PMID- 29518458
OWN - NLM
STAT- MEDLINE
DCOM- 20181226
LR  - 20181226
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 79
IP  - 2
DP  - 2018 Aug
TI  - The prognostic significance of tumor-infiltrating lymphocytes for primary
      melanoma varies by sex.
PG  - 245-251
LID - S0190-9622(18)30352-9 [pii]
LID - 10.1016/j.jaad.2018.02.066 [doi]
AB  - BACKGROUND: The immune response to melanoma is manifested locally by
      tumor-infiltrating lymphocytes (TILs). Men and women are known to have varying
      patterns of immunity, yet sex-specific prognostic implications of TILs have not
      been explored. METHODS: Patients who had clinically localized primary melanoma
      with a Breslow thickness of 0.76 mm or more and underwent sentinel lymph node
      (SLN) biopsy at our institution were identified. The association between TILs
      (absent, nonbrisk, and brisk) and SLN positivity was evaluated by using logistic 
      regression. Overall survival (OS) was evaluated by TIL status and sex. RESULTS:
      Among 1367 patients identified, 794 were men. TILs were brisk in 143 lesions,
      nonbrisk in 903, and absent in 321, which did not vary by sex (P = .71). SLN
      positivity was associated with TILs among men (brisk, 3.8%; nonbrisk, 16.9%; and 
      absent, 26.6% [P < .001]). In contrast, there was no association between SLN
      positivity and TILs among women (P = .49). Interaction between brisk TILs and sex
      on SLN positivity was significant (P = .029). Among men, presence of brisk TILs
      was associated with prolonged OS (P = .038) but not after adjustment for SLN
      status (P = .42). There was no association between TIL status and OS among women.
      LIMITATIONS: Findings from this single-institution study have yet to be validated
      by other research groups. CONCLUSIONS: The implications of TILs in predicting SLN
      positivity appear to be more relevant for men than for women.
CI  - Copyright (c) 2018 American Academy of Dermatology, Inc. Published by Elsevier
      Inc. All rights reserved.
FAU - Sinnamon, Andrew J
AU  - Sinnamon AJ
AD  - Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, 
      Pennsylvania; Department of Biostatistics, Epidemiology and Informatics,
      University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
      andrew.sinnamon@uphs.upenn.edu.
FAU - Sharon, Cimarron E
AU  - Sharon CE
AD  - Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Song, Yun
AU  - Song Y
AD  - Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Neuwirth, Madalyn G
AU  - Neuwirth MG
AD  - Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Elder, David E
AU  - Elder DE
AD  - Department of Pathology, Hospital of the University of Pennsylvania,
      Philadelphia, Pennsylvania.
FAU - Xu, Xiaowei
AU  - Xu X
AD  - Department of Pathology, Hospital of the University of Pennsylvania,
      Philadelphia, Pennsylvania.
FAU - Chu, Emily Y
AU  - Chu EY
AD  - Department of Dermatology, Hospital of the University of Pennsylvania,
      Philadelphia, Pennsylvania.
FAU - Ming, Michael E
AU  - Ming ME
AD  - Department of Dermatology, Hospital of the University of Pennsylvania,
      Philadelphia, Pennsylvania.
FAU - Fraker, Douglas L
AU  - Fraker DL
AD  - Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
FAU - Gimotty, Phyllis A
AU  - Gimotty PA
AD  - Department of Biostatistics, Epidemiology and Informatics, University of
      Pennsylvania, Philadelphia, Pennsylvania.
FAU - Karakousis, Giorgos C
AU  - Karakousis GC
AD  - Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, 
      Pennsylvania.
LA  - eng
PT  - Journal Article
DEP - 20180305
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - Melanoma, Cutaneous Malignant
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Lymphocytes, Tumor-Infiltrating/*immunology
MH  - Male
MH  - Melanoma/*immunology/mortality/pathology
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Sentinel Lymph Node Biopsy
MH  - Sex Factors
MH  - Skin Neoplasms/*immunology/mortality/pathology
OTO - NOTNLM
OT  - immune response
OT  - melanoma
OT  - prognosis
OT  - sentinel lymph node
OT  - sex
OT  - tumor-infiltrating lymphocytes
EDAT- 2018/03/09 06:00
MHDA- 2018/12/27 06:00
CRDT- 2018/03/09 06:00
PHST- 2017/10/13 00:00 [received]
PHST- 2018/02/12 00:00 [revised]
PHST- 2018/02/23 00:00 [accepted]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2018/12/27 06:00 [medline]
PHST- 2018/03/09 06:00 [entrez]
AID - S0190-9622(18)30352-9 [pii]
AID - 10.1016/j.jaad.2018.02.066 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2018 Aug;79(2):245-251. doi: 10.1016/j.jaad.2018.02.066. Epub
      2018 Mar 5.