PMID- 29492969
OWN - NLM
STAT- MEDLINE
DCOM- 20190123
LR  - 20190329
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 143
IP  - 4
DP  - 2018 Aug 15
TI  - Etiology of hormone receptor positive breast cancer differs by levels of
      histologic grade and proliferation.
PG  - 746-757
LID - 10.1002/ijc.31352 [doi]
AB  - Limited epidemiological evidence suggests that the etiology of hormone receptor
      positive (HR+) breast cancer may differ by levels of histologic grade and
      proliferation. We pooled risk factor and pathology data on 5,905 HR+ breast
      cancer cases and 26,281 controls from 11 epidemiological studies. Proliferation
      was determined by centralized automated measures of KI67 in tissue microarrays.
      Odds ratios (OR), 95% confidence intervals (CI) and p-values for case-case and
      case-control comparisons for risk factors in relation to levels of grade and
      quartiles (Q1-Q4) of KI67 were estimated using polytomous logistic regression
      models. Case-case comparisons showed associations between nulliparity and high
      KI67 [OR (95% CI) for Q4 vs. Q1 = 1.54 (1.22, 1.95)]; obesity and high grade
      [grade 3 vs. 1 = 1.68 (1.31, 2.16)] and current use of combined hormone therapy
      (HT) and low grade [grade 3 vs. 1 = 0.27 (0.16, 0.44)] tumors. In case-control
      comparisons, nulliparity was associated with elevated risk of tumors with high
      but not low levels of proliferation [1.43 (1.14, 1.81) for KI67 Q4 vs. 0.83
      (0.60, 1.14) for KI67 Q1]; obesity among women >/=50 years with high but not low 
      grade tumors [1.55 (1.17, 2.06) for grade 3 vs. 0.88 (0.66, 1.16) for grade 1]
      and HT with low but not high grade tumors [3.07 (2.22, 4.23) for grade 1 vs. 0.85
      (0.55, 1.30) for grade 3]. Menarcheal age and family history were similarly
      associated with HR+ tumors of different grade or KI67 levels. These findings
      provide insights into the etiologic heterogeneity of HR+ tumors.
CI  - (c) 2018 The Authors International Journal of Cancer published by John Wiley &
      Sons Ltd on behalf of UICC.
FAU - Abubakar, Mustapha
AU  - Abubakar M
AUID- ORCID: 0000-0003-3728-6535
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National
      Institutes of Health, Rockville, MD.
AD  - Division of Genetics and Epidemiology, The Institute of Cancer Research, London, 
      United Kingdom.
FAU - Chang-Claude, Jenny
AU  - Chang-Claude J
AD  - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ),
      Heidelberg, Germany.
AD  - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf,
      Hamburg, Germany.
FAU - Ali, H Raza
AU  - Ali HR
AD  - Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge,
      United Kingdom.
FAU - Chatterjee, Nilanjan
AU  - Chatterjee N
AD  - Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins
      University, Baltimore, MD.
AD  - Department of Oncology, School of Medicine, Sidney Kimmel Comprehensive Cancer
      Center, Johns Hopkins University, Baltimore, MD.
FAU - Coulson, Penny
AU  - Coulson P
AD  - Division of Genetics and Epidemiology, The Institute of Cancer Research, London, 
      United Kingdom.
FAU - Daley, Frances
AU  - Daley F
AD  - Division of Breast Cancer Research, Breast Cancer Now Toby Robins Research
      Centre, The Institute of Cancer Research, London, United Kingdom.
FAU - Blows, Fiona
AU  - Blows F
AD  - Department of Oncology, Centre for Cancer Genetic Epidemiology, University of
      Cambridge, Cambridge, United Kingdom.
FAU - Benitez, Javier
AU  - Benitez J
AUID- ORCID: 0000-0002-0923-7202
AD  - Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer
      Research Centre (CNIO), Madrid, Spain.
AD  - Centro de Investigacion en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
FAU - Milne, Roger L
AU  - Milne RL
AD  - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
AD  - Melbourne School of Population and Global Health, Centre for Epidemiology and
      Biostatistics, The University of Melbourne, Melbourne, VIC, Australia.
FAU - Brenner, Hermann
AU  - Brenner H
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research
      Center (DKFZ), Heidelberg, Germany.
AD  - Division of Preventive Oncology, German Cancer Research Center (DKFZ), and
      National Center for Tumor Diseases (NCT), Heidelberg, Germany.
AD  - German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ),
      Heidelberg, Germany.
FAU - Stegmaier, Christa
AU  - Stegmaier C
AD  - Saarland Cancer Registry, Saarland, Germany.
FAU - Mannermaa, Arto
AU  - Mannermaa A
AD  - School of Medicine, Institute of Clinical Medicine, Pathology and Forensic
      Medicine, Cancer Center of Eastern Finland, University of Eastern Finland,
      Kuopio, Finland.
AD  - Department of Clinical Pathology, Imaging Center, Kuopio University Hospital,
      Kuopio, Finland.
FAU - Rudolph, Anja
AU  - Rudolph A
AD  - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ),
      Heidelberg, Germany.
FAU - Sinn, Peter
AU  - Sinn P
AD  - Department of Pathology, Institute of Pathology, Heidelberg University Hospital, 
      Heidelberg, Germany.
FAU - Couch, Fergus J
AU  - Couch FJ
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
FAU - Devilee, Peter
AU  - Devilee P
AD  - Department of Human Genetics & Department of Pathology, Leiden University Medical
      Center, Leiden, The Netherlands.
FAU - Tollenaar, Rob A E M
AU  - Tollenaar RAEM
AD  - Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
FAU - Seynaeve, Caroline
AU  - Seynaeve C
AD  - Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer
      Institute, Rotterdam, The Netherlands.
FAU - Figueroa, Jonine
AU  - Figueroa J
AD  - Usher Institute of Population Health Sciences and Informatics, The University of 
      Edinburgh, Scotland, United Kingdom.
FAU - Lissowska, Jolanta
AU  - Lissowska J
AD  - Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial
      Cancer Center and Institute of Oncology, Warsaw, Poland.
FAU - Hewitt, Stephen
AU  - Hewitt S
AD  - Laboratory of Pathology, National Cancer Institute, National Institutes of
      Health, Rockville, MD.
FAU - Hooning, Maartje J
AU  - Hooning MJ
AD  - Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer
      Institute, Rotterdam, The Netherlands.
FAU - Hollestelle, Antoinette
AU  - Hollestelle A
AD  - Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer
      Institute, Rotterdam, The Netherlands.
FAU - Foekens, Renee
AU  - Foekens R
AD  - Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer
      Institute, Rotterdam, The Netherlands.
FAU - Koppert, Linetta B
AU  - Koppert LB
AD  - Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The
      Netherlands.
FAU - Investigators, kConFab
AU  - Investigators K
AD  - Research Department, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
AD  - The Sir Peter MacCallum Department of Oncology University of Melbourne,
      Parkville, Melbourne, VIC, Australia.
FAU - Bolla, Manjeet K
AU  - Bolla MK
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic
      Epidemiology, University of Cambridge, Cambridge, United Kingdom.
FAU - Wang, Qin
AU  - Wang Q
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic
      Epidemiology, University of Cambridge, Cambridge, United Kingdom.
FAU - Jones, Michael E
AU  - Jones ME
AD  - Division of Genetics and Epidemiology, The Institute of Cancer Research, London, 
      United Kingdom.
FAU - Schoemaker, Minouk J
AU  - Schoemaker MJ
AD  - Division of Genetics and Epidemiology, The Institute of Cancer Research, London, 
      United Kingdom.
FAU - Keeman, Renske
AU  - Keeman R
AD  - Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van
      Leeuwenhoek Hospital, Amsterdam, The Netherlands.
FAU - Easton, Douglas F
AU  - Easton DF
AD  - Department of Oncology, Centre for Cancer Genetic Epidemiology, University of
      Cambridge, Cambridge, United Kingdom.
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic
      Epidemiology, University of Cambridge, Cambridge, United Kingdom.
FAU - Swerdlow, Anthony J
AU  - Swerdlow AJ
AD  - Division of Genetics and Epidemiology, The Institute of Cancer Research, London, 
      United Kingdom.
AD  - Division of Breast Cancer Research, The Institute of Cancer Research, London,
      United Kingdom.
FAU - Sherman, Mark E
AU  - Sherman ME
AD  - Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic,
      Jacksonville, FL.
FAU - Schmidt, Marjanka K
AU  - Schmidt MK
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic
      Epidemiology, University of Cambridge, Cambridge, United Kingdom.
AD  - Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute,
      Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
FAU - Pharoah, Paul D
AU  - Pharoah PD
AD  - Department of Oncology, Centre for Cancer Genetic Epidemiology, University of
      Cambridge, Cambridge, United Kingdom.
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic
      Epidemiology, University of Cambridge, Cambridge, United Kingdom.
FAU - Garcia-Closas, Montserrat
AU  - Garcia-Closas M
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National
      Institutes of Health, Rockville, MD.
LA  - eng
GR  - 10119/Cancer Research UK/United Kingdom
GR  - P50 CA116201/CA/NCI NIH HHS/United States
GR  - Z99 CA999999/NULL/Intramural NIH HHS/United States
GR  - Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180325
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Contraceptives, Oral, Hormonal)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (MKI67 protein, human)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/metabolism
MH  - Body Mass Index
MH  - Breast Neoplasms/*etiology/metabolism/*pathology
MH  - Case-Control Studies
MH  - *Cell Proliferation
MH  - Contraceptives, Oral, Hormonal
MH  - Female
MH  - Humans
MH  - Ki-67 Antigen/metabolism
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Obesity/complications
MH  - Parity
MH  - Receptors, Estrogen/*metabolism
MH  - Receptors, Progesterone/*metabolism
MH  - Risk Factors
PMC - PMC6041155
MID - NIHMS951040
OTO - NOTNLM
OT  - *KI67
OT  - *breast cancer
OT  - *epidemiology
OT  - *grade
OT  - *hormone therapy
OT  - *nulliparity
OT  - *obesity
OT  - *proliferation
EDAT- 2018/03/02 06:00
MHDA- 2019/01/24 06:00
CRDT- 2018/03/02 06:00
PHST- 2017/11/03 00:00 [received]
PHST- 2018/01/24 00:00 [revised]
PHST- 2018/01/26 00:00 [accepted]
PHST- 2018/03/02 06:00 [pubmed]
PHST- 2019/01/24 06:00 [medline]
PHST- 2018/03/02 06:00 [entrez]
AID - 10.1002/ijc.31352 [doi]
PST - ppublish
SO  - Int J Cancer. 2018 Aug 15;143(4):746-757. doi: 10.1002/ijc.31352. Epub 2018 Mar
      25.