PMID- 29663442
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20180924
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Linking)
VI  - 41
IP  - 4
DP  - 2018 Apr
TI  - Complexity of scar and ventricular arrhythmias in dilated cardiomyopathy of any
      etiology: Long-term data from the SCARFEAR (Cardiovascular Magnetic Resonance
      Predictors of Appropriate Implantable Cardioverter-Defibrillator Therapy
      Delivery) Registry.
PG  - 494-501
LID - 10.1002/clc.22911 [doi]
AB  - BACKGROUND: Late gadolinium enhancement (LGE) assessed with cardiovascular
      magnetic resonance (CMR) correlates with ventricular arrhythmias and survival in 
      patients with structural heart disease. Whether some LGE characteristics may
      specifically improve prediction of arrhythmic outcomes is unknown. HYPOTHESIS: We
      sought to evaluate scar characteristics assessed with CMR to predict implantable 
      cardioverter-defibrillator (ICD) interventions in dilated cardiomyopathy of
      different etiology. METHODS: 96 consecutive patients evaluated with CMR received 
      an ICD. Biventricular volumes, ejection fraction, and myocardial LGE were
      evaluated. LGE was defined as "complex" (Cx-LGE) in presence of >/=1 of the
      following: ischemic pattern, involving >/=2 different coronary territories;
      epicardial pattern; global endocardial pattern; and presence of >/=2 different
      patterns. The primary endpoint was occurrence of any appropriate ICD
      intervention. A composite secondary endpoint of cardiovascular death, cardiac
      transplantation, or ventricular assist device implantation was also considered.
      RESULTS: During a median follow-up of 75 months, 30 and 25 patients reached the
      primary and secondary endpoints, respectively. Cx-LGE was correlated with a worse
      primary endpoint survival (log-rank P < 0.001). Cx-LGE and right ventricular
      end-diastolic volume were independently associated with the primary endpoint (HR:
      3.22, 95% CI: 1.56-6.65, P = 0.002; and HR: 1.06, 95% CI: 1.00-1.12, P = 0.045,
      respectively), but not with the secondary endpoint. CONCLUSIONS: Cx-LGE
      identified at CMR imaging seems promising as an independent and specific
      prognostic factor of ventricular arrhythmias requiring ICD therapy in dilated
      cardiomyopathy of different etiologies.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Pedretti, Stefano
AU  - Pedretti S
AD  - Electrophysiology Unit, "A De Gasperis" Cardio Center, ASST Grande Ospedale
      Metropolitano Niguarda, Milan, Italy.
AD  - Cardiovascular Magnetic Resonance Service, "A De Gasperis" Cardio Center, ASST
      Grande Ospedale Metropolitano Niguarda, Milan, Italy.
FAU - Vargiu, Sara
AU  - Vargiu S
AD  - Electrophysiology Unit, "A De Gasperis" Cardio Center, ASST Grande Ospedale
      Metropolitano Niguarda, Milan, Italy.
FAU - Baroni, Matteo
AU  - Baroni M
AD  - Electrophysiology Unit, "A De Gasperis" Cardio Center, ASST Grande Ospedale
      Metropolitano Niguarda, Milan, Italy.
FAU - Dellegrottaglie, Santo
AU  - Dellegrottaglie S
AD  - Cardiovascular Magnetic Resonance Service, "A De Gasperis" Cardio Center, ASST
      Grande Ospedale Metropolitano Niguarda, Milan, Italy.
FAU - Lanzarin, Barbara
AU  - Lanzarin B
AD  - Cardiovascular Magnetic Resonance Service, "A De Gasperis" Cardio Center, ASST
      Grande Ospedale Metropolitano Niguarda, Milan, Italy.
FAU - Roghi, Alberto
AU  - Roghi A
AD  - Cardiovascular Magnetic Resonance Service, "A De Gasperis" Cardio Center, ASST
      Grande Ospedale Metropolitano Niguarda, Milan, Italy.
FAU - Milazzo, Angela
AU  - Milazzo A
AD  - Cardiovascular Magnetic Resonance Service, "A De Gasperis" Cardio Center, ASST
      Grande Ospedale Metropolitano Niguarda, Milan, Italy.
FAU - Quattrocchi, Giuseppina
AU  - Quattrocchi G
AD  - Cardiovascular Magnetic Resonance Service, "A De Gasperis" Cardio Center, ASST
      Grande Ospedale Metropolitano Niguarda, Milan, Italy.
FAU - Lunati, Maurizio
AU  - Lunati M
AD  - Electrophysiology Unit, "A De Gasperis" Cardio Center, ASST Grande Ospedale
      Metropolitano Niguarda, Milan, Italy.
FAU - Pedrotti, Patrizia
AU  - Pedrotti P
AD  - Cardiovascular Magnetic Resonance Service, "A De Gasperis" Cardio Center, ASST
      Grande Ospedale Metropolitano Niguarda, Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20180417
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arrhythmias, Cardiac/*diagnostic imaging/etiology/physiopathology/therapy
MH  - Cardiomyopathy, Dilated/*diagnostic imaging/etiology/physiopathology/therapy
MH  - Cicatrix/*diagnostic imaging/etiology/physiopathology/therapy
MH  - *Clinical Decision-Making
MH  - Contrast Media/administration & dosage
MH  - Death, Sudden, Cardiac/etiology/prevention & control
MH  - *Defibrillators, Implantable
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Electric Countershock/*instrumentation
MH  - Female
MH  - Gadolinium DTPA/administration & dosage
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Predictive Value of Tests
MH  - Recovery of Function
MH  - Registries
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - ICD therapy
OT  - cardiovascular magnetic resonance
OT  - myocardial fibrosis
OT  - sudden cardiac death
EDAT- 2018/04/18 06:00
MHDA- 2018/09/25 06:00
CRDT- 2018/04/18 06:00
PHST- 2017/12/18 00:00 [received]
PHST- 2018/01/22 00:00 [revised]
PHST- 2018/01/25 00:00 [accepted]
PHST- 2018/04/18 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2018/04/18 06:00 [entrez]
AID - 10.1002/clc.22911 [doi]
PST - ppublish
SO  - Clin Cardiol. 2018 Apr;41(4):494-501. doi: 10.1002/clc.22911. Epub 2018 Apr 17.