PMID- 29746535
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 5
DP  - 2018
TI  - Gonorrhea, Chlamydia and HIV incidence among female sex workers in Cotonou,
      Benin: A longitudinal study.
PG  - e0197251
LID - 10.1371/journal.pone.0197251 [doi]
AB  - Female sex workers (FSWs) continue to carry a heavy burden of sexually
      transmitted infections (STI). For prevention purposes, there is a need to
      identify most-at-risk subgroups among them. The objective of this longitudinal
      cohort study conducted at Dispensaire IST, Cotonou, Benin, was to assess
      Neisseria gonorrhoeae (NG) / Chlamydia trachomatis (CT) incidence and
      determinants; and HIV incidence among FSWs in presence of STI/HIV risk reduction 
      activities. Overall, 319 adult FSWs were followed quarterly from September 2008
      to March 2012. NG/CT were detected from endocervical swabs by Amplified DNA
      Assays employing Strand displacement amplification technology. HIV testing was
      done on capillary blood using two consecutive rapid diagnostic tests.
      Anderson-Gill proportional hazard models (HR) were used to determine factors
      independently associated with NG/CT incidence. The majority of FSWs were
      HIV-negative (188, 58.9%). There were 6 HIV seroconversions among these 188
      HIV-negative women. HIV incidence (95% Confidence interval, CI) was 1.41
      (0.28-2.54) seroconversions per 100 person-years at risk (PYAR): 6 events / 425.1
      PYAR. Sixty-two out of 319 women experienced 83 new episodes of NG/CT for an
      overall incidence rate (95% CI) of 10.8 (8.17-13.88) events / 100 PYAR. From
      month-24 onwards, HIV-positive women (treated: HR (95%CI): 4.2 (1.60-10.77);
      untreated: HR (95%CI): 4.2 (1.59-11.49) were more likely to acquire NG/CT
      compared to HIV-negative FSWs. Longer duration in sex work (>2 years: HR; 95%CI: 
      0.4 (0.22-0.72)) was protective against NG/CT. Refusal by clients (55.8%) was the
      main reason for non-condom use. Enrolling women from one clinic (Dispensaire IST)
      may have impaired generalizability of the findings. New NG/CT/HIV infections were
      observed among FSWs notwithstanding ongoing prevention interventions. To
      eliminate HIV transmission among FSWs, STI/HIV control programs need to promote
      women's empowerment and address vulnerability to infection of HIV-positive FSWs.
FAU - Diabate, Souleymane
AU  - Diabate S
AD  - Axe Sante des populations et pratiques optimales en sante, Centre de recherche du
      CHU de Quebec-Universite Laval, Quebec, Quebec, Canada.
AD  - Departement de medecine sociale et preventive, Universite Laval, Quebec, Quebec, 
      Canada.
AD  - Departement d'infectiologie et sante publique, Universite Alassane Ouattara,
      Bouake, Cote d'Ivoire.
FAU - Chamberland, Annie
AU  - Chamberland A
AD  - Centre de recherche du Centre hospitalier universitaire de Montreal, Montreal,
      Quebec, Canada.
FAU - Geraldo, Nassirou
AU  - Geraldo N
AD  - Dispensaire IST, Centre de sante de Cotonou I, Cotonou, Benin.
FAU - Tremblay, Cecile
AU  - Tremblay C
AUID- ORCID: 0000-0002-3440-3436
AD  - Centre de recherche du Centre hospitalier universitaire de Montreal, Montreal,
      Quebec, Canada.
FAU - Alary, Michel
AU  - Alary M
AUID- ORCID: 0000-0002-0246-4429
AD  - Axe Sante des populations et pratiques optimales en sante, Centre de recherche du
      CHU de Quebec-Universite Laval, Quebec, Quebec, Canada.
AD  - Departement de medecine sociale et preventive, Universite Laval, Quebec, Quebec, 
      Canada.
AD  - Institut national de sante publique du Quebec, Quebec, Quebec, Canada.
LA  - eng
GR  - HPR-85528/Canadian Institutes of Health Research/International
GR  - ROH-115205/Canadian Institutes of Health Research/International
GR  - 188974/Canadian Institutes of Health Research/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180510
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Benin/epidemiology
MH  - Chlamydia Infections/*epidemiology
MH  - *Chlamydia trachomatis
MH  - Female
MH  - Gonorrhea/*epidemiology
MH  - HIV Infections/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Longitudinal Studies
MH  - *Sex Work
MH  - Sex Workers
MH  - Young Adult
PMC - PMC5945000
EDAT- 2018/05/11 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/05/11 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2018/04/30 00:00 [accepted]
PHST- 2018/05/11 06:00 [entrez]
PHST- 2018/05/11 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
AID - 10.1371/journal.pone.0197251 [doi]
AID - PONE-D-17-41673 [pii]
PST - epublish
SO  - PLoS One. 2018 May 10;13(5):e0197251. doi: 10.1371/journal.pone.0197251.
      eCollection 2018.