PMID- 29768284
OWN - NLM
STAT- MEDLINE
DCOM- 20190201
LR  - 20190201
IS  - 1473-5636 (Electronic)
IS  - 0960-8931 (Linking)
VI  - 28
IP  - 4
DP  - 2018 Aug
TI  - Predictive value of excision repair cross-complementing group 2 gene Lys751Gln
      and Asp312Asn polymorphisms in melanoma risk.
PG  - 311-318
LID - 10.1097/CMR.0000000000000463 [doi]
AB  - Epidemiological studies have assessed the association between excision repair
      cross-complementing group 2 (ERCC2) Lys751Gln and Asp312Asn polymorphisms and
      melanoma risk with conflicting results. Relevant articles were searched from
      PubMed, Embase, and Web of Science with a time limit of 3 September 2016. Pooled 
      odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength
      of the association. We performed this meta-analysis with 12 studies including
      6157 cases and 8873 controls for Lys751Gln and nine studies including 5037 cases 
      and 7542 controls for Asp312Asn polymorphism. Overall, no significant
      associations were found under all the models for Lys751Gln polymorphism, and
      significant associations were found for Asp312Asn polymorphism for AA versus GG
      (OR=1.12, 95% CI=1.00-1.26) and for the recessive model (OR=1.11, 95%
      CI=1.00-1.24). In the stratification analyses by source of control: for Lys751Gln
      polymorphism, significant associations were found for CC versus AA (OR=1.19, 95% 
      CI=1.04-1.36) and the recessive model (OR=1.15, 95% CI=1.02-1.30); for Asp312Asn 
      polymorphism, significant associations were found for AA versus GG (OR=1.31, 95% 
      CI=1.11-1.53) and the recessive model (OR=1.29, 95% CI=1.11-1.50). This
      meta-analysis suggested that both the Lys751Gln and Asp312Asn polymorphisms were 
      risk factors for melanoma risk in population-based subgroup.
FAU - Zhou, Xue
AU  - Zhou X
AD  - Department of Gynaecology, The Fourth People's Hospital of Shanghai.
FAU - Zeng, Yong
AU  - Zeng Y
AD  - Department of Cardiothoracic Surgery, Shaoxing People's Hospital, Shaoxing
      Hospital of Zhejiang University, Shaoxing.
FAU - Jiang, Huayong
AU  - Jiang H
AD  - Department of Radiation Oncology, PLA Army General Hospital, Dongchen, Beijing,
      China.
FAU - Xia, Limei
AU  - Xia L
AD  - Department of Gynaecology, The Fourth People's Hospital of Shanghai.
FAU - Liu, Chuan
AU  - Liu C
AD  - Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - England
TA  - Melanoma Res
JT  - Melanoma research
JID - 9109623
RN  - EC 3.6.4.12 (Xeroderma Pigmentosum Group D Protein)
RN  - EC 5.99.- (ERCC2 protein, human)
SB  - IM
MH  - Case-Control Studies
MH  - DNA Repair
MH  - Humans
MH  - Melanoma/*genetics/pathology
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Skin Neoplasms/*genetics/pathology
MH  - Xeroderma Pigmentosum Group D Protein/*genetics
EDAT- 2018/05/17 06:00
MHDA- 2019/02/02 06:00
CRDT- 2018/05/17 06:00
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2019/02/02 06:00 [medline]
PHST- 2018/05/17 06:00 [entrez]
AID - 10.1097/CMR.0000000000000463 [doi]
PST - ppublish
SO  - Melanoma Res. 2018 Aug;28(4):311-318. doi: 10.1097/CMR.0000000000000463.