PMID- 29754656
OWN - NLM
STAT- In-Process
LR  - 20190414
IS  - 1097-6744 (Electronic)
IS  - 0002-8703 (Linking)
VI  - 199
DP  - 2018 May
TI  - The prognostic value of heart rate recovery in patients with coronary artery
      disease: A systematic review and meta-analysis.
PG  - 163-169
LID - S0002-8703(18)30051-6 [pii]
LID - 10.1016/j.ahj.2018.02.008 [doi]
AB  - BACKGROUND: Routine outpatient care of patients with coronary artery disease
      (CAD) lacks a simple measure of physical fitness and risk of mortality. Heart
      rate recovery (HRR) is noninvasive and easily obtainable in outpatient settings. 
      Prior studies have suggested that delayed postexercise HRR in the first minutes
      is associated with mortality in several types of populations. However, a
      comprehensive overview of the prognostic value of delayed HRR for time to
      mortality specifically in CAD patients is not available. The purpose of the
      current meta-analysis is to evaluate the prognostic value of delayed HRR in CAD
      patients. METHODS: We conducted a systematic search in OVID MEDLINE and OVID
      EMBASE to identify studies reporting on HRR and risk of incident cardiovascular
      events or mortality in CAD patients. Hazard ratios for delayed versus nondelayed 
      HRR were pooled using random-effects meta-analysis. RESULTS: Four studies were
      included, comprising 2,428 CAD patients. The study quality of the included
      studies was rated moderate (n = 2) to high (n = 2). Delayed HRR was defined by
      </=12 to </=21 beat/min in the recovery period. During follow-up (range 2.0-9.8
      years), 151 patients died (6.2% [range 2.5%-19.5%]). Only data on mortality could
      be pooled. Heterogeneity was limited (I(2) = 32%; P = .23); pooled unadjusted
      hazard ratio for mortality, based on 3 studies, was 5.8 (95% CI 3.2-10.4).
      CONCLUSIONS: In CAD patients, delayed HRR is significantly associated with
      all-cause mortality. As exercise testing is performed routinely in CAD patients, 
      HRR can be considered in monitoring exercise; still, further research must
      investigate the addition of HRR in current risk scores.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Lachman, Sangeeta
AU  - Lachman S
AD  - Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands.
      Electronic address: sangeeta.lachman@gmail.com.
FAU - Terbraak, Michel S
AU  - Terbraak MS
AD  - Achieve Amsterdam University of Applied Sciences, Amsterdam, the Netherlands.
FAU - Limpens, Jacqueline
AU  - Limpens J
AD  - Medical Library, Academic Medical Center, Amsterdam, the Netherlands.
FAU - Jorstad, Harald
AU  - Jorstad H
AD  - Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands.
FAU - Lucas, Cees
AU  - Lucas C
AD  - Department of Biostatistics, Academic Medical Center, Amsterdam, the Netherlands.
FAU - Scholte Op Reimer, Wilma
AU  - Scholte Op Reimer W
AD  - Achieve Amsterdam University of Applied Sciences, Amsterdam, the Netherlands.
FAU - Boekholdt, S Matthijs
AU  - Boekholdt SM
AD  - Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands.
FAU - Ter Riet, Gerben
AU  - Ter Riet G
AD  - Achieve Amsterdam University of Applied Sciences, Amsterdam, the Netherlands;
      Department of General Practice, Academic Medical Center, Amsterdam, the
      Netherlands.
FAU - Peters, Ron J G
AU  - Peters RJG
AD  - Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180213
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
EDAT- 2018/05/15 06:00
MHDA- 2018/05/15 06:00
CRDT- 2018/05/15 06:00
PHST- 2017/06/06 00:00 [received]
PHST- 2018/02/07 00:00 [accepted]
PHST- 2018/05/15 06:00 [entrez]
PHST- 2018/05/15 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
AID - S0002-8703(18)30051-6 [pii]
AID - 10.1016/j.ahj.2018.02.008 [doi]
PST - ppublish
SO  - Am Heart J. 2018 May;199:163-169. doi: 10.1016/j.ahj.2018.02.008. Epub 2018 Feb
      13.