PMID- 30093139
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 272
DP  - 2018 Dec 1
TI  - Does second-generation cryoballoon ablation using the current single short freeze
      strategy produce pulmonary vein stenosis?
PG  - 175-178
LID - S0167-5273(18)34073-7 [pii]
LID - 10.1016/j.ijcard.2018.08.004 [doi]
AB  - BACKGROUND: Few data are available regarding pulmonary vein (PV) stenosis after
      second-generation cryoballoon PV isolation (CB2-PVI). Currently, a single short
      freeze strategy is standard for CB2-PVI owing to enhanced cooling effects. This
      study aimed to evaluate the incidence of PV stenosis after CB2-PVI with the
      current standard strategy. METHODS: Two hundred seventy-six atrial fibrillation
      patients underwent CB2-PVI using one 28-mm balloon and single 3-minute freeze
      strategy. If balloon temperatures reached -60 degrees C or phrenic nerve injury
      was suspected, freezing was terminated. Enhanced cardiac computed tomography (CT)
      was obtained before and >3months after the procedure. RESULTS: Overall, 1067 of
      1101 (96.9%) PVs were isolated with cryoballoons, while the remaining 34 PVs
      required touch-up ablation. The total application number/patient was 5.1+/-1.4,
      and total application time 216+/-104, 205+/-77, 186+/-68, and 246+/-142s for the 
      left superior (LSPV), left inferior (LIPV), right superior (RSPV), and right
      inferior PVs, respectively. Follow-up CT obtained a median of 5.0 [3.3-7.0]
      months post-procedure revealed no PVs with moderate or severe stenosis.
      Asymptomatic mild stenosis was documented in 16 total (1.4%) PVs (5 LSPVs, 5
      LIPVs, and 6 RSPVs), but not in right inferior, left common, right middle, or PVs
      requiring touch-up ablation. Mild stenosis did not progress during the follow-up.
      Among the potential factors associated with PV stenosis, longer application times
      were the sole significant factor associated with mild RSPV stenosis. CONCLUSIONS:
      In CB2-PVI with the current single short freeze strategy, the risk of PV stenosis
      is extremely low, and routine follow-up imaging for evaluation seems not to be
      necessary.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Miyazaki, Shinsuke
AU  - Miyazaki S
AD  - Department of Cardiovascular medicine, Fukui University, Fukui, Japan. Electronic
      address: mshinsuke@k3.dion.ne.jp.
FAU - Kajiyama, Takatsugu
AU  - Kajiyama T
AD  - Department of Cardiovascular medicine, Fukui University, Fukui, Japan.
FAU - Hada, Masahiro
AU  - Hada M
AD  - Department of Cardiovascular medicine, Fukui University, Fukui, Japan.
FAU - Nakamura, Hiroaki
AU  - Nakamura H
AD  - Department of Cardiovascular medicine, Fukui University, Fukui, Japan.
FAU - Hachiya, Hitoshi
AU  - Hachiya H
AD  - Department of Cardiovascular medicine, Fukui University, Fukui, Japan.
FAU - Tada, Hiroshi
AU  - Tada H
AD  - Department of Cardiovascular medicine, Fukui University, Fukui, Japan.
FAU - Hirao, Kenzo
AU  - Hirao K
AD  - Department of Cardiovascular medicine, Fukui University, Fukui, Japan.
FAU - Iesaka, Yoshito
AU  - Iesaka Y
AD  - Department of Cardiovascular medicine, Fukui University, Fukui, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180804
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*diagnostic imaging/physiopathology/*surgery
MH  - Catheter Ablation/adverse effects/*trends
MH  - Cryosurgery/adverse effects/*trends
MH  - Electrocardiography/trends
MH  - Female
MH  - Follow-Up Studies
MH  - *Freezing/adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Veins/diagnostic imaging
MH  - Stenosis, Pulmonary Vein/*diagnostic imaging/etiology
OTO - NOTNLM
OT  - Atrial fibrillation
OT  - Catheter ablation
OT  - Complication
OT  - Cryoballoon
OT  - Pulmonary vein stenosis
EDAT- 2018/08/11 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/08/11 06:00
PHST- 2018/06/24 00:00 [received]
PHST- 2018/07/17 00:00 [revised]
PHST- 2018/08/02 00:00 [accepted]
PHST- 2018/08/11 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/08/11 06:00 [entrez]
AID - S0167-5273(18)34073-7 [pii]
AID - 10.1016/j.ijcard.2018.08.004 [doi]
PST - ppublish
SO  - Int J Cardiol. 2018 Dec 1;272:175-178. doi: 10.1016/j.ijcard.2018.08.004. Epub
      2018 Aug 4.