PMID- 29998921
OWN - NLM
STAT- In-Data-Review
LR  - 20180925
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 82
IP  - 10
DP  - 2018 Sep 25
TI  - Early-Phase Vascular Healing of Bioabsorbable vs. Durable Polymer-Coated
      Everolimus-Eluting Stents in Patients With ST-Elevation Myocardial Infarction-
      2-Week and 4-Month Analyses With Optical Coherence Tomography.
PG  - 2594-2601
LID - 10.1253/circj.CJ-18-0230 [doi]
AB  - BACKGROUND: Despite the revolution of coronary stents, there remain concerns
      about the risk of stent thrombosis, especially in patients with ST-elevation
      myocardial infarction (STEMI). The present study compared early vascular healing 
      as a contributing factor to reducing stent thrombosis between Xience
      everolimus-eluting stents (X-EES) and Synergy everolimus-eluting stents (S-EES)
      in patients with STEMI. Methods and Results: The present study included 47
      patients with STEMI requiring primary percutaneous coronary intervention with
      X-EES (n=25) or S-EES (n=22). Optical coherence tomography (OCT) assessments of
      the stented lesions were performed 2 weeks and 4 months after stent implantation.
      Neointimal strut coverage, malapposition and the frequency of thrombus formation 
      were evaluated. In the 2-week OCT analysis, the proportion of covered struts in
      S-EES (42.4+/-15.4%) was significantly higher than in X-EES (26.3+/-10.1%,
      P<0.001). In the 4-month OCT analysis, the proportion of covered struts in S-EES 
      (72.2+/-17.9%) was still significantly higher than in X-EES (62.0+/-14.9%,
      P=0.04). CONCLUSIONS: Compared with X-EES, S-EES showed a higher proportion of
      covered struts in the early phase after stent implantation for STEMI patients.
FAU - Shimoda, Masahiro
AU  - Shimoda M
AD  - Department of Cardiology, Aichi Medical University.
FAU - Ando, Hirohiko
AU  - Ando H
AD  - Department of Cardiology, Aichi Medical University.
FAU - Naito, Kazuhiro
AU  - Naito K
AD  - Department of Cardiology, Aichi Medical University.
FAU - Suzuki, Akihiro
AU  - Suzuki A
AD  - Department of Cardiology, Aichi Medical University.
FAU - Sakurai, Shinichiro
AU  - Sakurai S
AD  - Department of Cardiology, Aichi Medical University.
FAU - Nakano, Yusuke
AU  - Nakano Y
AD  - Department of Cardiology, Aichi Medical University.
FAU - Kurita, Akiyoshi
AU  - Kurita A
AD  - Department of Cardiology, Aichi Medical University.
FAU - Waseda, Katsuhisa
AU  - Waseda K
AD  - Department of Cardiology, Aichi Medical University.
FAU - Takashima, Hiroaki
AU  - Takashima H
AD  - Department of Cardiology, Aichi Medical University.
FAU - Murotani, Kenta
AU  - Murotani K
AD  - Division of Biostatistics, Clinical Research Center, Aichi Medical University.
FAU - Uetani, Tadayuki
AU  - Uetani T
AD  - Uetani Clinic.
FAU - Amano, Tetsuya
AU  - Amano T
AD  - Department of Cardiology, Aichi Medical University.
LA  - eng
PT  - Journal Article
DEP - 20180711
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
OTO - NOTNLM
OT  - Neointimal coverage
OT  - Stent thrombosis
OT  - Vascular healing
EDAT- 2018/07/13 06:00
MHDA- 2018/07/13 06:00
CRDT- 2018/07/13 06:00
PHST- 2018/07/13 06:00 [pubmed]
PHST- 2018/07/13 06:00 [medline]
PHST- 2018/07/13 06:00 [entrez]
AID - 10.1253/circj.CJ-18-0230 [doi]
PST - ppublish
SO  - Circ J. 2018 Sep 25;82(10):2594-2601. doi: 10.1253/circj.CJ-18-0230. Epub 2018
      Jul 11.