PMID- 30010120
OWN - NLM
STAT- In-Process
LR  - 20190507
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 64
IP  - 4
DP  - 2018
TI  - Dual-Task Gait and Alzheimer's Disease Genetic Risk in Cognitively Normal Adults:
      A Pilot Study.
PG  - 1137-1148
LID - 10.3233/JAD-180016 [doi]
AB  - BACKGROUND: Dual-task paradigms, in which an individual performs tasks separately
      and then concurrently, often demonstrate that people with neurodegenerative
      disorders experience more dual-task interference, defined as worse performance in
      the dual-task condition compared to the single-task condition. OBJECTIVE: To
      examine how gait-cognition dual-task performance differs between cognitively
      normal older adults with and without an APOE varepsilon4 allele. METHODS:
      Twenty-nine individuals ages 60 to 72 with normal cognition completed a dual-task
      protocol in which walking and cognitive tasks (executive function, memory) were
      performed separately and concurrently. Fourteen participants carried APOE
      varepsilon4 alleles (varepsilon3/varepsilon4 or varepsilon2/varepsilon4); fifteen
      had APOE genotypes (varepsilon2/varepsilon2, varepsilon2/varepsilon3, or
      varepsilon3/varepsilon3) associated with lower risk of Alzheimer's disease (AD). 
      RESULTS: The two risk groups did not differ by age, sex, race, education, or gait
      or cognitive measures under single-task conditions. Compared to low risk
      participants, APOE varepsilon4 carriers tended to exhibit greater dual-task
      interference. Both the memory and executive function tasks resulted in dual-task 
      interference on gait, but effect sizes for a group difference were larger when
      the cognitive task was executive function. In the dual-task protocol that
      combined walking and the executive function task, effect sizes for group
      difference in gait interference were larger (0.62- 0.70) than for cognitive
      interference (0.45- 0.47). DISCUSSION: Dual-task paradigms may reveal subtle
      changes in brain function in asymptomatic individuals at heightened risk of AD.
FAU - Whitson, Heather E
AU  - Whitson HE
AD  - Department of Medicine (Geriatrics), Duke University School of Medicine, Durham, 
      NC, USA.
AD  - Center for the Study of Aging and Human Development, Duke University School of
      Medicine, Durham, NC, USA.
AD  - Durham VA Geriatrics Research Education and Clinical Center (GRECC), Durham, NC, 
      USA.
FAU - Potter, Guy G
AU  - Potter GG
AD  - Center for the Study of Aging and Human Development, Duke University School of
      Medicine, Durham, NC, USA.
AD  - Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University
      School of Medicine, Durham, NC, USA.
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of
      Medicine, Durham, NC, USA.
FAU - Feld, Jody A
AU  - Feld JA
AD  - Department of Orthopedic Surgery, Doctor of Physical Therapy Division, Duke
      University School of Medicine, Durham, NC, USA.
FAU - Plassman, Brenda L
AU  - Plassman BL
AD  - Center for the Study of Aging and Human Development, Duke University School of
      Medicine, Durham, NC, USA.
AD  - Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University
      School of Medicine, Durham, NC, USA.
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of
      Medicine, Durham, NC, USA.
FAU - Reynolds, Kelly
AU  - Reynolds K
AD  - Center for the Study of Aging and Human Development, Duke University School of
      Medicine, Durham, NC, USA.
FAU - Sloane, Richard
AU  - Sloane R
AD  - Center for the Study of Aging and Human Development, Duke University School of
      Medicine, Durham, NC, USA.
FAU - Welsh-Bohmer, Kathleen A
AU  - Welsh-Bohmer KA
AD  - Center for the Study of Aging and Human Development, Duke University School of
      Medicine, Durham, NC, USA.
AD  - Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University
      School of Medicine, Durham, NC, USA.
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of
      Medicine, Durham, NC, USA.
LA  - eng
GR  - P30 AG028716/AG/NIA NIH HHS/United States
GR  - R01 AG043438/AG/NIA NIH HHS/United States
GR  - U13 AG054139/AG/NIA NIH HHS/United States
GR  - UH2 AG056925/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, N.I.H., Extramural
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
PMC - PMC6500574
MID - NIHMS1026115
OTO - NOTNLM
OT  - *Aging brain
OT  - *cognitive performance
OT  - *cognitive reserve
OT  - *dementia
OT  - *diagnosis
OT  - *early detection
OT  - *motor interference
OT  - *phenotype
OT  - *risk
OT  - *stress test
EDAT- 2018/07/17 06:00
MHDA- 2018/07/17 06:00
CRDT- 2018/07/17 06:00
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2018/07/17 06:00 [entrez]
AID - JAD180016 [pii]
AID - 10.3233/JAD-180016 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2018;64(4):1137-1148. doi: 10.3233/JAD-180016.