PMID- 29436399
OWN - NLM
STAT- In-Data-Review
LR  - 20181023
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 102
IP  - 11
DP  - 2018 Nov
TI  - Type 2 choroidal neovascularisation in polypoidal choroidal vasculopathy: a
      retrospective case series.
PG  - 1570-1574
LID - 10.1136/bjophthalmol-2017-311518 [doi]
AB  - BACKGROUND AND OBJECTIVE: To demonstrate the coexistence of polypoidal choroidal 
      vasculopathy (PCV) with type 2 neovascularisation (NV), we used multimodal
      imaging, including spectral-domain optical coherence tomography angiography
      (SD-OCTA), to identify both types of lesions in the same eye. STUDY DESIGN: This 
      retrospective case series reviewed patients with PCV diagnosed with indocyanine
      green angiography (ICGA), fluorescein angiography (FA), SD-OCT and SD-OCTA.
      RESULTS: 15 eyes of 14 patients were imaged and diagnosed with PCV by ICGA. ICGA 
      identified polyps in all these eyes, while SD-OCTA imaging identified polypoidal 
      lesions in only 11 (73%) of these eyes with PCV. Branching vascular networks
      (BVNs) were detected in 12 eyes (80%) by ICGA and SD-OCTA. Type 2 NV was detected
      in four eyes (27%) by FA and SD-OCTA. In these eyes, a combination of polyps,
      BVNs and type 2 NV were detected using FA, ICGA and SD-OCTA. CONCLUSION: BVN and 
      type 2 NV can coexist in the same PCV eye and communicate with each other. This
      suggests that polyps may represent a structural variant of neovascular tissue
      rather than a distinct pathogenic process in NV.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text
      of the article) 2018. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Liang, Shuting
AU  - Liang S
AUID- ORCID: http://orcid.org/0000-0002-2485-0742
AD  - Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
AD  - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, 
      Beijing, China.
AD  - Collage of Optometry, Peking University health Science Center, Beijing, China.
FAU - Shi, Xuan
AU  - Shi X
AD  - Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
AD  - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, 
      Beijing, China.
AD  - Collage of Optometry, Peking University health Science Center, Beijing, China.
FAU - Rosenfeld, Philip J
AU  - Rosenfeld PJ
AD  - Bascom Palmer Eye Institute, University of Miami Miller School of Medicine,
      Miami, Florida, USA.
FAU - Li, Xiaoxin
AU  - Li X
AD  - Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
AD  - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20180207
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
OTO - NOTNLM
OT  - Optical Coherence Tomography Angiography (OCTA)
OT  - Polypoidal Choroidal Vasculopathy (PCV)
OT  - neovascular Age-related Macular Degeneration (nAMD)
COIS- Competing interests: PJR receives research support and consulting fees from Carl 
      Zeiss Meditec, Dublin, California, USA.
EDAT- 2018/02/14 06:00
MHDA- 2018/02/14 06:00
CRDT- 2018/02/14 06:00
PHST- 2017/10/26 00:00 [received]
PHST- 2018/01/04 00:00 [revised]
PHST- 2018/01/14 00:00 [accepted]
PHST- 2018/02/14 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
PHST- 2018/02/14 06:00 [entrez]
AID - bjophthalmol-2017-311518 [pii]
AID - 10.1136/bjophthalmol-2017-311518 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2018 Nov;102(11):1570-1574. doi:
      10.1136/bjophthalmol-2017-311518. Epub 2018 Feb 7.