PMID- 29735544
OWN - NLM
STAT- In-Data-Review
LR  - 20180703
IS  - 1538-7445 (Electronic)
IS  - 0008-5472 (Linking)
VI  - 78
IP  - 13
DP  - 2018 Jul 1
TI  - Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via
      Downregulation of EGFR.
PG  - 3532-3543
LID - 10.1158/0008-5472.CAN-18-0134 [doi]
AB  - A high rate of disease relapse makes epithelial ovarian cancer (EOC) the leading 
      cause of death among all gynecologic malignancies. These relapses are often due
      to tumor dormancy. Here we identify the RNA polymerase II transcriptional
      mediator subunit 12 (MED12) as an important molecular regulator of tumor
      dormancy. MED12 knockout (KO) induced dormancy of EOC cells in vitro and in vivo,
      and microarray analysis showed that MED12 KO decreased expression of EGFR.
      Restoration of EGFR expression in MED12 KO cells restored proliferation.
      Additionally, MED12 bound to the promoter of EGFR, and correlation studies showed
      that MED12 expression positively correlated with EGFR expression in EOC patient
      samples. Clinical data demonstrated that chemotherapy-resistant patients
      expressed lower levels of MED12 compared with responsive patients. Overall, our
      data show that MED12 plays an important role in regulating dormancy of EOC
      through regulation of EGFR.Significance: MED12 is identified as a novel,
      important regulator of tumor dormancy in human ovarian cancer. Cancer Res;
      78(13); 3532-43. (c)2018 AACR.
CI  - (c)2018 American Association for Cancer Research.
FAU - Luo, Xiao-Lin
AU  - Luo XL
AD  - Department of Experimental Research, Sun Yat-sen University Cancer Center, State 
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, Guangzhou, China.
AD  - Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center,
      Guangzhou, China.
FAU - Deng, Cheng-Cheng
AU  - Deng CC
AD  - Department of Experimental Research, Sun Yat-sen University Cancer Center, State 
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, Guangzhou, China.
FAU - Su, Xiao-Dong
AU  - Su XD
AD  - Department of Experimental Research, Sun Yat-sen University Cancer Center, State 
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, Guangzhou, China.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Experimental Research, Sun Yat-sen University Cancer Center, State 
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, Guangzhou, China.
FAU - Chen, Zhen
AU  - Chen Z
AD  - Department of Experimental Research, Sun Yat-sen University Cancer Center, State 
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, Guangzhou, China.
FAU - Wu, Xing-Ping
AU  - Wu XP
AD  - Department of Experimental Research, Sun Yat-sen University Cancer Center, State 
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, Guangzhou, China.
FAU - Liang, Shao-Bo
AU  - Liang SB
AD  - Department of Experimental Research, Sun Yat-sen University Cancer Center, State 
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, Guangzhou, China.
FAU - Liu, Ji-Hong
AU  - Liu JH
AD  - Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center,
      Guangzhou, China. fulw@mail.sysu.edu.cn liujih@mail.sysu.edu.cn.
FAU - Fu, Li-Wu
AU  - Fu LW
AD  - Department of Experimental Research, Sun Yat-sen University Cancer Center, State 
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, Guangzhou, China. fulw@mail.sysu.edu.cn liujih@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180507
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
EDAT- 2018/05/08 06:00
MHDA- 2018/05/08 06:00
CRDT- 2018/05/09 06:00
PHST- 2018/01/13 00:00 [received]
PHST- 2018/03/24 00:00 [revised]
PHST- 2018/04/26 00:00 [accepted]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2018/05/09 06:00 [entrez]
AID - 0008-5472.CAN-18-0134 [pii]
AID - 10.1158/0008-5472.CAN-18-0134 [doi]
PST - ppublish
SO  - Cancer Res. 2018 Jul 1;78(13):3532-3543. doi: 10.1158/0008-5472.CAN-18-0134. Epub
      2018 May 7.