PMID- 29359390
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20190314
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 91
IP  - S1
DP  - 2018 Feb 15
TI  - Dual antiplatelet therapy after coronary drug-eluting stent implantation in
      China: A large single center study.
PG  - 566-572
LID - 10.1002/ccd.27500 [doi]
AB  - OBJECTIVE: To investigate the actual dual antiplatelet therapy (DAPT) duration
      after drug-eluting stent (DES) treatment in China. BACKGROUND: Currently, less is
      known about actual DAPT duration after drug-eluting stent (DES) treatment in
      China. Here, we performed a study in the largest cardiovascular center in China
      to investigate DAPT duration and identify associated factors after DES
      implantation. METHODS: A total of 9,919 consecutive patients with DES
      implantation from January 2013 to December 2013 were enrolled. DAPT cessation was
      observed, and factors associated with different DAPT durations were analyzed.
      RESULTS: The median follow-up time was 882 days. The proportion of patients with 
      DAPT coverage at 1-year of follow-up was 97.3%, and it decreased to 30.1% for 2
      years. The distribution of DAPT duration was not significantly different among
      patients with acute myocardial infarction (AMI) versus non-AMI (P = 0.41) and
      with new-generation DES versus first-generation DES (P = 0.54). The multivariable
      analysis indicated some independent predictors prolonging DAPT duration,
      including target vessel revascularization (OR 2.50, 95% CI 2.04-3.06, P < 0.001),
      stent numbers (OR 1.10, 95% CI 1.05-1.15, P < 0.001), and previous coronary
      artery bypass grafting (OR 0.76, 95% CI 0.61-0.96, P = 0.02). Other clinical
      factors, such as the increased risk of bleeding and high ischemic risk, were not 
      associated with DAPT duration. CONCLUSIONS: The 1-year DAPT after DES was applied
      to 97.3% of Chinese patients in the studied clinical center. However, the DAPT
      duration after 1 year was not adjusted according to the patients' bleeding
      situation and ischemic risks.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Xu, Jing-Jing
AU  - Xu JJ
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular
      Diseases, Chinese Academy of Medical Science and Peking Union Medical College,
      Beijing, China.
FAU - Gao, Zhan
AU  - Gao Z
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular
      Diseases, Chinese Academy of Medical Science and Peking Union Medical College,
      Beijing, China.
FAU - Zhang, Yin
AU  - Zhang Y
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular
      Diseases, Chinese Academy of Medical Science and Peking Union Medical College,
      Beijing, China.
FAU - Gao, Li-Jian
AU  - Gao LJ
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular
      Diseases, Chinese Academy of Medical Science and Peking Union Medical College,
      Beijing, China.
FAU - Chen, Jue
AU  - Chen J
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular
      Diseases, Chinese Academy of Medical Science and Peking Union Medical College,
      Beijing, China.
FAU - Qiao, Shu-Bin
AU  - Qiao SB
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular
      Diseases, Chinese Academy of Medical Science and Peking Union Medical College,
      Beijing, China.
FAU - Gao, Run-Lin
AU  - Gao RL
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular
      Diseases, Chinese Academy of Medical Science and Peking Union Medical College,
      Beijing, China.
FAU - Yang, Yue-Jin
AU  - Yang YJ
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular
      Diseases, Chinese Academy of Medical Science and Peking Union Medical College,
      Beijing, China.
FAU - Xu, Bo
AU  - Xu B
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular
      Diseases, Chinese Academy of Medical Science and Peking Union Medical College,
      Beijing, China.
FAU - Yuan, Jin-Qing
AU  - Yuan JQ
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular
      Diseases, Chinese Academy of Medical Science and Peking Union Medical College,
      Beijing, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180123
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the
      Society for Cardiac Angiography & Interventions
JID - 100884139
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Acute Coronary Syndrome/blood/diagnosis/*surgery
MH  - Aged
MH  - China
MH  - Coronary Artery Disease/blood/diagnosis/*surgery
MH  - Drug Administration Schedule
MH  - Drug Therapy, Combination
MH  - *Drug-Eluting Stents
MH  - Female
MH  - Hemorrhage/chemically induced
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/diagnosis/*surgery
MH  - Percutaneous Coronary Intervention/adverse effects/*instrumentation
MH  - Platelet Aggregation Inhibitors/*administration & dosage/adverse effects
MH  - Prospective Studies
MH  - Prosthesis Design
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - *drug-eluting stent
OT  - *dual antiplatelet therapy
OT  - *percutaneous coronary intervention
EDAT- 2018/01/24 06:00
MHDA- 2019/03/15 06:00
CRDT- 2018/01/24 06:00
PHST- 2017/11/30 00:00 [received]
PHST- 2017/12/27 00:00 [accepted]
PHST- 2018/01/24 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
PHST- 2018/01/24 06:00 [entrez]
AID - 10.1002/ccd.27500 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2018 Feb 15;91(S1):566-572. doi: 10.1002/ccd.27500.
      Epub 2018 Jan 23.