PMID- 29521637
OWN - NLM
STAT- MEDLINE
DCOM- 20180829
LR  - 20181202
IS  - 1952-4013 (Electronic)
IS  - 1167-1122 (Linking)
VI  - 28
IP  - 1
DP  - 2018 Feb 1
TI  - Risk factors for lethal outcome in patients with pemphigus: a retrospective
      cohort study.
PG  - 26-37
LID - 10.1684/ejd.2018.3252 [doi]
AB  - Although pemphigus is associated with increased mortality, little is known
      regarding factors that influence prognosis. To identify prognostic factors for
      mortality at five- and 10-year periods after an initial diagnosis of pemphigus. A
      retrospective cohort study was performed. Data were collected for all patients
      with a new diagnosis of pemphigus between 1990 and 2011, who were actively
      followed for at least five years at our centre. The endpoint was overall survival
      at five and 10 years after pemphigus diagnosis. Based on the test sample,
      associations between clinical variables and overall survival were assessed using 
      univariate and multivariate analyses. A total of 184 patients were included in
      the study (mean age: 52.2 +/- 16.1). The major risk factors for lethal outcome at
      both five and 10 years after diagnosis were age >/=65 years at diagnosis (with a 
      multivariate hazard ratio [HR] of 5.9 and 4.2 at five and 10 years, respectively)
      and neurological disease at diagnosis (with a multivariate HR of 5.4 and 5.1 at 5
      and 10 years, respectively). Diabetes mellitus was an independent risk factor for
      mortality at five years (multivariate HR: 3.8). Two risk factors were
      independently associated with lethal outcome at 10 years: serum albumin levels
      <3.5 g/dL (multivariate HR: 3.3) and lung disease at diagnosis (multivariate HR: 
      3.8). Mucosal involvement in patients with pemphigus vulgaris was not associated 
      with increased mortality. Prognosis of patients with pemphigus is influenced by
      older age, hypoalbuminaemia, diabetes mellitus, and neurological and respiratory 
      comorbidities at diagnosis.
FAU - Kridin, Khalaf
AU  - Kridin K
AD  - Department of Dermatology, Rambam Health Care Campus.
FAU - Zelber-Sagi, Shira
AU  - Zelber-Sagi S
AD  - School of Public Health, Faculty of Social Welfare and Health Sciences,
      University of Haifa.
FAU - Bergman, Reuven
AU  - Bergman R
AD  - Department of Dermatology, Rambam Health Care Campus,, Rappaport Faculty of
      Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Child
MH  - Child, Preschool
MH  - Comorbidity
MH  - Female
MH  - Genitalia
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Israel/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Pemphigus/drug therapy/immunology/*mortality
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - age
OT  - diabetes mellitus
OT  - diagnosis
OT  - mortality
OT  - neurological and respiratory disease
OT  - overall survival
OT  - pemphigus
OT  - prognosis
OT  - serum albumin
EDAT- 2018/03/10 06:00
MHDA- 2018/08/30 06:00
CRDT- 2018/03/10 06:00
PHST- 2018/03/10 06:00 [entrez]
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2018/08/30 06:00 [medline]
AID - ejd.2018.3252 [pii]
AID - 10.1684/ejd.2018.3252 [doi]
PST - ppublish
SO  - Eur J Dermatol. 2018 Feb 1;28(1):26-37. doi: 10.1684/ejd.2018.3252.