PMID- 29428473
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20180606
IS  - 1532-2157 (Electronic)
IS  - 0748-7983 (Linking)
VI  - 44
IP  - 4
DP  - 2018 Apr
TI  - Urinary dysfunction after rectal cancer surgery: Results from a randomized trial 
      comparing mesorectal excision with and without lateral lymph node dissection for 
      clinical stage II or III lower rectal cancer (Japan Clinical Oncology Group
      Study, JCOG0212).
PG  - 463-468
LID - S0748-7983(18)30045-3 [pii]
LID - 10.1016/j.ejso.2018.01.015 [doi]
AB  - BACKGROUND: Postoperative urinary dysfunction is a major complication of rectal
      cancer surgery. A randomized controlled trial (JCOG0212) concluded that the
      noninferiority of mesorectal excision alone to mesorectal excision with lateral
      lymph node dissection was not confirmed in terms of relapse-free survival.
      METHODS: Eligibility criteria included histologically proven clinical stage
      II/III rectal cancer, a main lesion located in the rectum with the lower margin
      below the peritoneal reflection, and the absence of lateral lymph node
      enlargement. After confirming R0 resection by mesorectal excision, patients were 
      randomized intraoperatively. The residual urine volume was measured three times. 
      Urinary dysfunction was defined as >/=50 mL residual urine occurring at least
      once or no measurement of residual urinary volume. This trial was registered with
      the UMIN Clinical Trials Registry, number C000000034. RESULTS: In the mesorectal 
      excision alone and the mesorectal excision with lateral lymph node dissection
      groups, the incidence of early urinary dysfunction were 58% and 59%,
      respectively. A tumor location in the lower rectum (vs. upper rectum) and a blood
      loss of >/=500 mL (vs. <500 mL) were associated with an increased risk of early
      urinary dysfunction. However, only blood loss was independently predictive of
      early urinary dysfunction (relative risk, 1.25 [95% CI: 1.10-1.55], p = .04).
      CONCLUSIONS: Mesorectal excision with lateral lymph node dissection is not
      associated with a significant increase in the incidence of urinary dysfunction.
      Urinary dysfunction is associated with tumor location and blood loss.
CI  - Copyright (c) 2018. Published by Elsevier Ltd.
FAU - Ito, Masaaki
AU  - Ito M
AD  - Department of Colorectal Surgery, National Cancer Center Hospital East, Kashiwa, 
      Japan. Electronic address: maito@east.ncc.go.jp.
FAU - Kobayashi, Akihiro
AU  - Kobayashi A
AD  - Department of Colorectal Surgery, National Cancer Center Hospital East, Kashiwa, 
      Japan.
FAU - Fujita, Shin
AU  - Fujita S
AD  - Department of Surgery, Tochigi Cancer Center, Utsunomiya, Japan. Electronic
      address: sifujita@tcc.pref.tochigi.lg.jp.
FAU - Mizusawa, Junki
AU  - Mizusawa J
AD  - JCOG Data Center, National Cancer Center Hospital, Tokyo, Japan.
FAU - Kanemitsu, Yukihide
AU  - Kanemitsu Y
AD  - Colorectal Surgery Division, National Cancer Center Hospital Tokyo, Japan.
FAU - Kinugasa, Yusuke
AU  - Kinugasa Y
AD  - Department of Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
FAU - Komori, Koji
AU  - Komori K
AD  - Department of Surgery, Aichi Cancer Center, Nagoya, Japan.
FAU - Ohue, Masayuki
AU  - Ohue M
AD  - Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular
      Diseases, Osaka, Japan.
FAU - Ota, Mitsuyoshi
AU  - Ota M
AD  - Department of Surgery, Yokohama City University Medical Center Yokohama, Japan.
FAU - Akazai, Yoshihiro
AU  - Akazai Y
AD  - Department of Surgery, Okayama Saiseikai General Hospital, Okayama, Japan.
FAU - Shiozawa, Manabu
AU  - Shiozawa M
AD  - Department of Surgery, Kanagawa Cancer Center, Yokohama, Japan.
FAU - Yamaguchi, Takashi
AU  - Yamaguchi T
AD  - Department of Surgery, Kyoto Medical Center, Kyoto, Japan.
FAU - Akasu, Takayuki
AU  - Akasu T
AD  - Department of Surgery, The Imperial Household Agency Hospital, Tokyo, Japan.
FAU - Moriya, Yoshihiro
AU  - Moriya Y
AD  - Department of Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
CN  - Colorectal Cancer Study Group of Japan Clinical Oncology Group
LA  - eng
SI  - UMIN CTR/C000000034
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180117
PL  - England
TA  - Eur J Surg Oncol
JT  - European journal of surgical oncology : the journal of the European Society of
      Surgical Oncology and the British Association of Surgical Oncology
JID - 8504356
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Loss, Surgical/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Lymph Node Excision
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Operative Time
MH  - Postoperative Complications/*epidemiology
MH  - Rectal Neoplasms/*pathology/*surgery
MH  - Urination Disorders/*epidemiology
OTO - NOTNLM
OT  - *Autonomic nerve
OT  - *Lateral lymph node dissection
OT  - *Mesorectal excision
OT  - *Residual urine volume
OT  - *Urinary dysfunction
EDAT- 2018/02/13 06:00
MHDA- 2018/06/07 06:00
CRDT- 2018/02/12 06:00
PHST- 2017/11/17 00:00 [received]
PHST- 2018/01/09 00:00 [accepted]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
PHST- 2018/02/12 06:00 [entrez]
AID - S0748-7983(18)30045-3 [pii]
AID - 10.1016/j.ejso.2018.01.015 [doi]
PST - ppublish
SO  - Eur J Surg Oncol. 2018 Apr;44(4):463-468. doi: 10.1016/j.ejso.2018.01.015. Epub
      2018 Jan 17.