PMID- 29884408
OWN - NLM
STAT- In-Data-Review
LR  - 20180911
IS  - 1879-0593 (Electronic)
IS  - 1368-8375 (Linking)
VI  - 81
DP  - 2018 Jun
TI  - The role of protein methyltransferases as potential novel therapeutic targets in 
      squamous cell carcinoma of the head and neck.
PG  - 100-108
LID - S1368-8375(18)30156-8 [pii]
LID - 10.1016/j.oraloncology.2018.04.014 [doi]
AB  - Squamous cell carcinoma of the head and neck is a lethal disease with suboptimal 
      survival outcomes and standard therapies with significant comorbidities. Whole
      exome sequencing data recently revealed an abundance of genetic and expression
      alterations in a family of enzymes known as protein methyltransferases in a
      variety of cancer types, including squamous cell carcinoma of the head and neck. 
      These enzymes are mostly known for their chromatin-modifying functions through
      methylation of various histone substrates, though evidence supports their
      function also through methylation of non-histone substrates. This review
      summarizes the current knowledge on the function of protein methyltransferases in
      squamous cell carcinoma of the head and neck and highlights their promising
      potential as the next generation of therapeutic targets in this disease.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Saloura, Vassiliki
AU  - Saloura V
AD  - Thoracic and Gastrointestinal Malignancies Group, Center for Cancer Research,
      National Cancer Institute, United States. Electronic address:
      vassiliki.saloura@nih.gov.
FAU - Vougiouklakis, Theodore
AU  - Vougiouklakis T
AD  - Department of Medicine, University of Chicago, United States.
FAU - Sievers, Cem
AU  - Sievers C
AD  - Thoracic and Gastrointestinal Malignancies Group, Center for Cancer Research,
      National Cancer Institute, United States.
FAU - Burkitt, Kyunghee
AU  - Burkitt K
AD  - Thoracic and Gastrointestinal Malignancies Group, Center for Cancer Research,
      National Cancer Institute, United States.
FAU - Nakamura, Yusuke
AU  - Nakamura Y
AD  - Department of Medicine, University of Chicago, United States; Department of
      Surgery, University of Chicago, United States.
FAU - Hager, Gordon
AU  - Hager G
AD  - Thoracic and Gastrointestinal Malignancies Group, Center for Cancer Research,
      National Cancer Institute, United States.
FAU - van Waes, Carter
AU  - van Waes C
AD  - Head and Neck Surgery Branch, National Institutes of Deafness and Communication
      Disorders, United States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180503
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
EIN - Oral Oncol. 2018 Nov;86:318. PMID: 30201513
OTO - NOTNLM
OT  - EHMT2
OT  - EZH2
OT  - NSD1
OT  - NSD2
OT  - NSD3
OT  - PRMT1
OT  - PRMT5
OT  - Protein methylation
OT  - Protein methyltransferase
OT  - Squamous cell carcinoma of the head and neck
EDAT- 2018/06/10 06:00
MHDA- 2018/06/10 06:00
CRDT- 2018/06/10 06:00
PHST- 2018/02/20 00:00 [received]
PHST- 2018/04/10 00:00 [revised]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/06/10 06:00 [entrez]
PHST- 2018/06/10 06:00 [pubmed]
PHST- 2018/06/10 06:00 [medline]
AID - S1368-8375(18)30156-8 [pii]
AID - 10.1016/j.oraloncology.2018.04.014 [doi]
PST - ppublish
SO  - Oral Oncol. 2018 Jun;81:100-108. doi: 10.1016/j.oraloncology.2018.04.014. Epub
      2018 May 3.