine, Brigham and Women's Hospital, Boston (E.A.B., S.D.W.,
      J.K., K.I., A.Q., M.P.B., C.T.R., M.S.S., B.M.S.); the Cardiovascular Division,
      University of Texas Southwestern Medical Center, Dallas (D.K.M.); the Section of 
      Endocrinology, Yale School of Medicine, New Haven, CT (S.E.I.); the Department of
      Medicine, University of Minnesota, Minneapolis (C.L.F.); the Partners Clinical
      Research Centre, Nassau, Bahamas (C.B.); the Department of Cardiology,
      Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.);
      Cardiolink Clinical Trials, Monterrey, Mexico (A.G.-C.); McMaster University,
      Brampton, ON (M.G.), and the Division of Endocrinology and Metabolism, St.
      Michael's Hospital, University of Toronto, Toronto (L.A.L.) - both in Canada;
      MedStar Health Research Institute, Hyattsville, MD (N.J.W.); the Cardiology
      Department, Auckland City Hospital, Auckland, New Zealand (H.D.W.); Eisai,
      Woodcliff Lake, NJ (T.P., B.F., W.M., C.P., S.D.); National Health and Medical
      Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.);
      and the Translational Research Institute for Metabolism and Diabetes, Florida
      Hospital and the Sanford-Burnham Institute, Winter Park (S.R.S.).
CN  - CAMELLIA-TIMI 61 Steering Committee and Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT02019264
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180826
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (Benzazepines)
RN  - 637E494O0Z (lorcaserin)
SB  - AIM
SB  - IM
CIN - N Engl J Med. 2018 Sep 20;379(12):1174-1175. PMID: 30145932
CIN - N Engl J Med. 2019 Jan 3;380(1):99. PMID: 30601744
CIN - N Engl J Med. 2019 Jan 3;380(1):99. PMID: 30601745
CIN - N Engl J Med. 2019 Jan 3;380(1):99-100. PMID: 30601746
CIN - BMJ. 2019 Jan 30;364:l464. PMID: 30700410
MH  - Aged
MH  - Anti-Obesity Agents/adverse effects/*therapeutic use
MH  - Aortic Valve Insufficiency/chemically induced
MH  - Benzazepines/adverse effects/*therapeutic use
MH  - Cardiovascular Diseases/chemically induced/*complications/epidemiology
MH  - Diabetes Mellitus, Type 2/complications
MH  - Double-Blind Method
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypertension, Pulmonary/chemically induced
MH  - Hypoglycemia/*chemically induced
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*drug therapy
MH  - Overweight/complications/*drug therapy
MH  - Risk Factors
MH  - Weight Loss/*drug effects
IR  - Fish MP
FIR - Fish, M Polly
IR  - Abrahamsen TE
FIR - Abrahamsen, Timothy E
IR  - Gabovitch D
FIR - Gabovitch, Daniel
IR  - Pricken A
FIR - Pricken, Alexandra
IR  - Baird-Zars V
FIR - Baird-Zars, Vivian
IR  - Murphy SA
FIR - Murphy, Sabina A
IR  - Kanevsky E
FIR - Kanevsky, Estella
IR  - Lowe C
FIR - Lowe, Cheryl
IR  - Fisher N
FIR - Fisher, Nathan
IR  - Zahn L
FIR - Zahn, Leah
IR  - Rodriguez D
FIR - Rodriguez, Dolly
IR  - Gannon J
FIR - Gannon, Joseph
IR  - Andreo JD
FIR - Andreo, John D
IR  - Trindade S
FIR - Trindade, Sarina
IR  - Luthman J
FIR - Luthman, Johan
IR  - Satlin A
FIR - Satlin, Andrew
IR  - Corbalan R
FIR - Corbalan, Ramon
IR  - Dwyer J
FIR - Dwyer, Jamie
IR  - Hamm C
FIR - Hamm, Christian
IR  - Kaplan L
FIR - Kaplan, Lee
IR  - Nicolau JC
FIR - Nicolau, Jose Carlos
IR  - Ophuis TO
FIR - Ophuis, Ton Oude
IR  - Ray K
FIR - Ray, Kauski
IR  - Ruda M
FIR - Ruda, Mikhail
IR  - Spinar J
FIR - Spinar, Jindrich
IR  - Ohman EM
FIR - Ohman, E Magnus
IR  - Connolly H
FIR - Connolly, Heidi
IR  - Douglas P
FIR - Douglas, Pamela
IR  - Montalescot G
FIR - Montalescot, Giles
IR  - Zinman B
FIR - Zinman, Bernard
IR  - Kelsey S
FIR - Kelsey, Sheryl
IR  - Alexanian SM
FIR - Alexanian, Sara M
IR  - Awtry E
FIR - Awtry, Eric
IR  - Bentley-Lewis R
FIR - Bentley-Lewis, Rhonda
IR  - Berger CJ
FIR - Berger, Clifford J
IR  - Croce K
FIR - Croce, Kevin
IR  - Desai A
FIR - Desai, Akshay
IR  - Garg RK
FIR - Garg, Rajesh K
IR  - Gelfand E
FIR - Gelfand, Eli
IR  - Ho C
FIR - Ho, Carolyn
IR  - Leeman DE
FIR - Leeman, David E
IR  - Link MS
FIR - Link, Mark S
IR  - McDonnell ME
FIR - McDonnell, Marie E
IR  - Norden AD
FIR - Norden, Andrew D
IR  - Pande A
FIR - Pande, Ashvin
IR  - Ruberg F
FIR - Ruberg, Frederick
IR  - Rost N
FIR - Rost, Natalia
IR  - Silverman S
FIR - Silverman, Scott
IR  - Singhal A
FIR - Singhal, Aneesh
IR  - Stewart GC
FIR - Stewart, Garrick C
IR  - Amerena J
FIR - Amerena, J
IR  - Arstall M
FIR - Arstall, M
IR  - Colquhoun D
FIR - Colquhoun, D
IR  - Jayasinghe R
FIR - Jayasinghe, R
IR  - Lee A
FIR - Lee, A
IR  - Lehman R
FIR - Lehman, R
IR  - Moses R
FIR - Moses, R
IR  - Proietto J
FIR - Proietto, J
IR  - Purnell P
FIR - Purnell, P
IR  - Waites J
FIR - Waites, J
IR  - Blombery P
FIR - Blombery, P
IR  - Cross D
FIR - Cross, D
IR  - Worthley M
FIR - Worthley, M
IR  - d'Emden M
FIR - d'Emden, M
IR  - Selvanayagam J
FIR - Selvanayagam, J
IR  - Oqueli RE
FIR - Oqueli, R E
IR  - Whelan A
FIR - Whelan, A
IR  - Garrahy P
FIR - Garrahy, P
IR  - de Looze F
FIR - de Looze, F
IR  - Ninio D
FIR - Ninio, D
IR  - Horowitz J
FIR - Horowitz, J
IR  - William M
FIR - William, M
IR  - Suranyi M
FIR - Suranyi, M
IR  - Wittert G
FIR - Wittert, G
IR  - Brown C
FIR - Brown, C
IR  - Gupta M
FIR - Gupta, M
IR  - Le May M
FIR - Le May, M
IR  - Pandey AS
FIR - Pandey, A S
IR  - Vizel S
FIR - Vizel, S
IR  - Labonte R
FIR - Labonte, R
IR  - Beaudry Y
FIR - Beaudry, Y
IR  - Fortin C
FIR - Fortin, C
IR  - Bell A
FIR - Bell, A
IR  - Kouz S
FIR - Kouz, S
IR  - St-Amour E
FIR - St-Amour, E
IR  - Bata I
FIR - Bata, I
IR  - St Maurice F
FIR - St Maurice, F
IR  - Chehayeb R
FIR - Chehayeb, R
IR  - Constance C
FIR - Constance, C
IR  - Wong G
FIR - Wong, G
IR  - Hess A
FIR - Hess, A
IR  - Liutkus J
FIR - Liutkus, J
IR  - Poirier P
FIR - Poirier, P
IR  - Teitelbaum I
FIR - Teitelbaum, I
IR  - Berlingieri J
FIR - Berlingieri, J
IR  - Cha J
FIR - Cha, J
IR  - Hartleib M
FIR - Hartleib, M
IR  - Heffernan M
FIR - Heffernan, M
IR  - Twum-Barima D
FIR - Twum-Barima, D
IR  - Pandith V
FIR - Pandith, V
IR  - Aronson R
FIR - Aronson, R
IR  - Goldenberg R
FIR - Goldenberg, R
IR  - Ajala B
FIR - Ajala, B
IR  - Jain A
FIR - Jain, A
IR  - Ross S
FIR - Ross, S
IR  - Bajaj H
FIR - Bajaj, H
IR  - Khandwala H
FIR - Khandwala, H
IR  - Yared Z
FIR - Yared, Z
IR  - Gupta N
FIR - Gupta, N
IR  - Bedard J
FIR - Bedard, J
IR  - Wharton S
FIR - Wharton, S
IR  - Blouin F
FIR - Blouin, F
IR  - Savard D
FIR - Savard, D
IR  - Shukla D
FIR - Shukla, D
IR  - Cobos J
FIR - Cobos, J
IR  - Godoy G
FIR - Godoy, G
IR  - Perez L
FIR - Perez, L
IR  - Pincetti C
FIR - Pincetti, C
IR  - Saavedra Guajardo V
FIR - Saavedra Guajardo, V
IR  - Varleta P
FIR - Varleta, P
IR  - Conejeros C
FIR - Conejeros, C
IR  - Lanas F
FIR - Lanas, F
IR  - Bayram Llamas E
FIR - Bayram Llamas, E
IR  - Cardona Munoz E
FIR - Cardona Munoz, E
IR  - Garcia R
FIR - Garcia, R
IR  - Garza Ruiz J
FIR - Garza Ruiz, J
IR  - Llamas Esperon G
FIR - Llamas Esperon, G
IR  - Lopez Rosas E
FIR - Lopez Rosas, E
IR  - Melendez Mier G
FIR - Melendez Mier, G
IR  - Ramos G
FIR - Ramos, G
IR  - Garcia-Castillo A
FIR - Garcia-Castillo, A
IR  - Hart H
FIR - Hart, H
IR  - Scott D
FIR - Scott, D
IR  - Ternouth I
FIR - Ternouth, I
IR  - Benatar J
FIR - Benatar, J
IR  - Elliott J
FIR - Elliott, J
IR  - Cutfield R
FIR - Cutfield, R
IR  - Manning P
FIR - Manning, P
IR  - Williams M
FIR - Williams, M
IR  - Ferrier K
FIR - Ferrier, K
IR  - Scott R
FIR - Scott, R
IR  - Fisher N
FIR - Fisher, N
IR  - Wilson S
FIR - Wilson, S
IR  - Leikis R
FIR - Leikis, R
IR  - Nirmalaraj BK
FIR - Nirmalaraj, B K
IR  - Krzyzagorska E
FIR - Krzyzagorska, E
IR  - Miekus P
FIR - Miekus, P
IR  - Bronisz M
FIR - Bronisz, M
IR  - Mirek-Bryniarska E
FIR - Mirek-Bryniarska, E
IR  - Landa K
FIR - Landa, K
IR  - Stasiewski A
FIR - Stasiewski, A
IR  - Zechowicz T
FIR - Zechowicz, T
IR  - Zytkiewicz-Jaruga D
FIR - Zytkiewicz-Jaruga, D
IR  - Korecki J
FIR - Korecki, J
IR  - Ogorek M
FIR - Ogorek, M
IR  - Pawlowicz L
FIR - Pawlowicz, L
IR  - Piepiorka M
FIR - Piepiorka, M
IR  - Skierkowska J
FIR - Skierkowska, J
IR  - Stankiewicz A
FIR - Stankiewicz, A
IR  - Szyprowska E
FIR - Szyprowska, E
IR  - Witek R
FIR - Witek, R
IR  - Bochenek A
FIR - Bochenek, A
IR  - Konczakowski P
FIR - Konczakowski, P
IR  - Wojnowski L
FIR - Wojnowski, L
IR  - Wujkowski M
FIR - Wujkowski, M
IR  - Cymerman K
FIR - Cymerman, K
IR  - Korzeniak R
FIR - Korzeniak, R
IR  - Mader P
FIR - Mader, P
IR  - Miklaszewicz B
FIR - Miklaszewicz, B
IR  - Stachlewski P
FIR - Stachlewski, P
IR  - Goch A
FIR - Goch, A
IR  - Pomiecko W
FIR - Pomiecko, W
IR  - Skorski M
FIR - Skorski, M
IR  - Romanowski L
FIR - Romanowski, L
IR  - Jusiak K
FIR - Jusiak, K
IR  - Budaj A
FIR - Budaj, A
IR  - Laskowska-Derlaga E
FIR - Laskowska-Derlaga, E
IR  - Bijata-Bronisz R
FIR - Bijata-Bronisz, R
IR  - Kazmierczak J
FIR - Kazmierczak, J
IR  - Goldberg R
FIR - Goldberg, R
IR  - Henderson D
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EDAT- 2018/08/28 06:00
MHDA- 2018/10/13 06:00
CRDT- 2018/08/28 06:00
PHST- 2018/08/28 06:00 [pubmed]
PHST- 2018/10/13 06:00 [medline]
PHST- 2018/08/28 06:00 [entrez]
AID - 10.1056/NEJMoa1808721 [doi]
PST - ppublish
SO  - N Engl J Med. 2018 Sep 20;379(12):1107-1117. doi: 10.1056/NEJMoa1808721. Epub
      2018 Aug 26.