PMID- 30059000
OWN - NLM
STAT- MEDLINE
DCOM- 20180911
LR  - 20180911
IS  - 1473-5644 (Electronic)
IS  - 0022-2615 (Linking)
VI  - 67
IP  - 9
DP  - 2018 Sep
TI  - Characterization of the clonal subpopulation Fiocruz L1-130 of Leptospira
      interrogans in rats and dogs from Brazil.
PG  - 1361-1367
LID - 10.1099/jmm.0.000806 [doi]
AB  - PURPOSE: Leptospira interrogans serogroup Icterohaemorrhagiae strains have been
      described as causing disease in both humans and animals and as being present
      worldwide. Icterohaemorrhagiae and Copenhageni serovars are known to cause severe
      disease in their hosts, and zoonotic outbreaks have been described. The genetic
      similarity among the strains of these serovars is known. However, it has not yet 
      been demonstrated whether major clonal subpopulation in humans, strain Fiocruz
      L1-130-like, can circulate among other hosts. METHODOLOGY: We performed genetic
      characterization of Brazilian serogroup Icterohaemorrhagiae strains of dog and
      rat origin by secY sequencing, variable-number tandem-repeat, multilocus sequence
      type and multi-spacer typing analysis. RESULTS: The strains were found to be
      identical among themselves and to strain Fiocruz L1-130. We suggest that the
      major strain of L. interrogans serogroup Icterohaemorrhagiae, Fiocruz L1-130, is 
      widely distributed in Brazil in different hosts with substantial zoonotic
      potential. CONCLUSION: Understanding the circulation of strain Fiocruz L1-130 is 
      important for the implementation of appropriate control measures. Its circulation
      highlights the need to treat leptospirosis caused by L. interrogans serogroup
      Icterohaemorrhagiae as a zoonosis that acts in the human-animal-environment
      interface, as per the One Health approach.
FAU - Jaeger, Lauren Hubert
AU  - Jaeger LH
AD  - 1Laboratory of Veterinary Bacteriology, Department of Microbiology and
      Parasitology, Universidade Federal Fluminense, Niteroi, RJ, Brazil.
AD  - 2Laboratory of Epidemiology and Molecular Systematics, Oswaldo Cruz Institute,
      Fiocruz, Rio de Janeiro 21040-900, Brazil.
FAU - Pestana, Cristiane Pinheiro
AU  - Pestana CP
AD  - 3Bio-Manguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
FAU - Carvalho-Costa, Filipe Anibal
AU  - Carvalho-Costa FA
AD  - 2Laboratory of Epidemiology and Molecular Systematics, Oswaldo Cruz Institute,
      Fiocruz, Rio de Janeiro 21040-900, Brazil.
FAU - Medeiros, Marco Alberto
AU  - Medeiros MA
AD  - 3Bio-Manguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
FAU - Lilenbaum, Walter
AU  - Lilenbaum W
AD  - 1Laboratory of Veterinary Bacteriology, Department of Microbiology and
      Parasitology, Universidade Federal Fluminense, Niteroi, RJ, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180730
PL  - England
TA  - J Med Microbiol
JT  - Journal of medical microbiology
JID - 0224131
SB  - IM
MH  - Animals
MH  - Brazil
MH  - Dog Diseases/*microbiology
MH  - Dogs
MH  - Leptospira interrogans/classification/genetics/*isolation & purification
MH  - Leptospirosis/microbiology/*veterinary
MH  - Minisatellite Repeats
MH  - Multilocus Sequence Typing
MH  - Phylogeny
MH  - Rats
MH  - Rodent Diseases/*microbiology
OTO - NOTNLM
OT  - MLST
OT  - MST
OT  - VNTR
OT  - genotyping
OT  - serogroup Icterohaemorrhagiae
EDAT- 2018/07/31 06:00
MHDA- 2018/09/12 06:00
CRDT- 2018/07/31 06:00
PHST- 2018/07/31 06:00 [pubmed]
PHST- 2018/09/12 06:00 [medline]
PHST- 2018/07/31 06:00 [entrez]
AID - 10.1099/jmm.0.000806 [doi]
PST - ppublish
SO  - J Med Microbiol. 2018 Sep;67(9):1361-1367. doi: 10.1099/jmm.0.000806. Epub 2018
      Jul 30.