PMID- 29782955
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 681
DP  - 2018 Aug 10
TI  - Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 
      of aged Alzheimer's disease mice.
PG  - 19-25
LID - S0304-3940(18)30362-8 [pii]
LID - 10.1016/j.neulet.2018.05.027 [doi]
AB  - Neuronal degeneration associated with Alzheimer's disease (AD), is linked to
      impaired calcium homeostasis and to changes in calcium-binding proteins (CBPs).
      The AD-related modification of neuronal CBPs remains controversial. Here we
      analysed the presence and expression of calretinin (CR) and parvalbumin (PV) in
      the hippocampal CA1 neurones of 18 months old 3xTg-AD mice compared to non-Tg
      animals. We found a layer specific decrease in number of interneurones expressing
      CR and PV (by 33.7% and 52%, respectively). Expression of PV decreased (by 13.8%)
      in PV-positive neurones, whereas expression of CR did not change in CR positive
      cells. The loss of specific subpopulations of Ca(2+)-binding proteins expressing 
      interneurones (CR and PV) together with the decrease of PV in the surviving cells
      may be linked to their vulnerability to AD pathology. Specific loss of inhibitory
      interneurones with age could contribute to overall increase in the network
      excitability associated with AD.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Zallo, Fatima
AU  - Zallo F
AD  - BioCruces Health Research Institute, 48903, Barakaldo, Spain; Department of
      Neuroscience, University of the Basque Country UPV/EHU, 48940, Leioa, Spain.
FAU - Gardenal, Emanuela
AU  - Gardenal E
AD  - Department of Neuroscience, University of the Basque Country UPV/EHU, 48940,
      Leioa, Spain; Human Histology and Embryology Unit, Medical School, University of 
      Verona, 37134, Verona, Italy.
FAU - Verkhratsky, Alexei
AU  - Verkhratsky A
AD  - Department of Neuroscience, University of the Basque Country UPV/EHU, 48940,
      Leioa, Spain; IKERBASQUE, Basque Foundation for Science, 48013-Bilbao, Medical
      School, Spain; Achucarro Basque Center for Neuroscience, 48940, Leioa, Spain;
      Faculty of Biology, Medicine and Health, The University of Manchester,
      Manchester, M13 9PL, United Kingdom; Center for Basic and Translational
      Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen,
      Copenhagen, 2200, Denmark.
FAU - Rodriguez, Jose Julio
AU  - Rodriguez JJ
AD  - BioCruces Health Research Institute, 48903, Barakaldo, Spain; Department of
      Neuroscience, University of the Basque Country UPV/EHU, 48940, Leioa, Spain;
      IKERBASQUE, Basque Foundation for Science, 48013-Bilbao, Medical School, Spain.
      Electronic address: j.rodriguez-arellano@ikerbasque.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180518
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Calb2 protein, mouse)
RN  - 0 (Calbindin 2)
RN  - 0 (Parvalbumins)
SB  - IM
MH  - Aging/genetics/*metabolism/pathology
MH  - Alzheimer Disease/genetics/*metabolism/pathology
MH  - Animals
MH  - CA1 Region, Hippocampal/*metabolism/pathology
MH  - Calbindin 2/genetics/*metabolism
MH  - Interneurons/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, 129 Strain
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Parvalbumins/genetics/*metabolism
OTO - NOTNLM
OT  - *Alzheimer's disease
OT  - *CA1
OT  - *Calretinin
OT  - *Hippocampus
OT  - *Parvalbumin
EDAT- 2018/05/22 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/05/22 06:00
PHST- 2017/12/28 00:00 [received]
PHST- 2018/04/30 00:00 [revised]
PHST- 2018/05/17 00:00 [accepted]
PHST- 2018/05/22 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/05/22 06:00 [entrez]
AID - S0304-3940(18)30362-8 [pii]
AID - 10.1016/j.neulet.2018.05.027 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 Aug 10;681:19-25. doi: 10.1016/j.neulet.2018.05.027. Epub
      2018 May 18.