PMID- 29544927
OWN - NLM
STAT- MEDLINE
DCOM- 20181025
LR  - 20181025
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 258
DP  - 2018 May 1
TI  - Pregnancy and newborn outcomes in arrhythmogenic right ventricular
      cardiomyopathy/dysplasia.
PG  - 172-178
LID - S0167-5273(17)33404-6 [pii]
LID - 10.1016/j.ijcard.2017.11.067 [doi]
AB  - INTRODUCTION: The prognosis of pregnancy in patients with Arrhythmogenic Right
      Ventricular Cardiomyopathy/dysplasia (ARVC/D) is poorly documented. The aim of
      this study is to assess the cardiac risks during pregnancy and the impact of
      ARVC/D on fetuses/neonates/children. METHODS: We included all ARVC/D women with a
      history of pregnancy from the ARVC/D Pitie-Salpetriere registry. Cardiac and
      obstetrical events having occurred during pregnancy/delivery/post-partum periods 
      and neonatal data/follow-up were collected. RESULTS: Sixty pregnancies in
      twenty-three patients were identified between 1968 and 2016. Only two major
      non-fatal cardiac events (one sustained non-documented tachycardia and one
      ventricular tachycardia) were recorded during pregnancy in two different mothers 
      (3% of pregnancies, 9% of mothers). None occurred during delivery or in the
      postpartum period. No mother developed heart failure. Beta-blocker therapy during
      pregnancy (n=15) was associated with lower birthweight (2730 vs 3400g, p=0.004). 
      Only two preterm deliveries occurred, unrelated to cardiac condition. Caesarean
      section was performed in 13% of cases. Premature sudden-death occurred in 10%
      (n=5) of children before 25years-old including two in the first year of life.
      CONCLUSION: ARVC/D is associated with a low rate of major cardiac events during
      pregnancy and vaginal delivery appears safe. The risk of sustained ventricular
      arrhythmia seems poorly predictable and supports the continuation of
      beta-blockers during pregnancy. Major cardiac events were frequent in childhood, 
      justifying close cardiac monitoring.
CI  - Copyright (c) 2017 Elsevier Ireland Ltd. All rights reserved.
FAU - Gandjbakhch, E
AU  - Gandjbakhch E
AD  - Assistance Publique-Hopitaux de Paris, Hopital Pitie-Salpetriere, ICAN, Institut 
      de Cardiologie, F-75013 Paris, France; Centre de Reference Pour les Maladies
      Cardiaques Hereditaires, APHP, ICAN, Hopital de la Pitie Salpetriere, F-75013
      Paris, France; Sorbonne Universites, UPMC Univ Paris 06 Faculte de Medecine,
      Paris, France. Electronic address: estelle.gandjbakhch@aphp.fr.
FAU - Varlet, E
AU  - Varlet E
AD  - Assistance Publique-Hopitaux de Paris, Hopital Bichat-Claude Bernard, F-75018,
      Departement de Cardiologie, Paris, France.
FAU - Duthoit, G
AU  - Duthoit G
AD  - Assistance Publique-Hopitaux de Paris, Hopital Pitie-Salpetriere, ICAN, Institut 
      de Cardiologie, F-75013 Paris, France; Centre de Reference Pour les Maladies
      Cardiaques Hereditaires, APHP, ICAN, Hopital de la Pitie Salpetriere, F-75013
      Paris, France.
FAU - Fressart, V
AU  - Fressart V
AD  - Centre de Reference Pour les Maladies Cardiaques Hereditaires, APHP, ICAN,
      Hopital de la Pitie Salpetriere, F-75013 Paris, France; Assistance
      Publique-Hopitaux de Paris, Hopital Pitie-Salpetriere, Departement de Biochimie
      Metabolique, Cardiogenetique, F-75013 Paris, France.
FAU - Charron, P
AU  - Charron P
AD  - Centre de Reference Pour les Maladies Cardiaques Hereditaires, APHP, ICAN,
      Hopital de la Pitie Salpetriere, F-75013 Paris, France; Universite Versailles
      Saint Quentin & AP-, HP, Service de Genetique, Hopital Ambroise Pare,
      Boulogne-Billancourt, France.
FAU - Himbert, C
AU  - Himbert C
AD  - Assistance Publique-Hopitaux de Paris, Hopital Pitie-Salpetriere, ICAN, Institut 
      de Cardiologie, F-75013 Paris, France.
FAU - Maupain, C
AU  - Maupain C
AD  - Assistance Publique-Hopitaux de Paris, Hopital Pitie-Salpetriere, ICAN, Institut 
      de Cardiologie, F-75013 Paris, France; Centre de Reference Pour les Maladies
      Cardiaques Hereditaires, APHP, ICAN, Hopital de la Pitie Salpetriere, F-75013
      Paris, France.
FAU - Bordet, C
AU  - Bordet C
AD  - Centre de Reference Pour les Maladies Cardiaques Hereditaires, APHP, ICAN,
      Hopital de la Pitie Salpetriere, F-75013 Paris, France.
FAU - Hidden-Lucet, F
AU  - Hidden-Lucet F
AD  - Assistance Publique-Hopitaux de Paris, Hopital Pitie-Salpetriere, ICAN, Institut 
      de Cardiologie, F-75013 Paris, France; Centre de Reference Pour les Maladies
      Cardiaques Hereditaires, APHP, ICAN, Hopital de la Pitie Salpetriere, F-75013
      Paris, France.
FAU - Nizard, J
AU  - Nizard J
AD  - Sorbonne Universites, UPMC Univ Paris 06 Faculte de Medecine, Paris, France;
      Service de Gynecologie Obstetrique, APHP, Hopital de la Pitie Salpetriere,
      F-75013 Paris, France.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Adrenergic beta-Antagonists)
SB  - IM
CIN - Int J Cardiol. 2018 May 1;258:199-200. PMID: 29544930
MH  - Abortion, Spontaneous/diagnostic imaging/epidemiology/prevention & control
MH  - Adrenergic beta-Antagonists/therapeutic use
MH  - Adult
MH  - Arrhythmogenic Right Ventricular Dysplasia/*diagnostic imaging/drug
      therapy/*epidemiology
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Middle Aged
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*diagnostic imaging/drug
      therapy/*epidemiology
MH  - Pregnancy Outcome/*epidemiology
MH  - Premature Birth/diagnostic imaging/epidemiology/prevention & control
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - *ARVC
OT  - *ARVD
OT  - *Cardiomyopathy
OT  - *Pregnancy
OT  - *Ventricular arrhythmias
EDAT- 2018/03/17 06:00
MHDA- 2018/10/26 06:00
CRDT- 2018/03/17 06:00
PHST- 2017/06/06 00:00 [received]
PHST- 2017/11/03 00:00 [revised]
PHST- 2017/11/20 00:00 [accepted]
PHST- 2018/03/17 06:00 [entrez]
PHST- 2018/03/17 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
AID - S0167-5273(17)33404-6 [pii]
AID - 10.1016/j.ijcard.2017.11.067 [doi]
PST - ppublish
SO  - Int J Cardiol. 2018 May 1;258:172-178. doi: 10.1016/j.ijcard.2017.11.067.