PMID- 29341151
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1365-2168 (Electronic)
IS  - 0007-1323 (Linking)
VI  - 105
IP  - 2
DP  - 2018 Jan
TI  - Gut microbiome influences on anastomotic leak and recurrence rates following
      colorectal cancer surgery.
PG  - e131-e141
LID - 10.1002/bjs.10760 [doi]
AB  - BACKGROUND: The pathogenesis of colorectal cancer recurrence after a curative
      resection remains poorly understood. A yet-to-be accounted for variable is the
      composition and function of the microbiome adjacent to the tumour and its
      influence on the margins of resection following surgery. METHODS: PubMed was
      searched for historical as well as current manuscripts dated between 1970 and
      2017 using the following keywords: 'colorectal cancer recurrence', 'microbiome', 
      'anastomotic leak', 'anastomotic failure' and 'mechanical bowel preparation'.
      RESULTS: There is a substantial and growing body of literature to demonstrate the
      various mechanisms by which environmental factors act on the microbiome to alter 
      its composition and function with the net result of adversely affecting
      oncological outcomes following surgery. Some of these environmental factors
      include diet, antibiotic use, the methods used to prepare the colon for surgery
      and the physiological stress of the operation itself. CONCLUSION: Interrogating
      the intestinal microbiome using next-generation sequencing technology has the
      potential to influence cancer outcomes following colonic resection.
CI  - (c) 2018 BJS Society Ltd Published by John Wiley & Sons Ltd.
FAU - Gaines, S
AU  - Gaines S
AUID- ORCID: 0000-0002-9072-0233
AD  - Department of Surgery, Pritzker School of Medicine, University of Chicago, 5841
      South Maryland Avenue, MC 6090 Chicago, Illinois 60025, USA.
FAU - Shao, C
AU  - Shao C
AD  - Department of Surgery, Pritzker School of Medicine, University of Chicago, 5841
      South Maryland Avenue, MC 6090 Chicago, Illinois 60025, USA.
FAU - Hyman, N
AU  - Hyman N
AD  - Department of Surgery, Pritzker School of Medicine, University of Chicago, 5841
      South Maryland Avenue, MC 6090 Chicago, Illinois 60025, USA.
FAU - Alverdy, J C
AU  - Alverdy JC
AD  - Department of Surgery, Pritzker School of Medicine, University of Chicago, 5841
      South Maryland Avenue, MC 6090 Chicago, Illinois 60025, USA.
LA  - eng
GR  - F32 CA228235/CA/NCI NIH HHS/United States
GR  - P30 DK042086/DK/NIDDK NIH HHS/United States
GR  - R01 GM062344/GM/NIGMS NIH HHS/United States
GR  - T32 DK007074/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Br J Surg
JT  - The British journal of surgery
JID - 0372553
SB  - AIM
SB  - IM
MH  - Anastomosis, Surgical/adverse effects
MH  - Anastomotic Leak/etiology/*microbiology
MH  - Colorectal Neoplasms/*surgery
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - Neoplasm Recurrence, Local/etiology/*microbiology
MH  - Preoperative Care/adverse effects/methods
PMC - PMC5903685
MID - NIHMS957932
EDAT- 2018/01/18 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/01/18 06:00
PHST- 2017/08/03 00:00 [received]
PHST- 2017/10/10 00:00 [revised]
PHST- 2017/10/19 00:00 [accepted]
PHST- 2018/01/18 06:00 [entrez]
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
AID - 10.1002/bjs.10760 [doi]
PST - ppublish
SO  - Br J Surg. 2018 Jan;105(2):e131-e141. doi: 10.1002/bjs.10760.