PMID- 30025650
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 269
DP  - 2018 Oct 15
TI  - Coupling interval variability: A new diagnostic method for distinguishing left
      from right ventricular outflow tract origin in idiopathic outflow tract premature
      ventricular contractions patients with precordial R/S transition at lead V3.
PG  - 126-132
LID - S0167-5273(18)33703-3 [pii]
LID - 10.1016/j.ijcard.2018.07.045 [doi]
AB  - BACKGROUND: To distinguish left ventricular outflow tract (LVOT) from right
      ventricular outflow tract (RVOT) origin in idiopathic outflow tract premature
      ventricular contractions (IOT-PVCs) patients with precordial R/S transition at
      lead V3 is still a challenge. We sought to develop a new electrocardiography
      (ECG) method for distinguishing LVOT from RVOT origin in IOT-PVCs patients with
      precordial R/S transition at lead V3. METHODS: We analyzed the surface 12-lead
      ECG characteristics and the difference of coupling interval variability (CIV) of 
      PVCs between distinct origin sites in a retrospective cohort of IOT-PVCs patients
      with precordial R/S transition at lead V3 who underwent successful radiofrequency
      catheter ablation (RFCA) to develop a new diagnostic method, then validated it in
      a prospective cohort. RESULTS: A total of 196 consecutive patients (41+/-15years,
      36.7% male) underwent RFCA of IOT-PVCs between January 2014 and August 2016.
      Among them, 68 patients (34.7%, 23 male) with precordial R/S transition at lead
      V3 constituted the retrospective cohort. Based on the areas under the receiver
      operating characteristic curves (AUCs), a CIV>100ms with the largest value of AUC
      was selected to develop a new diagnostic method with a specificity of 93.9% and
      an accuracy of 92.6%. It correctly identified the origin site of 38 from 41
      patients in the prospective cohort, demonstrating a 96.8% specificity and 92.7%
      accuracy. CONCLUSIONS: We presented a new simple method, a CIV>100ms which could 
      reliably distinguish LVOT from RVOT origin in IOT-PVCs patients with precordial
      R/S transition at lead V3.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Qin, Fen
AU  - Qin F
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South
      University, Changsha City, Hunan Province 410011, China.
FAU - Zhao, Yuwei
AU  - Zhao Y
AD  - Department of Cardiology, Shanghai Chest Hospital of Shanghai Jiao Tong
      University, Shanghai City 200030, China.
FAU - Bai, Fan
AU  - Bai F
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South
      University, Changsha City, Hunan Province 410011, China.
FAU - Ma, Yingxu
AU  - Ma Y
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South
      University, Changsha City, Hunan Province 410011, China.
FAU - Sun, Chao
AU  - Sun C
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South
      University, Changsha City, Hunan Province 410011, China.
FAU - Liu, Na
AU  - Liu N
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South
      University, Changsha City, Hunan Province 410011, China.
FAU - Li, Biao
AU  - Li B
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South
      University, Changsha City, Hunan Province 410011, China.
FAU - Li, Yixi
AU  - Li Y
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South
      University, Changsha City, Hunan Province 410011, China.
FAU - Liu, Chaoshuo
AU  - Liu C
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South
      University, Changsha City, Hunan Province 410011, China.
FAU - Liu, Qiming
AU  - Liu Q
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South
      University, Changsha City, Hunan Province 410011, China. Electronic address:
      qimingliu@csu.edu.cn.
FAU - Zhou, Shenghua
AU  - Zhou S
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South
      University, Changsha City, Hunan Province 410011, China.
LA  - eng
PT  - Journal Article
DEP - 20180709
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Electrocardiography/instrumentation/*methods
MH  - Electrodes
MH  - Female
MH  - Heart Ventricles/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Ventricular Outflow Obstruction/diagnostic imaging/*physiopathology
MH  - Ventricular Premature Complexes/diagnostic imaging/*physiopathology
OTO - NOTNLM
OT  - Coupling interval variability
OT  - Electrocardiogram
OT  - Left ventricular outflow tract
OT  - Precordial R/S transition
OT  - Premature ventricular contractions
EDAT- 2018/07/22 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/07/21 06:00
PHST- 2018/06/09 00:00 [received]
PHST- 2018/07/04 00:00 [revised]
PHST- 2018/07/06 00:00 [accepted]
PHST- 2018/07/22 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/07/21 06:00 [entrez]
AID - S0167-5273(18)33703-3 [pii]
AID - 10.1016/j.ijcard.2018.07.045 [doi]
PST - ppublish
SO  - Int J Cardiol. 2018 Oct 15;269:126-132. doi: 10.1016/j.ijcard.2018.07.045. Epub
      2018 Jul 9.