PMID- 29572831
OWN - NLM
STAT- MEDLINE
DCOM- 20181106
LR  - 20181106
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 143
IP  - 1
DP  - 2018 Oct
TI  - The impact of proteinuria on maternal and perinatal outcomes among women with
      pre-eclampsia.
PG  - 101-107
LID - 10.1002/ijgo.12487 [doi]
AB  - OBJECTIVE: To assess the impact of proteinuria on pregnancy outcomes among women 
      with pre-eclampsia. METHODS: The present retrospective cohort study included
      patients with pre-eclampsia who delivered at a referral maternity hospital in
      Brazil between January 1, 2009, and December 31, 2013. Patients were stratified
      into three groups based on 24-hour urinary protein excretion during pregnancy:
      mild (0.3-<2.0 g), severe (2.0-<5.0 g), and massive (>/=5.0 g). RESULTS: There
      were 293 patients included in the study; 88, 129, and 76 had mild, severe, and
      massive proteinuria, respectively. Chronic hypertension was the most frequent
      pre-existing condition among all women (86 [29.4%]). The mean pregnancy duration 
      at the onset of maternal pre-eclampsia was longest in the mild group compared and
      decreased with increasing proteinuria severity (P<0.001). Preterm delivery was
      recorded among 205 of 293 (70.0%) neonates; there were 66 (22.5%) neonates that
      were preterm and in the massive proteinuria group. The incidence of severe
      pre-eclampsia was lowest in the mild proteinuria group (P=0.002) and tended to
      occur at 34 weeks. Cesarean delivery rates exceeded 80.0% in all groups. Most
      patients assessed at 40-60 days postpartum remained proteinuric (40/61[66%]).
      CONCLUSIONS: Quantifying the severity of proteinuria could identify a subgroup of
      women with pre-eclampsia at increased risk of adverse outcomes.
CI  - (c) 2018 International Federation of Gynecology and Obstetrics.
FAU - Guida, Jose P
AU  - Guida JP
AD  - Department of Obstetrics and Gynecology, School of Medical Sciences, University
      of Campinas, Campinas, Brazil.
FAU - Parpinelli, Mary A
AU  - Parpinelli MA
AD  - Department of Obstetrics and Gynecology, School of Medical Sciences, University
      of Campinas, Campinas, Brazil.
FAU - Surita, Fernanda G
AU  - Surita FG
AD  - Department of Obstetrics and Gynecology, School of Medical Sciences, University
      of Campinas, Campinas, Brazil.
FAU - Costa, Maria L
AU  - Costa ML
AD  - Department of Obstetrics and Gynecology, School of Medical Sciences, University
      of Campinas, Campinas, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180411
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Adult
MH  - Brazil/epidemiology
MH  - *Cesarean Section
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Pre-Eclampsia/epidemiology/*physiopathology
MH  - Pregnancy
MH  - *Pregnancy Outcome
MH  - Proteinuria/*physiopathology
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Eclampsia
OT  - HELLP syndrome
OT  - Kidney
OT  - Pre-eclampsia
OT  - Pregnancy
OT  - Proteinuria
EDAT- 2018/03/25 06:00
MHDA- 2018/11/07 06:00
CRDT- 2018/03/25 06:00
PHST- 2017/11/01 00:00 [received]
PHST- 2017/12/20 00:00 [revised]
PHST- 2018/03/16 00:00 [accepted]
PHST- 2018/03/25 06:00 [pubmed]
PHST- 2018/11/07 06:00 [medline]
PHST- 2018/03/25 06:00 [entrez]
AID - 10.1002/ijgo.12487 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2018 Oct;143(1):101-107. doi: 10.1002/ijgo.12487. Epub
      2018 Apr 11.