PMID- 29590197
OWN - NLM
STAT- MEDLINE
DCOM- 20180724
LR  - 20181114
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 3
DP  - 2018
TI  - Correlation between coronary artery calcification by non-cardiac CT and
      Framingham score in young patients.
PG  - e0195061
LID - 10.1371/journal.pone.0195061 [doi]
AB  - BACKGROUND: Previous studies have established a correlation between coronary
      artery calcification (CAC) measured by ECG-gated chest computed tomography (CT)
      and cardiovascular disease. Recent reports which included asymptomatic patients
      suggest that CAC measured on non-ECG gated CT is similarly associated with
      cardiovascular risk. This study investigates the correlation between the
      Framingham Risk Score (FRS) and an incidental finding of CAC on a non-gated chest
      CT performed for non-cardiac indications in young and seemingly healthy adults.
      METHODS: A cross-sectional study that included 162 CT scans performed in young
      patients aged 18-50 years old for non-cardiac indications in our institution was 
      conducted. CAC score (CACS) was calculated using the Agatston method. FRS was
      calculated and compared to the CACS using three different approaches. The
      correlations between the CACS and several specific factors (i.e. age, body mass
      index, smoking, statins, etc.), were also evaluated. RESULTS: Mean age of
      patients was 36.43 year old and 105 (64.8%) were male. We found a significant
      positive correlation between the CACS and the FRS in all three approaches
      (p<0.05). Increased age, smoking and statin use were the only individual factors 
      clearly associated with an increase in CACS (p = 0.002, p = 0.045 and p = 0.009, 
      respectively). CONCLUSION: This is the first report indicating that incidental
      CACS identified in non-gated MDCT is also associated with cardiovascular risk
      evaluated by FRS in a young population. Our findings suggest that young
      asymptomatic individuals with incidental CAC should be seriously evaluated for
      cardiovascular risk factors despite presumption of belonging to a low
      cardiovascular risk category.
FAU - Lichtenstein, Gabriel
AU  - Lichtenstein G
AD  - Center for Research, Prevention and Treatment of Atherosclerosis, Hadassah-Hebrew
      University Medical Center, Jerusalem, Israel.
FAU - Perlman, Amichai
AU  - Perlman A
AD  - Internal Medicine Ward, Hadassah-Hebrew University Medical Center, Jerusalem,
      Israel.
FAU - Shpitzen, Shoshana
AU  - Shpitzen S
AD  - Center for Research, Prevention and Treatment of Atherosclerosis, Hadassah-Hebrew
      University Medical Center, Jerusalem, Israel.
FAU - Durst, Ronen
AU  - Durst R
AD  - Center for Research, Prevention and Treatment of Atherosclerosis, Hadassah-Hebrew
      University Medical Center, Jerusalem, Israel.
AD  - Heart Institute, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
FAU - Shaham, Dorit
AU  - Shaham D
AD  - Medical Imaging Department, Hadassah-Hebrew University Medical Center, Jerusalem,
      Israel.
FAU - Leitersdorf, Eran
AU  - Leitersdorf E
AD  - Center for Research, Prevention and Treatment of Atherosclerosis, Hadassah-Hebrew
      University Medical Center, Jerusalem, Israel.
AD  - Internal Medicine Ward, Hadassah-Hebrew University Medical Center, Jerusalem,
      Israel.
FAU - Szalat, Auryan
AU  - Szalat A
AUID- ORCID: 0000-0003-3339-4408
AD  - Center for Research, Prevention and Treatment of Atherosclerosis, Hadassah-Hebrew
      University Medical Center, Jerusalem, Israel.
AD  - Internal Medicine Ward, Hadassah-Hebrew University Medical Center, Jerusalem,
      Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180328
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*diagnosis/diagnostic imaging/etiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Incidental Findings
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Tomography, X-Ray Computed/*methods
MH  - Vascular Calcification/*complications/diagnostic imaging
MH  - Young Adult
PMC - PMC5874063
EDAT- 2018/03/29 06:00
MHDA- 2018/07/25 06:00
CRDT- 2018/03/29 06:00
PHST- 2017/10/15 00:00 [received]
PHST- 2018/03/15 00:00 [accepted]
PHST- 2018/03/29 06:00 [entrez]
PHST- 2018/03/29 06:00 [pubmed]
PHST- 2018/07/25 06:00 [medline]
AID - 10.1371/journal.pone.0195061 [doi]
AID - PONE-D-17-36970 [pii]
PST - epublish
SO  - PLoS One. 2018 Mar 28;13(3):e0195061. doi: 10.1371/journal.pone.0195061.
      eCollection 2018.