PMID- 29405297
OWN - NLM
STAT- MEDLINE
DCOM- 20190107
LR  - 20190107
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 143
IP  - 1
DP  - 2018 Jul 1
TI  - The influence of smoking, age and stage at diagnosis on the survival after
      larynx, hypopharynx and oral cavity cancers in Europe: The ARCAGE study.
PG  - 32-44
LID - 10.1002/ijc.31294 [doi]
AB  - Head and neck cancer (HNC) is a preventable malignancy that continues to cause
      substantial morbidity and mortality worldwide. Using data from the ARCAGE and
      Rome studies, we investigated the main predictors of survival after larynx,
      hypopharynx and oral cavity (OC) cancers. We used the Kaplan-Meier method to
      estimate overall survival, and Cox proportional models to examine the
      relationship between survival and sociodemographic and clinical characteristics. 
      604 larynx, 146 hypopharynx and 460 OC cancer cases were included in this study. 
      Over a median follow-up time of 4.6 years, nearly 50% (n = 586) of patients died.
      Five-year survival was 65% for larynx, 55% for OC and 35% for hypopharynx
      cancers. In a multivariable analysis, we observed an increased mortality risk
      among older (>/=71 years) versus younger (</=50 years) patients with
      larynx/hypopharynx combined (LH) and OC cancers [HR = 1.61, 95% CI 1.09-2.38 (LH)
      and HR = 2.12, 95% CI 1.35-3.33 (OC)], current versus never smokers [HR = 2.67,
      95% CI 1.40-5.08 (LH) and HR = 2.16, 95% CI 1.32-3.54 (OC)] and advanced versus
      early stage disease at diagnosis [IV versus I, HR = 2.60, 95% CI 1.78-3.79 (LH)
      and HR = 3.17, 95% CI 2.05-4.89 (OC)]. Survival was not associated with sex,
      alcohol consumption, education, oral health, p16 expression, presence of HPV
      infection or body mass index 2 years before cancer diagnosis. Despite advances in
      diagnosis and therapeutic modalities, survival after HNC remains low in Europe.
      In addition to the recognized prognostic effect of stage at diagnosis, smoking
      history and older age at diagnosis are important prognostic indicators for HNC.
CI  - (c) 2018 International Agency for Research on Cancer (IARC/WHO); licensed by
      UICC.
FAU - Abrahao, Renata
AU  - Abrahao R
AUID- ORCID: 0000-0002-1644-0313
AD  - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon,
      France.
FAU - Anantharaman, Devasena
AU  - Anantharaman D
AD  - Cancer Research Program, Rajiv Gandhi Centre for Biotechnology,
      Thiruvananthapuram, Kerala, India.
FAU - Gaborieau, Valerie
AU  - Gaborieau V
AD  - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon,
      France.
FAU - Abedi-Ardekani, Behnoush
AU  - Abedi-Ardekani B
AD  - Genetic Cancer Susceptibility Group, International Agency for Research on Cancer,
      Lyon, France.
FAU - Lagiou, Pagona
AU  - Lagiou P
AD  - Department of Hygiene, Epidemiology and Medical Statistics, University of Athens 
      Medical School, Athens, Greece.
FAU - Lagiou, Areti
AU  - Lagiou A
AD  - Department of Public Health and Community Health, School of Health Professions,
      Athens University of Applied Sciences, Athens, Greece.
FAU - Ahrens, Wolfgang
AU  - Ahrens W
AD  - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen,
      Germany.
AD  - Institute of Statistics, Faculty of Mathematics and Computer Science, University 
      Bremen, Bremen, Germany.
FAU - Holcatova, Ivana
AU  - Holcatova I
AD  - Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles
      University of Prague, Prage, Czech Republic.
FAU - Betka, Jaroslav
AU  - Betka J
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of
      Medicine, Charles University of Prague, Prague, Czech Republic.
FAU - Merletti, Franco
AU  - Merletti F
AD  - Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin,
      Turin, Italy.
FAU - Richiardi, Lorenzo
AU  - Richiardi L
AD  - Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin,
      Turin, Italy.
FAU - Kjaerheim, Kristina
AU  - Kjaerheim K
AD  - Cancer Registry of Norway, Oslo, Norway.
FAU - Serraino, Diego
AU  - Serraino D
AD  - Unit of Cancer Epidemiology, Aviano National Cancer Institute, IRCCS, Aviano,
      Italy.
FAU - Polesel, Jerry
AU  - Polesel J
AD  - Unit of Cancer Epidemiology, Aviano National Cancer Institute, IRCCS, Aviano,
      Italy.
FAU - Simonato, Lorenzo
AU  - Simonato L
AD  - Department of Cardiovascular and Thoracic Sciences, University of Padova, Padova,
      Italy.
FAU - Alemany, Laia
AU  - Alemany L
AD  - Institut Catala d'Oncologia, IDIBELL, L'Hospitalet de Llobregat, Catalonia,
      Spain.
AD  - CIBER en Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
FAU - Agudo Trigueros, Antonio
AU  - Agudo Trigueros A
AD  - Institut Catala d'Oncologia, IDIBELL, L'Hospitalet de Llobregat, Catalonia,
      Spain.
FAU - Macfarlane, Tatiana V
AU  - Macfarlane TV
AD  - Epidemiology Group, University of Aberdeen, Aberdeen, United Kingdom.
AD  - Ninewells Hospital and Medical School, University of Dundee, Dundee, United
      Kingdom.
FAU - Macfarlane, Gary J
AU  - Macfarlane GJ
AD  - Epidemiology Group, University of Aberdeen, Aberdeen, United Kingdom.
FAU - Znaor, Ariana
AU  - Znaor A
AUID- ORCID: 0000-0002-5849-4782
AD  - Cancer Surveillance Section, International Agency for Research on Cancer, Lyon,
      France.
FAU - Robinson, Max
AU  - Robinson M
AD  - Center for Oral Health Research, Newcastle University, Newcastle-upon-Tyne,
      United Kingdom.
FAU - Canova, Cristina
AU  - Canova C
AD  - Department of Cardiac, Thoracic and Vascular Sciences, University of Padova,
      Padova, Italy.
FAU - Conway, David I
AU  - Conway DI
AD  - School of Medicine, Dentistry, and Nursing, University of Glasgow, Glasgow,
      United Kingdom.
FAU - Wright, Sylvia
AU  - Wright S
AD  - Department of Pathology, Queen Elizabeth University Hospital, Glasgow, United
      Kingdom.
FAU - Healy, Claire M
AU  - Healy CM
AD  - Trinity College School of Dental Science, Dublin, Ireland.
FAU - Toner, Mary
AU  - Toner M
AD  - Trinity College School of Dental Science, Dublin, Ireland.
FAU - Cadoni, Gabriella
AU  - Cadoni G
AD  - Institute of Othorinolaringoiatry, Universita Cattolica del Sacro Cuore,
      Fondazione Policlinico 'Agostino Gemelli', Rome, Italy.
FAU - Boccia, Stefania
AU  - Boccia S
AD  - Section of Hygiene - Institute of Public Health, Universita Cattolica del Sacro
      Cuore, Fondazione Policlinico 'Agostino Gemelli', Rome, Italy.
FAU - Gheit, Tarik
AU  - Gheit T
AD  - Infections and Cancer Biology Group, International Agency for Research on Cancer,
      Lyon, France.
FAU - Tommasino, Massimo
AU  - Tommasino M
AD  - Infections and Cancer Biology Group, International Agency for Research on Cancer,
      Lyon, France.
FAU - Scelo, Ghislaine
AU  - Scelo G
AUID- ORCID: 0000-0002-2692-8507
AD  - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon,
      France.
FAU - Brennan, Paul
AU  - Brennan P
AUID- ORCID: 0000-0002-0518-8714
AD  - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon,
      France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180223
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Europe/epidemiology
MH  - Female
MH  - Humans
MH  - Hypopharyngeal Neoplasms/*mortality/pathology
MH  - Laryngeal Neoplasms/*mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*mortality/pathology
MH  - Neoplasm Staging
MH  - Regression Analysis
MH  - Smoking/adverse effects/*epidemiology
MH  - Survival Analysis
OTO - NOTNLM
OT  - *ARCAGE study
OT  - *head and neck cancer
OT  - *predictors of survival
EDAT- 2018/02/07 06:00
MHDA- 2019/01/08 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/09/27 00:00 [received]
PHST- 2018/01/19 00:00 [revised]
PHST- 2018/01/23 00:00 [accepted]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2019/01/08 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
AID - 10.1002/ijc.31294 [doi]
PST - ppublish
SO  - Int J Cancer. 2018 Jul 1;143(1):32-44. doi: 10.1002/ijc.31294. Epub 2018 Feb 23.