PMID- 30020197
OWN - NLM
STAT- MEDLINE
DCOM- 20190422
LR  - 20190422
IS  - 1473-5636 (Electronic)
IS  - 0960-8931 (Linking)
VI  - 28
IP  - 5
DP  - 2018 Oct
TI  - Acral melanoma: a retrospective cohort from the Brazilian National Cancer
      Institute (INCA).
PG  - 458-464
LID - 10.1097/CMR.0000000000000476 [doi]
AB  - Acral melanoma (AM) is a rare subtype of melanoma arising on the palms, soles and
      subungual areas. In the Brazilian and Latin American populations, the
      sociodemographic and clinical-pathologic features of AM are unclear. AM tends to 
      be more advanced at presentation because of delayed diagnoses, with poor
      survival. This study reports on a retrospective AM cohort from the Brazilian
      National Cancer Institute. We reviewed a database of 529 patients presenting with
      AM from 1997 to 2014 and analysed the sociodemographic and clinical-pathologic
      features of AM associated with overall survival and relapse-free survival. All
      patients were Brazilian, ranging in age from 19 to 101 years (mean 65.4; median
      67.0). Two hundred and ninety-four (55.8%) patients were women. The Breslow
      primary lesion thicknesses ranged from 0.0 to 65.0 mm (mean 8.3 mm; median 5.0
      mm). Of these patients, 43.3% had the acral lentiginous histologic subtype.
      Plantar was the most frequently involved site (68.5%), and ulcers and mitosis
      were present in 79.0 and 86.4% of these cases, respectively. Multivariate
      analysis results found that Breslow thickness of 1.03 (95% confidence interval:
      1.01-1.05; P=0.01) and ulceration of 2.70 (95% confidence interval: 1.00-7.06;
      P=0.05) were poor prognostic indicators of overall survival. AM tumours were
      thick on diagnostic tests and were associated with poorer survival outcomes.
      Unfavourable prognosis likely derives from the delayed diagnosis compared with
      other melanoma subtypes.
FAU - Nunes, Luiz F
AU  - Nunes LF
AD  - Brazilian National Cancer Institute-INCA-Cancer Hospital II.
FAU - Quintella Mendes, Gelcio L
AU  - Quintella Mendes GL
AD  - Brazilian National Cancer Institute-INCA-Cancer Hospital II.
FAU - Koifman, Rosalina J
AU  - Koifman RJ
AD  - Oswaldo Cruz Foundation/National School of Public Health (ENSP/FIOCRUZ), Rio de
      Janeiro, Brazil.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Melanoma Res
JT  - Melanoma research
JID - 9109623
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brazil
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Melanoma/*diagnosis/pathology
MH  - Middle Aged
MH  - National Cancer Institute (U.S.)
MH  - Prognosis
MH  - Retrospective Studies
MH  - Skin Neoplasms/*diagnosis/pathology
MH  - United States
MH  - Young Adult
EDAT- 2018/07/19 06:00
MHDA- 2019/04/23 06:00
CRDT- 2018/07/19 06:00
PHST- 2018/07/19 06:00 [pubmed]
PHST- 2019/04/23 06:00 [medline]
PHST- 2018/07/19 06:00 [entrez]
AID - 10.1097/CMR.0000000000000476 [doi]
PST - ppublish
SO  - Melanoma Res. 2018 Oct;28(5):458-464. doi: 10.1097/CMR.0000000000000476.