PMID- 30089160
OWN - NLM
STAT- MEDLINE
DCOM- 20190208
LR  - 20190215
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 8
DP  - 2018
TI  - Erectile dysfunction in obstructive sleep apnea patients: A randomized trial on
      the effects of Continuous Positive Airway Pressure (CPAP).
PG  - e0201930
LID - 10.1371/journal.pone.0201930 [doi]
AB  - OBJECTIVES: Obstructive sleep apnea (OSA) is among the least studied risk factors
      for erectile dysfunction (ED). We aimed to determine ED prevalence in
      newly-diagnosed OSA patients, describe their main characteristics and assess
      continuous positive airway pressure (CPAP) effects on ED. METHODS:
      Cross-sectional study assessing ED prevalence in OSA patients and open-label,
      parallel, prospective randomized controlled trial evaluating 3-month CPAP
      treatment effects on sexual function, satisfaction, and psychological, hormonal
      and biochemical profiles. Male patients newly diagnosed with moderate/severe OSA 
      (apnea-hypopnea index >20 events.h-1), aged 18-70 years, attending the sleep unit
      of a Spanish hospital during 2013-2016 were considered. A total of 150 patients
      were recruited (75 randomized ED patients). ED was defined as scores <25 on
      International Index Erectile Function 15 test. Wilcoxon's matched-pairs
      signed-ranks and rank-sum tests were used. RESULTS: ED prevalence was 51%.
      Patients with ED were older (p<0.001), had greater waist-to-hip ratios (p<0.001),
      were more frequently undergoing pharmacological treatment (p<0.001) and had
      higher glucose levels (p = 0.024) than non-ED patients. Although significant
      increases in erectile function (mean(SD) change: +4.6(7.9); p = 0.002), overall
      satisfaction (+1(2.2); p = 0.035), and sexual satisfaction (+2.1(4.3); p = 0.003)
      were found after CPAP treatment, only differences in sexual satisfaction (p =
      0.027) and erectile function (p = 0.060) were found between study arms. CPAP
      treatment did not impact psychological, hormonal or biochemical profiles.
      CONCLUSIONS: This study confirmed the relationship between OSA and ED, suggesting
      the potential usefulness of ED screening in OSA patients, but could not determine
      conclusively whether CPAP is an effective stand-alone ED treatment, regardless of
      positive results on sexual satisfaction. TRIAL REGISTRATION: ClinicalTrials.gov
      NCT03086122.
FAU - Pascual, Merce
AU  - Pascual M
AD  - Urology Department, Hospital Universitari Santa Maria, Lleida, Spain.
AD  - Group of Translational Research in Respiratory Medicine, Hospital Universitari
      Arnau de Vilanova and Santa Maria, IRBLLEIDA, Lleida, Spain.
FAU - de Batlle, Jordi
AU  - de Batlle J
AUID- ORCID: 0000-0003-3500-6608
AD  - Group of Translational Research in Respiratory Medicine, Hospital Universitari
      Arnau de Vilanova and Santa Maria, IRBLLEIDA, Lleida, Spain.
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES),
      Madrid, Spain.
FAU - Barbe, Ferran
AU  - Barbe F
AD  - Group of Translational Research in Respiratory Medicine, Hospital Universitari
      Arnau de Vilanova and Santa Maria, IRBLLEIDA, Lleida, Spain.
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES),
      Madrid, Spain.
FAU - Castro-Grattoni, Anabel L
AU  - Castro-Grattoni AL
AD  - Group of Translational Research in Respiratory Medicine, Hospital Universitari
      Arnau de Vilanova and Santa Maria, IRBLLEIDA, Lleida, Spain.
FAU - Auguet, Josep M
AU  - Auguet JM
AD  - Urology Department, Hospital Universitari Santa Maria, Lleida, Spain.
FAU - Pascual, Lydia
AU  - Pascual L
AD  - Group of Translational Research in Respiratory Medicine, Hospital Universitari
      Arnau de Vilanova and Santa Maria, IRBLLEIDA, Lleida, Spain.
FAU - Vila, Manel
AU  - Vila M
AD  - Group of Translational Research in Respiratory Medicine, Hospital Universitari
      Arnau de Vilanova and Santa Maria, IRBLLEIDA, Lleida, Spain.
FAU - Cortijo, Anunciacion
AU  - Cortijo A
AD  - Group of Translational Research in Respiratory Medicine, Hospital Universitari
      Arnau de Vilanova and Santa Maria, IRBLLEIDA, Lleida, Spain.
FAU - Sanchez-de-la-Torre, Manuel
AU  - Sanchez-de-la-Torre M
AUID- ORCID: 0000-0002-5695-348X
AD  - Group of Translational Research in Respiratory Medicine, Hospital Universitari
      Arnau de Vilanova and Santa Maria, IRBLLEIDA, Lleida, Spain.
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES),
      Madrid, Spain.
LA  - eng
SI  - ClinicalTrials.gov/NCT03086122
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180808
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Continuous Positive Airway Pressure
MH  - Cross-Sectional Studies
MH  - Erectile Dysfunction/*epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Assessment
MH  - Risk Factors
MH  - Self Concept
MH  - Sleep Apnea, Obstructive/*complications/*epidemiology/therapy
MH  - Spain/epidemiology
MH  - Young Adult
PMC - PMC6082539
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/08/09 06:00
MHDA- 2019/02/09 06:00
CRDT- 2018/08/09 06:00
PHST- 2018/04/27 00:00 [received]
PHST- 2018/07/20 00:00 [accepted]
PHST- 2018/08/09 06:00 [entrez]
PHST- 2018/08/09 06:00 [pubmed]
PHST- 2019/02/09 06:00 [medline]
AID - 10.1371/journal.pone.0201930 [doi]
AID - PONE-D-18-12365 [pii]
PST - epublish
SO  - PLoS One. 2018 Aug 8;13(8):e0201930. doi: 10.1371/journal.pone.0201930.
      eCollection 2018.