PMID- 29771877
OWN - NLM
STAT- MEDLINE
DCOM- 20180518
LR  - 20181114
IS  - 1545-861X (Electronic)
IS  - 0149-2195 (Linking)
VI  - 67
IP  - 19
DP  - 2018 May 18
TI  - Cholera Epidemic - Lusaka, Zambia, October 2017-May 2018.
PG  - 556-559
LID - 10.15585/mmwr.mm6719a5 [doi]
AB  - On October 6, 2017, an outbreak of cholera was declared in Zambia after
      laboratory confirmation of Vibrio cholerae O1, biotype El Tor, serotype Ogawa,
      from stool specimens from two patients with acute watery diarrhea. The two
      patients had gone to a clinic in Lusaka, the capital city, on October 4. Cholera 
      cases increased rapidly, from several hundred cases in early December 2017 to
      approximately 2,000 by early January 2018 (Figure). In collaboration with
      partners, the Zambia Ministry of Health (MoH) launched a multifaceted public
      health response that included increased chlorination of the Lusaka municipal
      water supply, provision of emergency water supplies, water quality monitoring and
      testing, enhanced surveillance, epidemiologic investigations, a cholera
      vaccination campaign, aggressive case management and health care worker training,
      and laboratory testing of clinical samples. In late December 2017, a number of
      water-related preventive actions were initiated, including increasing chlorine
      levels throughout the city's water distribution system and placing emergency
      tanks of chlorinated water in the most affected neighborhoods; cholera cases
      declined sharply in January 2018. During January 10-February 14, 2018,
      approximately 2 million doses of oral cholera vaccine were administered to Lusaka
      residents aged >/=1 year. However, in mid-March, heavy flooding and widespread
      water shortages occurred, leading to a resurgence of cholera. As of May 12, 2018,
      the outbreak had affected seven of the 10 provinces in Zambia, with 5,905
      suspected cases and a case fatality rate (CFR) of 1.9%. Among the suspected
      cases, 5,414 (91.7%), including 98 deaths (CFR = 1.8%), occurred in Lusaka
      residents.
FAU - Sinyange, Nyambe
AU  - Sinyange N
FAU - Brunkard, Joan M
AU  - Brunkard JM
FAU - Kapata, Nathan
AU  - Kapata N
FAU - Mazaba, Mazyanga Lucy
AU  - Mazaba ML
FAU - Musonda, Kunda G
AU  - Musonda KG
FAU - Hamoonga, Raymond
AU  - Hamoonga R
FAU - Kapina, Muzala
AU  - Kapina M
FAU - Kapaya, Fred
AU  - Kapaya F
FAU - Mutale, Lwito
AU  - Mutale L
FAU - Kateule, Ernest
AU  - Kateule E
FAU - Nanzaluka, Francis
AU  - Nanzaluka F
FAU - Zulu, James
AU  - Zulu J
FAU - Musyani, Chileshe Lukwesa
AU  - Musyani CL
FAU - Winstead, Alison V
AU  - Winstead AV
FAU - Davis, William W
AU  - Davis WW
FAU - N'cho, Hammad S
AU  - N'cho HS
FAU - Mulambya, Nelia L
AU  - Mulambya NL
FAU - Sakubita, Patrick
AU  - Sakubita P
FAU - Chewe, Orbie
AU  - Chewe O
FAU - Nyimbili, Sulani
AU  - Nyimbili S
FAU - Onwuekwe, Ezinne V C
AU  - Onwuekwe EVC
FAU - Adrien, Nedghie
AU  - Adrien N
FAU - Blackstock, Anna J
AU  - Blackstock AJ
FAU - Brown, Travis W
AU  - Brown TW
FAU - Derado, Gordana
AU  - Derado G
FAU - Garrett, Nancy
AU  - Garrett N
FAU - Kim, Sunkyung
AU  - Kim S
FAU - Hubbard, Sydney
AU  - Hubbard S
FAU - Kahler, Amy M
AU  - Kahler AM
FAU - Malambo, Warren
AU  - Malambo W
FAU - Mintz, Eric
AU  - Mintz E
FAU - Murphy, Jennifer
AU  - Murphy J
FAU - Narra, Rupa
AU  - Narra R
FAU - Rao, Gouthami G
AU  - Rao GG
FAU - Riggs, Margaret A
AU  - Riggs MA
FAU - Weber, Nicole
AU  - Weber N
FAU - Yard, Ellen
AU  - Yard E
FAU - Zyambo, Khozya D
AU  - Zyambo KD
FAU - Bakyaita, Nathan
AU  - Bakyaita N
FAU - Monze, Namani
AU  - Monze N
FAU - Malama, Kennedy
AU  - Malama K
FAU - Mulwanda, Jabbin
AU  - Mulwanda J
FAU - Mukonka, Victor M
AU  - Mukonka VM
LA  - eng
PT  - Journal Article
DEP - 20180518
PL  - United States
TA  - MMWR Morb Mortal Wkly Rep
JT  - MMWR. Morbidity and mortality weekly report
JID - 7802429
RN  - 0 (Cholera Vaccines)
SB  - IM
MH  - Cholera/*epidemiology/prevention & control
MH  - Cholera Vaccines/administration & dosage
MH  - *Epidemics/prevention & control
MH  - Feces/microbiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Public Health Practice
MH  - Vibrio cholerae/isolation & purification
MH  - Zambia/epidemiology
PMC - PMC6048949
COIS- No conflicts of interest were reported.
EDAT- 2018/05/18 06:00
MHDA- 2018/05/19 06:00
CRDT- 2018/05/18 06:00
PHST- 2018/05/18 06:00 [entrez]
PHST- 2018/05/18 06:00 [pubmed]
PHST- 2018/05/19 06:00 [medline]
AID - 10.15585/mmwr.mm6719a5 [doi]
PST - epublish
SO  - MMWR Morb Mortal Wkly Rep. 2018 May 18;67(19):556-559. doi:
      10.15585/mmwr.mm6719a5.