PMID- 29598944
OWN - NLM
STAT- In-Data-Review
LR  - 20190402
IS  - 1879-0593 (Electronic)
IS  - 1368-8375 (Linking)
VI  - 79
DP  - 2018 Apr
TI  - Three-dimensional imaging assessment of anatomic invasion and volumetric
      considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx
      cancer.
PG  - 1-8
LID - S1368-8375(18)30032-0 [pii]
LID - 10.1016/j.oraloncology.2018.01.025 [doi]
AB  - OBJECTIVES: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and
      extent of involvement of primary tumor on treatment outcomes in a large uniform
      cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal
      preservation strategies. MATERIALS AND METHODS: The pretreatment
      contrast-enhanced computed tomography images of 90 patients with T3 laryngeal
      carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to
      calculate the 3D TV and define the extent of invasion. Cartilage and soft tissue 
      involvement was coded. The extent of invasion was dichotomized into non/limited
      invasion versus multiple invasion extension (MIE), and was subsequently
      correlated with survival outcomes. RESULTS: The median TV was 6.6cm(3).
      Sixty-five patients had non/limited invasion, and 25 had MIE. Median follow-up
      for surviving patients was 52months. The 5-year local control and overall
      survival rates for the whole cohort were 88% and 68%, respectively. There was no 
      correlation between TV and survival outcomes. However, patients with non/limited 
      invasion had better 5-year local control (LC) than those with MIE (95% vs 72%,
      p=.009) but did not have a significantly higher rate of overall survival (OS)
      (74% vs 67%, p=.327). In multivariate correlates of LC, MIE maintained
      statistical significance whereas baseline airway status showed a statistically
      significance trend with poor LC (p=.0087 and 0.06, respectively). Baseline good
      performance status was an independent predictor of improved OS (p=.03) in
      multivariate analysis. CONCLUSION: The extent of primary tumor invasion is an
      independent prognostic factor of LC of the disease after definitive radiotherapy 
      in T3 larynx cancer.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Kamal, Mona
AU  - Kamal M
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA; Department of Clinical Oncology and Nuclear Medicine,
      Faculty of Medicine, Ain Shams University, Cairo, Egypt.
FAU - Ng, Sweet Ping
AU  - Ng SP
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Eraj, Salman A
AU  - Eraj SA
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA; School of Medicine, The University of Texas Health
      Science Center at Houston, McGovern School of Medicine, Houston, TX, USA.
FAU - Rock, Crosby D
AU  - Rock CD
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA; School of Medicine, Texas Tech University Health
      Sciences Center, Paul L. Foster School of Medicine, El Paso, TX, USA.
FAU - Pham, Brian
AU  - Pham B
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Messer, Jay A
AU  - Messer JA
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA; Department of Radiation Oncology, The University of
      Texas Medical Branch, Galveston, TX, USA.
FAU - Garden, Adam S
AU  - Garden AS
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Morrison, William H
AU  - Morrison WH
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Phan, Jack
AU  - Phan J
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Frank, Steven J
AU  - Frank SJ
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - El-Naggar, Adel K
AU  - El-Naggar AK
AD  - Department of Pathology, Division of Pathology/Lab Medicine, The University of
      Texas, MD Anderson Cancer Center, Houston, TX, USA.
FAU - Johnson, Jason M
AU  - Johnson JM
AD  - Department of Radiology, The University of Texas MD Anderson Cancer Center,
      Houston, TX, USA.
FAU - Ginsberg, Lawrence E
AU  - Ginsberg LE
AD  - Department of Radiology, The University of Texas MD Anderson Cancer Center,
      Houston, TX, USA.
FAU - Ferrarotto, Renata
AU  - Ferrarotto R
AD  - Department of Medical Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Lewin, Jan S
AU  - Lewin JS
AD  - Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Hutcheson, Katherine A
AU  - Hutcheson KA
AD  - Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Cardenas, Carlos E
AU  - Cardenas CE
AD  - Department of Radiation Physics, The University of Texas MD Anderson Cancer
      Center, Houston, USA.
FAU - Zafereo, Mark E
AU  - Zafereo ME
AD  - Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Lai, Stephen Y
AU  - Lai SY
AD  - Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Hessel, Amy C
AU  - Hessel AC
AD  - Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Weber, Randal S
AU  - Weber RS
AD  - Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Gunn, G Brandon
AU  - Gunn GB
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA.
FAU - Fuller, Clifton D
AU  - Fuller CD
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA; Cancer Biology Program, The University of Texas
      Graduate School of Biomedical Sciences, Houston, TX, USA.
FAU - Mohamed, Abdallah S R
AU  - Mohamed ASR
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA; Cancer Biology Program, The University of Texas
      Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Clinical 
      Oncology and Nuclear Medicine, Faculty of Medicine, University of Alexandria,
      Alexandria, Egypt. Electronic address: ASMohamed@mdanderson.org.
FAU - Rosenthal, David I
AU  - Rosenthal DI
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer
      Center, Houston, TX, USA. Electronic address: dirosenthal@mdanderson.org.
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - P50 CA097007/CA/NCI NIH HHS/United States
GR  - R01 DE025248/DE/NIDCR NIH HHS/United States
GR  - R01 CA214825/CA/NCI NIH HHS/United States
GR  - R01 CA218148/CA/NCI NIH HHS/United States
GR  - R01 CA225190/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20180210
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
PMC - PMC5880303
MID - NIHMS943915
OTO - NOTNLM
OT  - Chemoradiotherapy
OT  - Laryngeal preservation
OT  - Radiation therapy
OT  - T3 laryngeal cancer
OT  - Tumor volume
EDAT- 2018/03/31 06:00
MHDA- 2018/03/31 06:00
CRDT- 2018/03/31 06:00
PHST- 2017/10/20 00:00 [received]
PHST- 2018/01/07 00:00 [revised]
PHST- 2018/01/26 00:00 [accepted]
PHST- 2018/03/31 06:00 [entrez]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2018/03/31 06:00 [medline]
AID - S1368-8375(18)30032-0 [pii]
AID - 10.1016/j.oraloncology.2018.01.025 [doi]
PST - ppublish
SO  - Oral Oncol. 2018 Apr;79:1-8. doi: 10.1016/j.oraloncology.2018.01.025. Epub 2018
      Feb 10.