PMID- 30054863
OWN - NLM
STAT- MEDLINE
DCOM- 20181221
LR  - 20181221
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 50
IP  - 9
DP  - 2018 Sep
TI  - Is the plasma endocan level a reliable predictor for the severity of erectile
      dysfunction?
PG  - 1577-1582
LID - 10.1007/s11255-018-1946-2 [doi]
AB  - PURPOSE: The aim of our study was to assess the correlation between serum endocan
      level and erectile dysfunction (ED). METHODS: A total of 92 patients were
      reviewed in this study after institutional review board approval. The patients'
      characteristics were recorded, including age, body mass index, blood pressure,
      smoking history, serum creatinine, glucose, lipid profile, total testosterone,
      and Beck Depression Inventory scores. ED was evaluated with the Sexual Health
      Inventory for Men (SHIM) questionnaire and classified as severe, moderate, or
      mild. Scores of > 18 indicate normal erectile function and were recruited for the
      control group. RESULTS: Sixty-three patients with a median age of 56 years in the
      ED group and 29 patients with a median age of 55 years in the control group were 
      compared. ED was classified as severe in 20, moderate in 25, and mild in 18
      patients. A significant difference was determined between the severe ED group and
      the control group for serum endocan levels (p < 0.001). A significant negative
      correlation between the SHIM score and endocan levels (rho - 0.65; p < 0.01), age
      and SHIM score (rho - 0.32; p = 0.04), BMI and SHIM score (rho - 0.25; p = 0.03),
      and BMI and total testosterone (rho - 0.16; p = 0.04) was determined upon
      Spearman's correlation analysis. A positive correlation was also determined
      between total testosterone and SHIM score (rho 0.50; p = 0.04). Patients' age (p 
      = 0.037) and serum endocan level (p = 0.029) were determined as significant in
      the multivariate analysis. CONCLUSION: This study demonstrated the presence of an
      association between plasma endocan levels and ED. Endocan may be used as a new
      diagnostic marker for the severity of ED.
FAU - Onuk, Ozkan
AU  - Onuk O
AD  - Department of Urology, Yeni Yuzyil University, Istanbul, Turkey.
FAU - Arslan, Burak
AU  - Arslan B
AD  - Department of Urology, Istanbul Taksim Gaziosmanpasa Training and Research
      Hospital, Karayollari Str. No:621 Gaziosmanpasa, Istanbul, Turkey.
      drbarslan@yahoo.com.
FAU - Gezmis, Tugrul Cem
AU  - Gezmis TC
AD  - Department of Urology, Istanbul Taksim Gaziosmanpasa Training and Research
      Hospital, Karayollari Str. No:621 Gaziosmanpasa, Istanbul, Turkey.
FAU - Cetin, Bugra
AU  - Cetin B
AD  - Department of Urology, Istanbul Taksim Gaziosmanpasa Training and Research
      Hospital, Karayollari Str. No:621 Gaziosmanpasa, Istanbul, Turkey.
FAU - Gov, Taha
AU  - Gov T
AD  - Department of Urology, Istanbul Taksim Gaziosmanpasa Training and Research
      Hospital, Karayollari Str. No:621 Gaziosmanpasa, Istanbul, Turkey.
FAU - Yazici, Gokhan
AU  - Yazici G
AD  - Department of Urology, Istanbul Taksim Gaziosmanpasa Training and Research
      Hospital, Karayollari Str. No:621 Gaziosmanpasa, Istanbul, Turkey.
FAU - Gurkan, Okan
AU  - Gurkan O
AD  - Department of Radiology, Istanbul Taksim Gaziosmanpasa Training and Research
      Hospital, Istanbul, Turkey.
FAU - Ozdemir, Enver
AU  - Ozdemir E
AD  - Department of Urology, Istanbul Taksim Gaziosmanpasa Training and Research
      Hospital, Karayollari Str. No:621 Gaziosmanpasa, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20180727
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (Biomarkers)
RN  - 0 (ESM1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proteoglycans)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Erectile Dysfunction/*blood/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*blood
MH  - Predictive Value of Tests
MH  - Proteoglycans/*blood
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Testosterone/blood
OTO - NOTNLM
OT  - Biomarker
OT  - Endothelial damage
OT  - Erectile dysfunction
EDAT- 2018/07/29 06:00
MHDA- 2018/12/24 06:00
CRDT- 2018/07/29 06:00
PHST- 2018/05/30 00:00 [received]
PHST- 2018/07/25 00:00 [accepted]
PHST- 2018/07/29 06:00 [pubmed]
PHST- 2018/12/24 06:00 [medline]
PHST- 2018/07/29 06:00 [entrez]
AID - 10.1007/s11255-018-1946-2 [doi]
AID - 10.1007/s11255-018-1946-2 [pii]
PST - ppublish
SO  - Int Urol Nephrol. 2018 Sep;50(9):1577-1582. doi: 10.1007/s11255-018-1946-2. Epub 
      2018 Jul 27.