PMID- 29866865
OWN - NLM
STAT- In-Data-Review
LR  - 20190127
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 62
IP  - 8
DP  - 2018 Aug
TI  - Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other
      Gram-Positive Bacteria.
LID - e00453-18 [pii]
LID - 10.1128/AAC.00453-18 [doi]
AB  - The activities of four oxadiazoles were investigated with 210
      methicillin-resistant Staphylococcus aureus (MRSA) strains. MIC50 and MIC90
      values of 1 to 2 and 4 mug/ml, respectively, were observed. We also evaluated the
      activity of oxadiazole ND-421 against other staphylococci and enterococci and in 
      the presence of oxacillin for selected MRSA strains. The MIC for ND-421 is
      lowered severalfold in combination with oxacillin, as they synergize. The MIC90
      of ND-421 against vancomycin-resistant enterococci is </=1 mug/ml.
CI  - Copyright (c) 2018 American Society for Microbiology.
FAU - Ceballos, Sara
AU  - Ceballos S
AD  - Area of Biochemistry and Molecular Biology, University of La Rioja, Logrono,
      Spain.
FAU - Kim, Choon
AU  - Kim C
AD  - Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame,
      Indiana, USA.
FAU - Ding, Derong
AU  - Ding D
AD  - Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame,
      Indiana, USA.
FAU - Mobashery, Shahriar
AU  - Mobashery S
AD  - Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame,
      Indiana, USA.
FAU - Chang, Mayland
AU  - Chang M
AD  - Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame,
      Indiana, USA mchang@nd.edu carmen.torres@unirioja.es.
FAU - Torres, Carmen
AU  - Torres C
AD  - Area of Biochemistry and Molecular Biology, University of La Rioja, Logrono,
      Spain mchang@nd.edu carmen.torres@unirioja.es.
LA  - eng
GR  - R01 AI090818/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20180727
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
PMC - PMC6105842
OTO - NOTNLM
OT  - Enterococcus
OT  - MIC
OT  - MRSA
OT  - PBPs
OT  - Staphylococcus spp.
OT  - oxadiazole
EDAT- 2018/06/06 06:00
MHDA- 2018/06/06 06:00
CRDT- 2018/06/06 06:00
PHST- 2018/03/07 00:00 [received]
PHST- 2018/05/26 00:00 [accepted]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/06/06 06:00 [medline]
PHST- 2018/06/06 06:00 [entrez]
AID - AAC.00453-18 [pii]
AID - 10.1128/AAC.00453-18 [doi]
PST - epublish
SO  - Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: AAC.00453-18. doi:
      10.1128/AAC.00453-18. Print 2018 Aug.