PMID- 29326112
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20190114
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 104
IP  - 12
DP  - 2018 Jun
TI  - Epidemiology of new-onset atrial fibrillation following coronary artery bypass
      graft surgery.
PG  - 985-992
LID - 10.1136/heartjnl-2017-312150 [doi]
AB  - OBJECTIVES: Postoperative atrial fibrillation (AF) following coronary artery
      bypass graft surgery (CABG) is significantly associated with reduced survival,
      but poor characterisation and inconsistent definitions present barriers to
      developing effective prophylaxis and management. We sought to address this
      knowledge gap. METHODS: From 2002 to 2010, 11 239 consecutive patients without AF
      underwent isolated CABG at five sites. Clinical data collected for the Society of
      Thoracic Surgeons (STS) Database were augmented with details on AF detected via
      continuous in-hospital ECG/telemetry monitoring to assess new-onset post-CABG AF 
      (adjusted for STS risk of mortality); time to first AF; durations of first and
      longest AF episodes; total in-hospital time in AF; number of in-hospital AF
      episodes; operative mortality; stroke; discharge in AF; and length of stay (LOS).
      RESULTS: Unadjusted incidence of new-onset post-CABG AF was 29.5%. Risk-adjusted 
      incidence was 33.1% and varied little over time (P=0.139). Among 3312 patients
      with post-CABG AF, adjusted median time to first AF was 52 (IQR: 48-55) hours;
      mean (SD) duration of first and longest events were 7.2 (5.3,9.1) and 13.1
      (10.4,15.9) hours, respectively, and adjusted median total time in AF was 22
      (IQR: 18-26) hours. Adjusted rates of operative mortality, stroke and discharge
      in AF did not vary significantly over time (P=0.156, P=0.965 and P=0.347,
      respectively). LOS varied (P=0.035), but in no discernible pattern. CONCLUSIONS: 
      Each year, ~800 000 people undergo CABG worldwide; >264 000 will develop
      post-CABG AF. Onset is typically 2-3 days post-CABG and episodes last, on
      average, several hours. Effective prophylaxis and management is urgently needed
      to reduce associated risks of adverse outcomes.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text
      of the article) 2018. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Filardo, Giovanni
AU  - Filardo G
AD  - Department of Epidemiology, Center for Clinical Effectiveness, Baylor Scott &
      White Health, Dallas, Texas, USA.
AD  - Robbins Institute for Health Policy and Leadership, Baylor University, Waco,
      Texas, USA.
FAU - Damiano, Ralph J Jr
AU  - Damiano RJ Jr
AD  - Department of Cardiac Surgery, Washington University School of Medicine and
      Barnes-Jewish Hospital, St Louis, Missouri, USA.
FAU - Ailawadi, Gorav
AU  - Ailawadi G
AD  - Division of Thoracic and Cardiovascular Surgery, University of Virginia,
      Charlottesville, Virginia, USA.
FAU - Thourani, Vinod H
AU  - Thourani VH
AD  - Division of Cardiothoracic Surgery, Emory University, Atlanta, Georgia, USA.
FAU - Pollock, Benjamin D
AU  - Pollock BD
AD  - Department of Epidemiology, Center for Clinical Effectiveness, Baylor Scott &
      White Health, Dallas, Texas, USA.
FAU - Sass, Danielle M
AU  - Sass DM
AD  - Department of Epidemiology, Center for Clinical Effectiveness, Baylor Scott &
      White Health, Dallas, Texas, USA.
FAU - Phan, Teresa K
AU  - Phan TK
AD  - Department of Epidemiology, Center for Clinical Effectiveness, Baylor Scott &
      White Health, Dallas, Texas, USA.
FAU - Nguyen, Hoa
AU  - Nguyen H
AD  - Department of Epidemiology, Center for Clinical Effectiveness, Baylor Scott &
      White Health, Dallas, Texas, USA.
FAU - da Graca, Briget
AU  - da Graca B
AD  - Robbins Institute for Health Policy and Leadership, Baylor University, Waco,
      Texas, USA.
AD  - Center for Clinical Effectiveness, Baylor Scott & White Health, Dallas, Texas,
      USA.
AD  - Center for Clinical Effectiveness, Office of the Chief Quality Officer, Baylor
      Scott & White Health, Dallas, Texas, USA.
LA  - eng
GR  - R01 HL103683/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180111
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - AIM
SB  - IM
CIN - Heart. 2018 Jun;104(12):964-965. PMID: 29352011
MH  - Aged
MH  - Atrial Fibrillation/diagnosis/*epidemiology/mortality/therapy
MH  - Coronary Artery Bypass/*adverse effects/mortality
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Incidence
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Patient Discharge
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - United States/epidemiology
OTO - NOTNLM
OT  - *atrial fibrillation
OT  - *coronary artery disease surgery
OT  - *epidemiology
COIS- Competing interests: None declared.
EDAT- 2018/01/13 06:00
MHDA- 2019/01/15 06:00
CRDT- 2018/01/13 06:00
PHST- 2017/07/12 00:00 [received]
PHST- 2017/11/30 00:00 [revised]
PHST- 2017/12/05 00:00 [accepted]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/01/13 06:00 [entrez]
AID - heartjnl-2017-312150 [pii]
AID - 10.1136/heartjnl-2017-312150 [doi]
PST - ppublish
SO  - Heart. 2018 Jun;104(12):985-992. doi: 10.1136/heartjnl-2017-312150. Epub 2018 Jan
      11.