PMID- 29801739
OWN - NLM
STAT- MEDLINE
DCOM- 20190226
LR  - 20190226
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 34
IP  - 6
DP  - 2018 Jun
TI  - Long-term Follow-up of the Trial of Routine Angioplasty and Stenting After
      Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction
      (TRANSFER-AMI).
PG  - 736-743
LID - S0828-282X(18)30150-8 [pii]
LID - 10.1016/j.cjca.2018.02.005 [doi]
AB  - BACKGROUND: The Trial of Routine Angioplasty and Stenting after Fibrinolysis to
      Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI) demonstrated
      superiority of routine early coronary angiography (and percutaneous coronary
      intervention [PCI]) compared with standard therapy in fibrinolytic-treated
      patients with ST-segment elevation myocardial infarction (STEMI) at 30 days. The 
      aim of the current study was to evaluate the long-term (>7 year) effects of an
      early invasive strategy. METHODS: We linked the study cohort and administrative
      datasets to assess long-term follow-up status including repeat procedures,
      hospitalizations, and major adverse cardiovascular events (MACE). Kaplan-Meier
      and Cox regression analysis were used to evaluate the relationship between
      randomized treatment and long-term adverse outcomes. RESULTS: A total of 881
      patients had long-term follow-up and were included in our study. After a mean
      follow-up of 7.8 years, there were no significant differences in death,
      myocardial infarction (MI), unstable angina, stroke, transient ischemic attack
      (TIA), or heart failure admissions (hazard ratio [HR] 0.91; 95% confidence
      interval [CI] 0.73-1.13]; P = 0.41) between those randomized to an early invasive
      vs standard treatment strategy. Following the index hospitalization, there were
      no significant difference in the rates of coronary revascularization between the 
      early invasive and the standard therapy groups (81 [19.3%] vs 76 [17.9%]; P =
      0.61). CONCLUSIONS: Despite the short-term benefit and safety of an early
      invasive strategy in patients with STEMI receiving fibrinolysis, no statistically
      significant differences in MACE were observed over 7.8 years.
CI  - Copyright (c) 2018 Canadian Cardiovascular Society. Published by Elsevier Inc.
      All rights reserved.
FAU - Arbel, Yaron
AU  - Arbel Y
AD  - Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine,
      Tel Aviv University, Tel Aviv, Israel.
FAU - Ko, Dennis T
AU  - Ko DT
AD  - Schulich Heart Centre, Division of Cardiology, Sunnybrook Health Sciences Centre,
      University of Toronto, Ontario, Canada; Institute for Clinical Evaluative
      Sciences (ICES), Toronto, Ontario, Canada.
FAU - Yan, Andrew T
AU  - Yan AT
AD  - St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
FAU - Cantor, Warren J
AU  - Cantor WJ
AD  - Department of Cardiology, Southlake Regional Health Centre, University of
      Toronto, Ontario, Canada.
FAU - Bagai, Akshay
AU  - Bagai A
AD  - St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
FAU - Koh, Maria
AU  - Koh M
AD  - Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada.
FAU - Eberg, Maria
AU  - Eberg M
AD  - Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada.
FAU - Tan, Mary
AU  - Tan M
AD  - Canadian Heart Research Centre, Toronto, Ontario, Canada.
FAU - Fitchett, David
AU  - Fitchett D
AD  - St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
FAU - Borgundvaag, Bjug
AU  - Borgundvaag B
AD  - Schwartz/Reisman Emergency Medicine Institute at Mount Sinai Hospital, University
      of Toronto, Toronto, Ontario, Canada.
FAU - Ducas, John
AU  - Ducas J
AD  - St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada.
FAU - Heffernan, Michael
AU  - Heffernan M
AD  - Halton Healthcare Services, Oakville Hospital, Oakville, Ontario, Canada.
FAU - Morrison, Laurie J
AU  - Morrison LJ
AD  - Robert and Dorothy Pitts Chair of Acute Care and Emergency Medicine, Keenan
      Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital,
      University of Toronto, Toronto, Ontario, Canada.
FAU - Langer, Anatoly
AU  - Langer A
AD  - Canadian Heart Research Centre, Toronto, Ontario, Canada.
FAU - Dzavik, Vladimir
AU  - Dzavik V
AD  - University Health Network and Mount Sinai Hospital, University of Toronto,
      Toronto, Ontario, Canada.
FAU - Mehta, Shamir R
AU  - Mehta SR
AD  - Population Health Research Institute, Hamilton General Hospital, Hamilton,
      Ontario, Canada.
FAU - Goodman, Shaun G
AU  - Goodman SG
AD  - St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Canadian 
      Heart Research Centre, Toronto, Ontario, Canada. Electronic address:
      goodmans@smh.ca.
CN  - TRANSFER-AMI Trial Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT00164190
GR  - CIHR/Canada
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180210
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
RN  - 0 (Fibrinolytic Agents)
SB  - IM
CIN - Can J Cardiol. 2018 Jun;34(6):700-702. PMID: 29801734
MH  - Aged
MH  - *Angioplasty, Balloon, Coronary/adverse effects/methods
MH  - Coronary Angiography/*methods
MH  - Early Medical Intervention/methods/statistics & numerical data
MH  - Female
MH  - Fibrinolytic Agents/therapeutic use
MH  - Follow-Up Studies
MH  - Humans
MH  - *Long Term Adverse Effects/diagnosis/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Outcome and Process Assessment (Health Care)
MH  - *Percutaneous Coronary Intervention/adverse effects/methods
MH  - Retreatment/methods/statistics & numerical data
MH  - *ST Elevation Myocardial Infarction/epidemiology/therapy
MH  - Stents
MH  - Thrombolytic Therapy/*methods
EDAT- 2018/05/29 06:00
MHDA- 2019/02/27 06:00
CRDT- 2018/05/27 06:00
PHST- 2017/12/04 00:00 [received]
PHST- 2018/02/05 00:00 [revised]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/05/27 06:00 [entrez]
PHST- 2018/05/29 06:00 [pubmed]
PHST- 2019/02/27 06:00 [medline]
AID - S0828-282X(18)30150-8 [pii]
AID - 10.1016/j.cjca.2018.02.005 [doi]
PST - ppublish
SO  - Can J Cardiol. 2018 Jun;34(6):736-743. doi: 10.1016/j.cjca.2018.02.005. Epub 2018
      Feb 10.