PMID- 30114458
OWN - NLM
STAT- MEDLINE
DCOM- 20181214
LR  - 20181214
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 144
DP  - 2018 Oct
TI  - Greater inflammation and adiposity are associated with lower bone mineral density
      in youth with type 1 diabetes.
PG  - 10-16
LID - S0168-8227(18)30510-2 [pii]
LID - 10.1016/j.diabres.2018.07.032 [doi]
AB  - AIMS: The objectives of this study were to investigate relationships of
      inflammation and adiposity with bone mineral density (BMD) in youth with type 1
      diabetes followed prospectively for 18months. METHODS: Participants were youth
      with type 1 diabetes (n=136, 8-16.9years) enrolled in an 18-month behavioral
      nutrition intervention trial. BMD of the total body, subtotal, lumbar spine,
      pelvis leg, arm and rib, percent body fat and percent trunk fat (by dual energy
      x-ray absorptiometry) and C-reactive protein (CRP), a marker of inflammation,
      were assessed at baseline, 12 and 18months. Linear mixed-effects models estimated
      associations of time-varying BMD with time-varying CRP, and with percent body and
      trunk fat. RESULTS: CRP was inversely associated with BMD of the total body,
      pelvis and leg (n=136). Percent body fat was inversely associated with BMD of the
      total body and pelvis; whereas percent trunk fat was related only to total body
      BMD. CONCLUSIONS: Greater inflammation and adiposity were related to lower BMD in
      youth with type 1 diabetes. Investigating the impact of inflammation and
      adiposity on bone turnover markers could provide insights on mechanisms that
      contribute to this relationship.
CI  - Published by Elsevier B.V.
FAU - Sanjeevi, Namrata
AU  - Sanjeevi N
AD  - Social and Behavioral Sciences Branch, Eunice Kennedy Shriver National Institute 
      of Child Health and Human Development, United States. Electronic address:
      namrata.sanjeevi@nih.gov.
FAU - Lipsky, Leah M
AU  - Lipsky LM
AD  - Social and Behavioral Sciences Branch, Eunice Kennedy Shriver National Institute 
      of Child Health and Human Development, United States.
FAU - Nansel, Tonja R
AU  - Nansel TR
AD  - Social and Behavioral Sciences Branch, Eunice Kennedy Shriver National Institute 
      of Child Health and Human Development, United States.
LA  - eng
GR  - HHSN267200703434C/HD/NICHD NIH HHS/United States
GR  - Z99 HD999999/NULL/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180813
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Biomarkers)
SB  - IM
MH  - *Adiposity
MH  - Adolescent
MH  - Biomarkers/metabolism
MH  - *Bone Density
MH  - Bone Diseases, Metabolic/diagnosis/*etiology/metabolism
MH  - Child
MH  - Diabetes Mellitus, Type 1/*physiopathology
MH  - Female
MH  - Humans
MH  - Inflammation/*complications
MH  - Male
MH  - Prospective Studies
PMC - PMC6202251
MID - NIHMS1503609
OTO - NOTNLM
OT  - Adiposity
OT  - Bone mineral density
OT  - Inflammation
OT  - Type 1 diabetes
EDAT- 2018/08/17 06:00
MHDA- 2018/12/15 06:00
CRDT- 2018/08/17 06:00
PMCR- 2019/10/01 00:00
PHST- 2018/03/28 00:00 [received]
PHST- 2018/06/22 00:00 [revised]
PHST- 2018/07/30 00:00 [accepted]
PHST- 2019/10/01 00:00 [pmc-release]
PHST- 2018/08/17 06:00 [pubmed]
PHST- 2018/12/15 06:00 [medline]
PHST- 2018/08/17 06:00 [entrez]
AID - S0168-8227(18)30510-2 [pii]
AID - 10.1016/j.diabres.2018.07.032 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 Oct;144:10-16. doi: 10.1016/j.diabres.2018.07.032. 
      Epub 2018 Aug 13.