PMID- 29859589
OWN - NLM
STAT- MEDLINE
DCOM- 20181017
LR  - 20181017
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 110
DP  - 2018 Jul
TI  - Radiological differences between HIV-positive and HIV-negative children with
      cholesteatoma.
PG  - 6-11
LID - S0165-5876(18)30176-9 [pii]
LID - 10.1016/j.ijporl.2018.04.011 [doi]
AB  - INTRODUCTION: HIV-positive children are possibly more prone to developing
      cholesteatoma. Chronic inflammation of the middle ear cleft may be more common in
      patients with HIV and this may predispose HIV-positive children to developing
      cholesteatoma. There are no studies that describe the radiological morphology of 
      the middle ear cleft in HIV-positive compared to HIV-negative children with
      cholesteatoma. OBJECTIVES: Compare the radiological differences of the middle ear
      cleft in HIV-positive and HIV-negative children with cholesteatoma. METHODS: A
      retrospective, cross-sectional, observational analytical review of patients with 
      cholesteatoma at our institute over a 6 year period. RESULTS: Forty patients were
      included in the study, 11 of whom had bilateral cholesteatoma and therefore 51
      ears were eligible for our evaluation. HIV-positive patients had smaller (p=0.02)
      mastoid air cell systems (MACS). Forty percent of HIV-positive patients had
      sclerotic mastoids, whereas the rate was 3% in HIV-negative ears (p<0.02).
      Eighty-two percent of the HIV-positive patients had bilateral cholesteatoma
      compared to 7% of the control group (p<0.02). There was no difference between the
      2 groups with regards to opacification of the middle ear cleft, bony erosion of
      middle ear structures, Eustachian tube obstruction or soft tissue occlusion of
      the post-nasal space. CONCLUSION: HIV-positive paediatric patients with
      cholesteatoma are more likely to have smaller, sclerotic mastoids compared to
      HIV-negative patients. They are significantly more likely to have bilateral
      cholesteatoma. This may have implications in terms of surveillance of
      HIV-positive children, as well as, an approach to management, recurrence and
      follow-up. HIV infection should be flagged as a risk factor for developing
      cholesteatoma.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - McGuire, J K
AU  - McGuire JK
AD  - Division of Otorhinolaryngology, Faculty of Health Sciences, University of Cape
      Town, South Africa. Electronic address: jkmcguire2@gmail.com.
FAU - Fagan, J J
AU  - Fagan JJ
AD  - Division of Otorhinolaryngology, Faculty of Health Sciences, University of Cape
      Town, South Africa.
FAU - Wojno, M
AU  - Wojno M
AD  - Division of Otorhinolaryngology, Faculty of Health Sciences, University of Cape
      Town, South Africa.
FAU - Manning, K
AU  - Manning K
AD  - Division of Otorhinolaryngology, Faculty of Health Sciences, University of Cape
      Town, South Africa.
FAU - Harris, T
AU  - Harris T
AD  - Division of Otorhinolaryngology, Faculty of Health Sciences, University of Cape
      Town, South Africa.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180414
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cholesteatoma, Middle Ear/*diagnostic imaging/virology
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/*complications/diagnostic imaging
MH  - Humans
MH  - Male
MH  - Mastoid/diagnostic imaging
MH  - Radiography
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Cholesteatoma
OT  - HIV
OT  - Imaging
OT  - Otology
OT  - Pediatric otology
EDAT- 2018/06/04 06:00
MHDA- 2018/10/18 06:00
CRDT- 2018/06/04 06:00
PHST- 2017/05/31 00:00 [received]
PHST- 2018/04/10 00:00 [revised]
PHST- 2018/04/11 00:00 [accepted]
PHST- 2018/06/04 06:00 [entrez]
PHST- 2018/06/04 06:00 [pubmed]
PHST- 2018/10/18 06:00 [medline]
AID - S0165-5876(18)30176-9 [pii]
AID - 10.1016/j.ijporl.2018.04.011 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2018 Jul;110:6-11. doi:
      10.1016/j.ijporl.2018.04.011. Epub 2018 Apr 14.