PMID- 29317434
OWN - NLM
STAT- MEDLINE
DCOM- 20190318
LR  - 20190329
IS  - 1538-7445 (Electronic)
IS  - 0008-5472 (Linking)
VI  - 78
IP  - 7
DP  - 2018 Apr 1
TI  - Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI.
PG  - 1859-1872
LID - 10.1158/0008-5472.CAN-17-1546 [doi]
AB  - Several distinct fluid flow phenomena occur in solid tumors, including
      intravascular blood flow and interstitial convection. Interstitial fluid pressure
      is often raised in solid tumors, which can limit drug delivery. To probe
      low-velocity flow in tumors resulting from raised interstitial fluid pressure, we
      developed a novel MRI technique named convection-MRI, which uses a phase-contrast
      acquisition with a dual-inversion vascular nulling preparation to separate intra-
      and extravascular flow. Here, we report the results of experiments in flow
      phantoms, numerical simulations, and tumor xenograft models to investigate the
      technical feasibility of convection-MRI. We observed a significant correlation
      between estimates of effective fluid pressure from convection-MRI with
      gold-standard, invasive measurements of interstitial fluid pressure in mouse
      models of human colorectal carcinoma. Our results show how convection-MRI can
      provide insights into the growth and responsiveness to vascular-targeting therapy
      in colorectal cancers.Significance: A noninvasive method for measuring
      low-velocity fluid flow caused by raised fluid pressure can be used to assess
      changes caused by therapy. Cancer Res; 78(7); 1859-72. (c)2018 AACR.
CI  - (c)2018 American Association for Cancer Research.
FAU - Walker-Samuel, Simon
AU  - Walker-Samuel S
AD  - UCL Centre for Advanced Biomedical Imaging, Division of Medicine, London, UK.
      simon.walkersamuel@ucl.ac.uk.
FAU - Roberts, Thomas A
AU  - Roberts TA
AD  - UCL Centre for Advanced Biomedical Imaging, Division of Medicine, London, UK.
FAU - Ramasawmy, Rajiv
AU  - Ramasawmy R
AD  - UCL Centre for Advanced Biomedical Imaging, Division of Medicine, London, UK.
FAU - Burrell, Jake S
AU  - Burrell JS
AD  - Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton,
      Surrey, UK.
FAU - Johnson, Sean Peter
AU  - Johnson SP
AD  - UCL Cancer Institute, London, UK.
FAU - Siow, Bernard M
AU  - Siow BM
AD  - UCL Centre for Advanced Biomedical Imaging, Division of Medicine, London, UK.
FAU - Richardson, Simon
AU  - Richardson S
AD  - UCL Centre for Advanced Biomedical Imaging, Division of Medicine, London, UK.
FAU - Goncalves, Miguel R
AU  - Goncalves MR
AD  - UCL Centre for Advanced Biomedical Imaging, Division of Medicine, London, UK.
FAU - Pendse, Douglas
AU  - Pendse D
AD  - University College Hospital, London, UK.
FAU - Robinson, Simon P
AU  - Robinson SP
AD  - Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton,
      Surrey, UK.
FAU - Pedley, R Barbara
AU  - Pedley RB
AD  - UCL Cancer Institute, London, UK.
FAU - Lythgoe, Mark F
AU  - Lythgoe MF
AD  - UCL Centre for Advanced Biomedical Imaging, Division of Medicine, London, UK.
LA  - eng
GR  - BB/E528979/1/Biotechnology and Biological Sciences Research Council/United
      Kingdom
GR  - 091763/Z/10/Z/Wellcome Trust/United Kingdom
GR  - MR/K026739/1/Medical Research Council/United Kingdom
GR  - Wellcome Trust/United Kingdom
GR  - G1001497/Medical Research Council/United Kingdom
GR  - C1519/A10331/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180109
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Colorectal Neoplasms/*blood supply/diagnostic imaging/pathology
MH  - Drug Delivery Systems
MH  - Extracellular Fluid/*physiology
MH  - Humans
MH  - *Hydrodynamics
MH  - Magnetic Resonance Imaging/*methods
MH  - Mice
MH  - Mice, Nude
MH  - Models, Biological
MH  - Neovascularization, Pathologic/pathology
MH  - Phantoms, Imaging
PMC - PMC6298581
MID - EMS80810
EDAT- 2018/01/11 06:00
MHDA- 2019/03/19 06:00
CRDT- 2018/01/11 06:00
PHST- 2017/05/26 00:00 [received]
PHST- 2017/08/18 00:00 [revised]
PHST- 2018/01/05 00:00 [accepted]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2019/03/19 06:00 [medline]
PHST- 2018/01/11 06:00 [entrez]
AID - 0008-5472.CAN-17-1546 [pii]
AID - 10.1158/0008-5472.CAN-17-1546 [doi]
PST - ppublish
SO  - Cancer Res. 2018 Apr 1;78(7):1859-1872. doi: 10.1158/0008-5472.CAN-17-1546. Epub 
      2018 Jan 9.