PMID- 29921691
OWN - NLM
STAT- In-Data-Review
LR  - 20190419
IS  - 1538-7445 (Electronic)
IS  - 0008-5472 (Linking)
VI  - 78
IP  - 16
DP  - 2018 Aug 15
TI  - Influence of Smoking, Body Mass Index, and Other Factors on the Preventive Effect
      of Nonsteroidal Anti-Inflammatory Drugs on Colorectal Cancer Risk.
PG  - 4790-4799
LID - 10.1158/0008-5472.CAN-18-0326 [doi]
AB  - Nonsteroidal anti-inflammatory drugs' (NSAID) use has consistently been
      associated with lower risk of colorectal cancer; however, studies showed
      inconsistent results on which cohort of individuals may benefit most. We
      performed multivariable logistic regression analysis to systematically test for
      the interaction between regular use of NSAIDs and other lifestyle and dietary
      factors on colorectal cancer risk among 11,894 cases and 15,999 controls.
      Fixed-effects meta-analyses were used for stratified analyses across studies for 
      each risk factor and to summarize the estimates from interactions. Regular use of
      any NSAID, aspirin, or nonaspirin NSAIDs was significantly associated with a
      lower risk of colorectal cancer within almost all subgroups. However, smoking
      status and BMI were found to modify the NSAID-colorectal cancer association.
      Aspirin use was associated with a 29% lower colorectal cancer risk among
      never-smokers [odds ratios (OR) = 0.71; 95% confidence intervals (CI):
      0.64-0.79], compared with 19% and 17% lower colorectal cancer risk among smokers 
      of pack-years below median (OR, 0.81; 95% CI, 0.71-0.92) and above median (OR,
      0.83; 95% CI, 0.74-0.94), respectively (P interaction = 0.048). The association
      between any NSAID use and colorectal cancer risk was also attenuated with
      increasing BMI (P interaction = 0.075). Collectively, these results suggest that 
      obese individuals and heavy smokers are unlikely to benefit as much as other
      groups from the prophylactic effect of aspirin against colorectal
      cancer.Significance: Obesity and heavy smoking attenuate the benefit of aspirin
      use for colorectal cancer prevention. Cancer Res; 78(16); 4790-9. (c)2018 AACR.
CI  - (c)2018 American Association for Cancer Research.
FAU - Wang, Xiaoliang
AU  - Wang X
AD  - Department of Epidemiology, University of Washington, Seattle, Washington.
      xwang23@fhcrc.org.
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, Washington.
FAU - Chan, Andrew T
AU  - Chan AT
AD  - Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and 
      Harvard Medical School, Boston, Massachusetts.
AD  - Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard
      Medical School, Boston, Massachusetts.
FAU - Slattery, Martha L
AU  - Slattery ML
AUID- ORCID: https://orcid.org/0000-0002-1655-6543
AD  - Department of Internal Medicine, University of Utah Health Sciences Center, Salt 
      Lake City, Utah.
FAU - Chang-Claude, Jenny
AU  - Chang-Claude J
AUID- ORCID: https://orcid.org/0000-0001-8919-1971
AD  - Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg,
      Germany.
FAU - Potter, John D
AU  - Potter JD
AUID- ORCID: https://orcid.org/0000-0001-5439-1500
AD  - Department of Epidemiology, University of Washington, Seattle, Washington.
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, Washington.
AD  - Centre for Public Health Research, Massey University, Wellington, New Zealand.
FAU - Gallinger, Steven
AU  - Gallinger S
AD  - Department of Pathology and Laboratory Medicine, Samuel Lunenfeld Research
      Institute, Toronto, Ontario, Canada.
AD  - Division of General Surgery, Toronto General Hospital, Toronto, Ontario, Canada.
FAU - Caan, Bette
AU  - Caan B
AD  - Division of Research, Kaiser Permanente Medical Care Program, Oakland.
FAU - Lampe, Johanna W
AU  - Lampe JW
AD  - Department of Epidemiology, University of Washington, Seattle, Washington.
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, Washington.
FAU - Newcomb, Polly A
AU  - Newcomb PA
AD  - Department of Epidemiology, University of Washington, Seattle, Washington.
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, Washington.
FAU - Zubair, Niha
AU  - Zubair N
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, Washington.
FAU - Hsu, Li
AU  - Hsu L
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, Washington.
FAU - Schoen, Robert E
AU  - Schoen RE
AUID- ORCID: https://orcid.org/0000-0001-7153-2766
AD  - Department of Medicine and Epidemiology, University of Pittsburgh Medical Center,
      Pittsburgh, Pennsylvania.
FAU - Hoffmeister, Michael
AU  - Hoffmeister M
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research
      Center (DKFZ), Heidelberg, Germany.
FAU - Brenner, Hermann
AU  - Brenner H
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research
      Center (DKFZ), Heidelberg, Germany.
AD  - Division of Preventive Oncology, German Cancer Research Center (DKFZ) and
      National Center for Tumor Diseases (NCT), Heidelberg, Germany.
AD  - German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ),
      Heidelberg, Germany.
FAU - Le Marchand, Loic
AU  - Le Marchand L
AD  - Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
FAU - Peters, Ulrike
AU  - Peters U
AD  - Department of Epidemiology, University of Washington, Seattle, Washington.
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, Washington.
FAU - White, Emily
AU  - White E
AD  - Department of Epidemiology, University of Washington, Seattle, Washington.
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, Washington.
LA  - eng
GR  - R01 CA059045/CA/NCI NIH HHS/United States
GR  - HHSN268201100001I/HL/NHLBI NIH HHS/United States
GR  - R01 CA076366/CA/NCI NIH HHS/United States
GR  - R35 CA197735/CA/NCI NIH HHS/United States
GR  - P01 CA087969/CA/NCI NIH HHS/United States
GR  - HHSN268201100004I/HL/NHLBI NIH HHS/United States
GR  - K05 CA154337/CA/NCI NIH HHS/United States
GR  - P01 CA055075/CA/NCI NIH HHS/United States
GR  - R01 CA151993/CA/NCI NIH HHS/United States
GR  - HHSN268201100046C/HL/NHLBI NIH HHS/United States
GR  - R01 CA048998/CA/NCI NIH HHS/United States
GR  - R25 CA094880/CA/NCI NIH HHS/United States
GR  - U01 CA137088/CA/NCI NIH HHS/United States
GR  - HHSN268201100003C/WH/WHI NIH HHS/United States
GR  - R01 CA137178/CA/NCI NIH HHS/United States
GR  - HHSN271201100004C/AG/NIA NIH HHS/United States
GR  - R01 CA063464/CA/NCI NIH HHS/United States
GR  - P01 CA033619/CA/NCI NIH HHS/United States
GR  - UM1 CA186107/CA/NCI NIH HHS/United States
GR  - HHSN268201100002C/WH/WHI NIH HHS/United States
GR  - R01 CA042182/CA/NCI NIH HHS/United States
GR  - R01 CA060987/CA/NCI NIH HHS/United States
GR  - UM1 CA167552/CA/NCI NIH HHS/United States
GR  - S10 OD020069/OD/NIH HHS/United States
GR  - HHSN268201100002I/HL/NHLBI NIH HHS/United States
GR  - U01 CA074783/CA/NCI NIH HHS/United States
GR  - P50 CA127003/CA/NCI NIH HHS/United States
GR  - K07 CA190673/CA/NCI NIH HHS/United States
GR  - P30 CA071789/CA/NCI NIH HHS/United States
GR  - R37 CA054281/CA/NCI NIH HHS/United States
GR  - HHSN268201100001C/WH/WHI NIH HHS/United States
GR  - HHSN268201100004C/WH/WHI NIH HHS/United States
PT  - Journal Article
DEP - 20180619
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
PMC - PMC6095723
MID - NIHMS977459
EDAT- 2018/06/21 06:00
MHDA- 2018/06/21 06:00
CRDT- 2018/06/21 06:00
PMCR- 2019/08/15 00:00
PHST- 2018/02/01 00:00 [received]
PHST- 2018/06/01 00:00 [revised]
PHST- 2018/06/15 00:00 [accepted]
PHST- 2019/08/15 00:00 [pmc-release]
PHST- 2018/06/21 06:00 [pubmed]
PHST- 2018/06/21 06:00 [medline]
PHST- 2018/06/21 06:00 [entrez]
AID - 0008-5472.CAN-18-0326 [pii]
AID - 10.1158/0008-5472.CAN-18-0326 [doi]
PST - ppublish
SO  - Cancer Res. 2018 Aug 15;78(16):4790-4799. doi: 10.1158/0008-5472.CAN-18-0326.
      Epub 2018 Jun 19.