PMID- 30084493
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Linking)
VI  - 41
IP  - 10
DP  - 2018 Oct
TI  - Left ventricular thrombosis in acute anterior myocardial infarction: Evaluation
      of hospital mortality, thromboembolism, and bleeding.
PG  - 1289-1296
LID - 10.1002/clc.23039 [doi]
AB  - BACKGROUND: Left ventricular thrombosis (LVT) is a well-known complication of
      acute myocardial infarction, most commonly seen in anterior wall ST-segment
      elevation myocardial infarction (STEMI). It is associated with systemic
      thromboembolism. HYPOTHESIS: Our aim was to evaluate the impact of LVT on
      in-hospital mortality, thromboembolism, and bleeding in patients with anterior
      STEMI. METHODS: Data was collected from the Nationwide Inpatient Sample where
      patients with a primary diagnosis of "Anterior STEMI" [ICD9-CM code 410.1] were
      included. Comparisons were made between patients with LVT [ICD9-CM code 429.79]
      vs those without using propensity score matching (PSM). RESULTS: From 2002 to
      2014, there were 157 891 cases of anterior STEMI. Among these, 649 (0.4%) had
      LVT. Post-PSM, there was no difference in in-hospital mortality between the
      groups with LVT and without (7.3% vs 8.6%). Thromboembolic event rate was higher 
      with LVT compared to those without LVT (7.3% vs 2.1%). There was no difference in
      bleeding events between patients with LVT and those without (2.9% vs 3.2%). The
      baseline average length of stay in the group with LVT was longer than the group
      without LVT (7.9 +/- 6.7 days vs 5.1 +/- 6.0 days). The average
      hospitalization-related costs were also significantly higher among patients with 
      LVT compared to those without (95 598 USD vs 66 641 USD per stay) at baseline.
      CONCLUSION: Among patients hospitalized with anterior STEMI, presence of LVT is
      associated with increased thromboembolic events, average length of hospital stay 
      and average cost of hospitalization. However, it is not associated with increased
      in-hospital mortality or bleeding events.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Ram, Pradhum
AU  - Ram P
AUID- ORCID: http://orcid.org/0000-0003-3406-9260
AD  - Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
FAU - Shah, Mahek
AU  - Shah M
AUID- ORCID: http://orcid.org/0000-0002-5065-3355
AD  - Division of Cardiology, Lehigh Valley Hospital Network, Allentown, Pennsylvania.
FAU - Sirinvaravong, Natee
AU  - Sirinvaravong N
AD  - Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
FAU - Lo, Kevin Bryan
AU  - Lo KB
AUID- ORCID: http://orcid.org/0000-0001-7088-6677
AD  - Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
FAU - Patil, Shantanu
AU  - Patil S
AD  - Department of Medicine, University of Pittsburg Medical Center, Pittsburg,
      Pennsylvania.
FAU - Patel, Brijesh
AU  - Patel B
AUID- ORCID: http://orcid.org/0000-0001-8973-8228
AD  - Division of Cardiology, Lehigh Valley Hospital Network, Allentown, Pennsylvania.
FAU - Tripathi, Byomesh
AU  - Tripathi B
AD  - Department of Medicine, Mount Sinai St Luke's-Roosevelt Hospital, New York, New
      York.
FAU - Garg, Lohit
AU  - Garg L
AD  - Division of Cardiology, Lehigh Valley Hospital Network, Allentown, Pennsylvania.
FAU - Figueredo, Vincent
AU  - Figueredo V
AUID- ORCID: http://orcid.org/0000-0003-0301-5649
AD  - Department of Cardiology, Albert Einstein Medical Center, Philadelphia,
      Pennsylvania.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20181016
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Fibrinolytic Agents)
SB  - IM
CIN - Clin Cardiol. 2018 Oct;41(10):1297. PMID: 30225918
CIN - Clin Cardiol. 2018 Oct;41(10):1298-1299. PMID: 30225891
MH  - Anterior Wall Myocardial Infarction/*complications/epidemiology/therapy
MH  - Echocardiography
MH  - Female
MH  - Fibrinolytic Agents/adverse effects/therapeutic use
MH  - Follow-Up Studies
MH  - Heart Diseases/diagnosis/epidemiology/etiology
MH  - Heart Ventricles
MH  - Hemorrhage/chemically induced/*epidemiology
MH  - Hospital Mortality/trends
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention
MH  - Propensity Score
MH  - Retrospective Studies
MH  - ST Elevation Myocardial Infarction/*complications/epidemiology/therapy
MH  - Survival Rate/trends
MH  - Thromboembolism/epidemiology/*etiology/prevention & control
MH  - Thrombolytic Therapy/*adverse effects
MH  - Thrombosis/diagnosis/epidemiology/*etiology
MH  - Time Factors
MH  - United States/epidemiology
OTO - NOTNLM
OT  - anterior STEMI
OT  - cardiac thrombosis
OT  - left ventricular thrombus
OT  - thromboembolism
EDAT- 2018/08/08 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/08/08 06:00
PHST- 2018/06/16 00:00 [received]
PHST- 2018/07/30 00:00 [revised]
PHST- 2018/08/02 00:00 [accepted]
PHST- 2018/08/08 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/08/08 06:00 [entrez]
AID - 10.1002/clc.23039 [doi]
PST - ppublish
SO  - Clin Cardiol. 2018 Oct;41(10):1289-1296. doi: 10.1002/clc.23039. Epub 2018 Oct
      16.