PMID- 29706601
OWN - NLM
STAT- MEDLINE
DCOM- 20190920
LR  - 20190920
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 103
IP  - 2
DP  - 2019 Feb
TI  - Quantifying vascular density and morphology using different swept-source optical 
      coherence tomography angiographic scan patterns in diabetic retinopathy.
PG  - 216-221
LID - 10.1136/bjophthalmol-2018-311942 [doi]
AB  - AIMS: To evaluate quantitative metrics of the retinal microvasculature in eyes
      with diabetic retinopathy (DR) using various en face swept-source optical
      coherence tomography angiography (SS-OCTA) image sizes. METHODS: Non-segmented
      and segmented images were acquired using an SS-OCTA device (PLEX Elite 9000; Carl
      Zeiss Meditec, Dublin, California, USA). The scanning protocols included the 3x3 
      mm, 6x6 mm and 12x12 mm fields of view. Quantitative analysis of the perfusion
      density (PD), vessel length density (VLD) and fractal dimension (FD) was
      performed. The area under the receiver operating characteristic curve was
      estimated to assess the ability of each image size to predict DR. RESULTS: This
      prospective, cross-sectional study included 60 eyes, (non-DR, 13 eyes;
      non-proliferative DR (NPDR), 24 eyes; proliferative DR (PDR), 23 eyes) of 46
      patients with diabetes and 21 eyes of 16 healthy individuals. In the 12x12 mm
      images, the PD of healthy individuals was significantly greater than that of
      patients with NPDR or PDR for all layers (NPDR, p<0.05; PDR, p<0.001 0.001; FD,
      p<0.001) or PDR (VLD, p<0.001; FD, p<0.001 for all layers). The results were
      similar for the 3x3 mm and 6x6 mm images. Overall, PD, VLD and FD progressively
      decreased with worsening DR severity in segmented and non-segmented layers for
      all SS-OCTA scan sizes. For detecting DR, 3x3 mm images best predicted DR for all
      evaluated quantitative parameters. CONCLUSIONS: Vascular changes in DR can be
      monitored in detail through quantitative evaluations that combine different
      SS-OCTA scan sizes and parameters.
CI  - (c) Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and
      permissions. Published by BMJ.
FAU - Hirano, Takao
AU  - Hirano T
AD  - Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California,
      United States.
AD  - Department of Ophthalmology, Shinshu University School of Medicine, Nagano,
      Japan.
FAU - Kitahara, Jyunya
AU  - Kitahara J
AD  - Department of Ophthalmology, Shinshu University School of Medicine, Nagano,
      Japan.
FAU - Toriyama, Yuichi
AU  - Toriyama Y
AD  - Department of Ophthalmology, Shinshu University School of Medicine, Nagano,
      Japan.
FAU - Kasamatsu, Hirotsugu
AU  - Kasamatsu H
AD  - Department of Ophthalmology, Shinshu University School of Medicine, Nagano,
      Japan.
FAU - Murata, Toshinori
AU  - Murata T
AD  - Department of Ophthalmology, Shinshu University School of Medicine, Nagano,
      Japan.
FAU - Sadda, Srinivas
AU  - Sadda S
AD  - Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California,
      United States ssadda@doheny.org.
AD  - Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los
      Angeles, California, United States.
LA  - eng
PT  - Journal Article
DEP - 20180429
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
SB  - IM
MH  - Adult
MH  - Blood Flow Velocity
MH  - Diabetic Retinopathy/diagnostic imaging/*physiopathology
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Macular Edema/diagnostic imaging/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Regional Blood Flow/physiology
MH  - Retinal Vessels/*pathology
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - *Imaging
OT  - *Retina
COIS- Competing interests: SS is a consultant for and receives research support from
      Optos and Carl Zeiss Meditec, serves as a consultant for Centervue, and has
      access to research instruments provided by Heidelberg Engineering, Topcon Medical
      Systems, Optos, Carl Zeiss Meditec, Nidek and Centervue.
EDAT- 2018/05/01 06:00
MHDA- 2019/09/21 06:00
CRDT- 2018/05/01 06:00
PHST- 2018/01/19 00:00 [received]
PHST- 2018/03/09 00:00 [revised]
PHST- 2018/04/05 00:00 [accepted]
PHST- 2018/05/01 06:00 [pubmed]
PHST- 2019/09/21 06:00 [medline]
PHST- 2018/05/01 06:00 [entrez]
AID - bjophthalmol-2018-311942 [pii]
AID - 10.1136/bjophthalmol-2018-311942 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2019 Feb;103(2):216-221. doi: 10.1136/bjophthalmol-2018-311942. 
      Epub 2018 Apr 29.