PMID- 29574967
OWN - NLM
STAT- MEDLINE
DCOM- 20190123
LR  - 20190123
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 143
IP  - 4
DP  - 2018 Aug 15
TI  - Is the incidence of advanced-stage breast cancer affected by whether women attend
      a steady-state screening program?
PG  - 842-850
LID - 10.1002/ijc.31388 [doi]
AB  - In this cross-sectional population-based study, we assessed the incidence of
      advanced breast cancer based on screening attendance. Women from the Netherlands 
      Cancer Registry were included if aged >/=49 years and diagnosed with breast
      cancer between 2006 and 2011, and data were linked with the screening program.
      Cancers were defined as screen-related (diagnosed <24 months after screening) or 
      nonscreened (all other breast cancers). Two cut-offs were used to define advanced
      breast cancer: TNM-stage (III-IV vs 0-I-II) and T-stage alone (>/=15 mm vs <15 mm
      or DCIS). The incidence rates were adjusted for age and logistic regression was
      used to compare groups. Of the 72,612 included women diagnosed with breast
      cancer, 44,246 (61%) had screen-related breast cancer. By TNM stage, advanced
      cancer was almost three times as likely to be at an advanced TNM stage in the
      nonscreened group compared with the screen-related group (38 and 94 per 100,000, 
      respectively; OR: 2.86, 95%CI: 2.72-3.00). By T-stage, the incidence of advanced 
      cancer was higher overall, and in nonscreened women was significantly higher than
      in screened women (210 and 169 per 100,000; OR: 1.85, 95%CI: 1.78-1.93). Data on 
      actual screening attendance showed that the incidence of advanced breast cancer
      was significantly higher in nonscreened women than in screened women, supporting 
      the expectation that screening would cause a stage shift to early detection.
      Despite critical evaluations of breast cancer screening programs, our data show
      that breast cancer screening is a valuable tool that can reduce the disease
      burden in women.
CI  - (c) 2018 UICC.
FAU - de Munck, Linda
AU  - de Munck L
AUID- ORCID: 0000-0002-2930-509X
AD  - Department of Research, Netherlands Comprehensive Cancer Organisation, Utrecht,
      The Netherlands.
AD  - Department of Epidemiology, University of Groningen, University Medical Center
      Groningen, Groningen, The Netherlands.
FAU - Fracheboud, Jacques
AU  - Fracheboud J
AD  - Department of Public Health, Erasmus MC, University Medical Center Rotterdam,
      Rotterdam, The Netherlands.
FAU - de Bock, Geertruida H
AU  - de Bock GH
AD  - Department of Epidemiology, University of Groningen, University Medical Center
      Groningen, Groningen, The Netherlands.
FAU - den Heeten, Gerard J
AU  - den Heeten GJ
AD  - Dutch Reference Centre for Screening, Nijmegen, The Netherlands.
AD  - Department of Radiology, Academic Medical Centre Amsterdam, Amsterdam, The
      Netherlands.
FAU - Siesling, Sabine
AU  - Siesling S
AD  - Department of Research, Netherlands Comprehensive Cancer Organisation, Utrecht,
      The Netherlands.
AD  - Department of Health Technology & Services Research, MIRA Institute for
      Biomedical Technology and Technical Medicine, University of Twente, Enschede, The
      Netherlands.
FAU - Broeders, Mireille J M
AU  - Broeders MJM
AUID- ORCID: 0000-0002-8741-8148
AD  - Dutch Reference Centre for Screening, Nijmegen, The Netherlands.
AD  - Radboud Institute for Health Sciences, Radboud University Medical Center,
      Nijmegen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20180406
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*diagnosis/*epidemiology/pathology
MH  - Cross-Sectional Studies
MH  - Early Detection of Cancer/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Mammography
MH  - Mass Screening/*statistics & numerical data
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Netherlands/epidemiology
MH  - Registries
OTO - NOTNLM
OT  - *advanced-stage
OT  - *breast cancer
OT  - *incidence rate
OT  - *mass screening
OT  - *screen-detected
EDAT- 2018/03/27 06:00
MHDA- 2019/01/24 06:00
CRDT- 2018/03/26 06:00
PHST- 2017/08/25 00:00 [received]
PHST- 2018/02/26 00:00 [revised]
PHST- 2018/02/28 00:00 [accepted]
PHST- 2018/03/27 06:00 [pubmed]
PHST- 2019/01/24 06:00 [medline]
PHST- 2018/03/26 06:00 [entrez]
AID - 10.1002/ijc.31388 [doi]
PST - ppublish
SO  - Int J Cancer. 2018 Aug 15;143(4):842-850. doi: 10.1002/ijc.31388. Epub 2018 Apr
      6.