PMID- 30074472
DCOM- 20180911
LR  - 20180911
IS  - 1473-5644 (Electronic)
IS  - 0022-2615 (Linking)
VI  - 67
IP  - 9
DP  - 2018 Sep
TI  - Beyond proteostasis: Roles of type I chaperonins in bacterial pathogenesis.
PG  - 1203-1211
LID - 10.1099/jmm.0.000811 [doi]
AB  - Nearly all bacterial species express two or more chaperonin genes. Recent data
      indicate that type I chaperonins may be key players in bacterial infections. This
      is partly due to the well-known contribution of chaperonins in cellular
      proteostasis, the latter being compromised during bacterial host infection. In
      addition to their protein-folding activity, it has been revealed that certain
      chaperonins also exhibit moonlighting functions that can contribute in different 
      ways to bacterial pathogenicity. Examples range from inducing adhesion molecules 
      in Chlamydophila pneumoniae to supporting intracellular survival in Mycobacterium
      tuberculosis and Leishmania donovani, to inducing cytokines in Helicobacter
      pylori to promoting antimicrobial resistance in Escherichia coli, amongst others.
      This article provides a thorough reviews of our current understanding of the
      different mechanisms involving type I chaperonins during bacteria-host
      interactions, and suggests new areas to be explored and the potential of finding 
      new targets for fighting bacterial infections.
FAU - Ghazaei, Ciamak
AU  - Ghazaei C
AD  - 1Department of Microbiology, University of Mohaghegh Ardabili, Ardabil, Iran.
FAU - Line El Helou, Marie
AU  - Line El Helou M
AD  - 2School of Pharmacy, Lebanese American University, Byblos, Lebanon.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180803
PL  - England
TA  - J Med Microbiol
JT  - Journal of medical microbiology
JID - 0224131
RN  - 0 (Bacterial Proteins)
RN  - EC 3.6.1.- (Group I Chaperonins)
SB  - IM
MH  - Animals
MH  - Bacteria/genetics/*metabolism
MH  - Bacterial Infections/microbiology
MH  - Bacterial Proteins/genetics/*metabolism
MH  - Group I Chaperonins/genetics/*metabolism
MH  - Humans
MH  - *Proteostasis
OT  - GroE
OT  - bacteria
OT  - chaperonin
OT  - moonlighting
OT  - pathogenicity
EDAT- 2018/08/04 06:00
MHDA- 2018/09/12 06:00
CRDT- 2018/08/04 06:00
PHST- 2018/08/04 06:00 [pubmed]
PHST- 2018/09/12 06:00 [medline]
PHST- 2018/08/04 06:00 [entrez]
AID - 10.1099/jmm.0.000811 [doi]
PST - ppublish
SO  - J Med Microbiol. 2018 Sep;67(9):1203-1211. doi: 10.1099/jmm.0.000811. Epub 2018
      Aug 3.