PMID- 30086143
OWN - NLM
STAT- MEDLINE
DCOM- 20190123
LR  - 20190123
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 8
DP  - 2018
TI  - Impact of early hyperoxia on 28-day in-hospital mortality in patients with
      myocardial injury.
PG  - e0201286
LID - 10.1371/journal.pone.0201286 [doi]
AB  - INTRODUCTION: Despite relevant evidence that supplemental oxygen therapy can be
      harmful to patients with myocardial injury, the association between hyperoxia and
      the clinical outcome of such patients has not been evaluated. We assessed whether
      early hyperoxia negatively affects outcomes in hospitalized patients with
      myocardial injury. METHODS: This was a retrospective study conducted at a
      tertiary referral teaching hospital. Between January 2010 and December 2016,
      2,376 consecutive emergency department patients with myocardial injury, defined
      as a peak troponin-I level >/= 0.2 ng/mL, within the first 24 hours of
      presentation were included. The metrics used to define hyperoxia were the maximum
      average partial pressure of oxygen (PaO2MAX), average partial pressure of oxygen 
      (PaO2AVG), and area under the curve during the first 24 hours (AUC24). The
      association between early hyperoxia within 24 hours after presentation and
      clinical outcomes was evaluated using multiple imputation and logistic regression
      analysis. The primary outcome was 28-day in-hospital mortality. The secondary
      outcomes were new-onset cardiovascular, coagulation, hepatic, renal, and
      respiratory dysfunctions (sequential organ failure sub-score >/= 2). RESULTS:
      Compared with normoxic patients, the adjusted odds ratios (ORs) for PaO2MAX,
      PaO2AVG, and AUC24 were 1.55 (95% confidence interval (CI) 1.05-2.27; p = 0.026),
      2.13 (95% CI 1.45-3.12; p = 0.001), and 1.73 (95% CI 1.15-2.61; p = 0.008),
      respectively, in patients with mild hyperoxia and 6.01 (95% CI 3.98-9.07; p <
      0.001), 8.92 (95% CI 3.33-23.88; p < 0.001), and 7.32 (95% CI 2.72-19.70; p =
      0.001), respectively, in patients with severe hyperoxia. The incidence of
      coagulation and hepatic dysfunction (sequential organ failure sub-score >/= 2)
      was significantly higher in the mild and severe hyperoxia group. CONCLUSIONS:
      Hyperoxia during the first 24 hours of presentation is associated with an
      increased 28-day in-hospital mortality rate and risks of coagulation and hepatic 
      dysfunction in patients with myocardial injury.
FAU - Kim, Tae Yun
AU  - Kim TY
AD  - Department of Emergency Medicine, Gyeongsang National University School of
      Medicine and and Gyeongsang National University Hospital, Jinju, Republic of
      Korea.
FAU - Kim, Dong Hoon
AU  - Kim DH
AUID- ORCID: 0000-0001-6040-7206
AD  - Department of Emergency Medicine, Gyeongsang National University School of
      Medicine and and Gyeongsang National University Hospital, Jinju, Republic of
      Korea.
AD  - Gyeongsang Institute of Health Sciences, Gyeongsang National University School of
      Medicine, Jinju, Republic of Korea.
FAU - Kim, Seong Chun
AU  - Kim SC
AD  - Department of Emergency Medicine, Gyeongsang National University School of
      Medicine and Gyeongsang National University Changwon Hospital, Changwon, Republic
      of Korea.
FAU - Kang, Changwoo
AU  - Kang C
AUID- ORCID: 0000-0002-2045-3213
AD  - Department of Emergency Medicine, Gyeongsang National University School of
      Medicine and and Gyeongsang National University Hospital, Jinju, Republic of
      Korea.
AD  - Gyeongsang Institute of Health Sciences, Gyeongsang National University School of
      Medicine, Jinju, Republic of Korea.
FAU - Lee, Soo Hoon
AU  - Lee SH
AUID- ORCID: 0000-0002-2512-5905
AD  - Department of Emergency Medicine, Gyeongsang National University School of
      Medicine and and Gyeongsang National University Hospital, Jinju, Republic of
      Korea.
FAU - Jeong, Jin Hee
AU  - Jeong JH
AD  - Department of Emergency Medicine, Gyeongsang National University School of
      Medicine and and Gyeongsang National University Hospital, Jinju, Republic of
      Korea.
AD  - Gyeongsang Institute of Health Sciences, Gyeongsang National University School of
      Medicine, Jinju, Republic of Korea.
FAU - Lee, Sang Bong
AU  - Lee SB
AD  - Department of Emergency Medicine, Gyeongsang National University School of
      Medicine and and Gyeongsang National University Hospital, Jinju, Republic of
      Korea.
FAU - Park, Yong Joo
AU  - Park YJ
AD  - Department of Emergency Medicine, Gyeongsang National University School of
      Medicine and Gyeongsang National University Changwon Hospital, Changwon, Republic
      of Korea.
FAU - Lim, Daesung
AU  - Lim D
AD  - Department of Emergency Medicine, Gyeongsang National University School of
      Medicine and Gyeongsang National University Changwon Hospital, Changwon, Republic
      of Korea.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180807
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Disease-Free Survival
MH  - Female
MH  - *Hospital Mortality
MH  - Humans
MH  - *Hyperoxia/chemically induced/metabolism/mortality
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Infarction/drug therapy/metabolism/mortality
MH  - Oxygen/administration & dosage/*adverse effects
MH  - Risk Factors
MH  - Survival Rate
MH  - Time Factors
PMC - PMC6080775
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/08/08 06:00
MHDA- 2019/01/24 06:00
CRDT- 2018/08/08 06:00
PHST- 2018/03/01 00:00 [received]
PHST- 2018/07/12 00:00 [accepted]
PHST- 2018/08/08 06:00 [entrez]
PHST- 2018/08/08 06:00 [pubmed]
PHST- 2019/01/24 06:00 [medline]
AID - 10.1371/journal.pone.0201286 [doi]
AID - PONE-D-18-05768 [pii]
PST - epublish
SO  - PLoS One. 2018 Aug 7;13(8):e0201286. doi: 10.1371/journal.pone.0201286.
      eCollection 2018.