PMID- 29715099
DCOM- 20180515
LR  - 20180515
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 5
DP  - 2018 May
TI  - Clinicopathological Characteristics and KRAS Mutation Status of Endometrial
      Mucinous Metaplasia and Carcinoma.
PG  - 2779-2786
AB  - BACKGROUND/AIM: Mucinous metaplasia of the endometrium occurs as a spectrum of
      epithelial alterations ranging from the formation of simple, tubular glands to
      architecturally complex glandular proliferation with intraglandular papillary
      projection and cellular tufts. Endometrial mucinous metaplasia often presents a
      diagnostic challenge in endometrial curettage. MATERIALS AND METHODS: We analyzed
      the clinicopathological characteristics and the mutation status for V-Ki-ras2
      Kirsten rat sarcoma viral oncogene homolog (KRAS) of 11 cases of endometrial
      mucinous metaplasia. Electronic medical record review and histopathological
      examination were performed. KRAS mutation status was analyzed using a
      pyrosequencing technique. RESULTS: Cases were classified histopathologically into
      simple (5/11) or papillary (6/11) mucinous metaplasias. All (6/6) papillary
      mucinous metaplasias were associated with atypical hyperplasia/endometrioid
      intraepithelial neoplasia (AH/EIN; 1/6) or carcinoma (5/6), whereas in a single
      patient with simple mucinous metaplasia, grade 1 endometrioid carcinoma was
      incidentally detected. The difference in frequency of association of the
      metaplasia with AH/EIN or carcinoma was significant (p=0.015). KRAS mutations
      were identified in five out of six cases of papillary mucinous metaplasias,
      comprising three cases with G12D and two with G12V mutations; the frequency of
      KRAS mutation was significantly higher (p=0.015) than in cases of simple mucinous
      metaplasia (0/5). CONCLUSION: Papillary mucinous metaplasia is frequently
      associated with endometrial neoplastic lesions. The high incidence of KRAS
      mutations in papillary mucinous metaplasia suggests that papillary mucinous
      metaplasia may be a precancerous lesion of a certain subset of mucinous
      carcinomas of the endometrium.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Sung, Ji-Youn
AU  - Sung JY
AD  - Department of Pathology, Kyung Hee University School of Medicine, Seoul, Republic
      of Korea.
FAU - Jung, Yoon Yang
AU  - Jung YY
AD  - Department of Pathology, Myongji Hospital, Goyang, Republic of Korea.
FAU - Kim, Hyun-Soo
AU  - Kim HS
AD  - Department of Pathology, Severance Hospital, Yonsei University College of
      Medicine, Seoul, Republic of Korea
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (KRAS protein, human)
RN  - EC (Proto-Oncogene Proteins p21(ras))
SB  - IM
MH  - Adenocarcinoma, Mucinous/*genetics/pathology
MH  - Adenocarcinoma, Papillary/genetics/pathology
MH  - Adult
MH  - Carcinoma, Endometrioid/genetics/pathology
MH  - Endometrial Neoplasms/*genetics/*pathology
MH  - Female
MH  - Humans
MH  - Metaplasia/genetics/pathology
MH  - Middle Aged
MH  - Precancerous Conditions/genetics/pathology
MH  - Proto-Oncogene Proteins p21(ras)/*genetics
OT  - *Endometrium
OT  - *carcinoma
OT  - *metaplasia
OT  - *mucinous
OT  - *papillary
EDAT- 2018/05/02 06:00
MHDA- 2018/05/16 06:00
CRDT- 2018/05/02 06:00
PHST- 2018/02/23 00:00 [received]
PHST- 2018/03/14 00:00 [revised]
PHST- 2018/03/20 00:00 [accepted]
PHST- 2018/05/02 06:00 [entrez]
PHST- 2018/05/02 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
AID - 38/5/2779 [pii]
AID - 10.21873/anticanres.12521 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 May;38(5):2779-2786. doi: 10.21873/anticanres.12521.