PMID- 29571849
OWN - NLM
STAT- In-Data-Review
LR  - 20180324
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 387
DP  - 2018 Apr 15
TI  - Oligoclonal bands and periventricular lesions in multiple sclerosis will not
      increase blood-brain barrier permeability.
PG  - 129-133
LID - S0022-510X(18)30078-9 [pii]
LID - 10.1016/j.jns.2018.02.020 [doi]
AB  - OBJECTIVE: To elucidate the etiology and clinical significance of periventricular
      lesions (PVLs) and oligoclonal bands (OB) in multiple sclerosis (MS). METHODS: We
      enrolled a total of 97 MS patients (67 OB-positive and 30 OB-negative) who were
      negative both for anti-aquaporin-4 (AQP4) autoantibody and anti-myelin
      oligodendrocyte glycoprotein (MOG) antibody. In these patients, comprehensive
      data including clinical, laboratory, and MRI were collected to investigate the
      significance of OB and PVLs. RESULTS: Within the MS patients, OB-positivity and
      the number of PVLs were associated each other. Both of OB-positivity and PVLs did
      not affect clinical severity or relapse rate, though the patients with >/=3 PVLs 
      showed faster cerebral atrophy than those with <3 PVLs. The patients with OB or
      >/=3 PVLs showed lower values of quotient of albumin (QAlb), a biomarker of
      blood-brain barrier (BBB)-permeability and possibly reflects the ongoing disease 
      activity, and lower protein levels in cerebrospinal fluid (CSF). The causal
      relationship between the decreased QAlb and OB or >/=3 PVLs was not determined.
      CONCLUSIONS: OB and PVLs were associated each other, but they did not affect the 
      clinical course or increased the BBB-permeability within MS patients.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Akaishi, Tetsuya
AU  - Akaishi T
AD  - Department of Neurology, Tohoku University Graduate School of Medicine, Japan;
      Department of Neurology, National Hospital Organization Yonezawa Hospital, Japan.
      Electronic address: t-akaishi@med.tohoku.ac.jp.
FAU - Takahashi, Toshiyuki
AU  - Takahashi T
AD  - Department of Neurology, Tohoku University Graduate School of Medicine, Japan;
      Department of Neurology, National Hospital Organization Yonezawa Hospital, Japan.
      Electronic address: t-toshiyuki@mta.biglobe.ne.jp.
FAU - Nakashima, Ichiro
AU  - Nakashima I
AD  - Department of Neurology, Tohoku Medical and Pharmaceutical University, Japan.
      Electronic address: nakashima@hosp.tohoku-mpu.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20180206
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
OTO - NOTNLM
OT  - Barkhof's criteria
OT  - Blood-brain barrier
OT  - Multiple sclerosis
OT  - Oligoclonal bands
OT  - Periventricular lesions
EDAT- 2018/03/25 06:00
MHDA- 2018/03/25 06:00
CRDT- 2018/03/25 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2018/02/05 00:00 [revised]
PHST- 2018/02/05 00:00 [accepted]
PHST- 2018/03/25 06:00 [entrez]
PHST- 2018/03/25 06:00 [pubmed]
PHST- 2018/03/25 06:00 [medline]
AID - S0022-510X(18)30078-9 [pii]
AID - 10.1016/j.jns.2018.02.020 [doi]
PST - ppublish
SO  - J Neurol Sci. 2018 Apr 15;387:129-133. doi: 10.1016/j.jns.2018.02.020. Epub 2018 
      Feb 6.