PMID- 29263188
OWN - NLM
STAT- In-Data-Review
LR  - 20181113
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Linking)
VI  - 27
IP  - 3
DP  - 2018 Mar
TI  - Depression, Antidepressant Use, and Breast Cancer Risk in Pre- and Postmenopausal
      Women: A Prospective Cohort Study.
PG  - 306-314
LID - 10.1158/1055-9965.EPI-17-0707 [doi]
AB  - Background: Depression and antidepressant use is highly prevalent among U.S.
      women and may be related to increased breast cancer risk. However, prior studies 
      are not in agreement regarding an increase in risk.Methods: We conducted a
      prospective cohort study within the Nurses' Health Study (NHS) and NHSII among
      females age 25 and older. Over more than 10 years of follow-up in each cohort,
      4,014 incident invasive breast cancers were diagnosed. We used Cox proportional
      hazards regressions with updating of exposures and covariates throughout
      follow-up to estimate HRs and 95% confidence intervals (CIs) for associations
      between clinical depression and antidepressant use with invasive breast cancer
      risk. Analyses were repeated separately for in situ disease, as well as
      stratified by estrogen receptor (ER) subtype and menopausal status at
      diagnosis.Results: No statistically significant associations were observed
      between clinical depression (HR for reporting >/=3 times vs. 0, 1.13; 95% CI,
      0.85-1.49) or antidepressant use (HR for reporting >/=3 times vs. 0, 0.92; 95%
      CI, 0.80-1.05) and invasive breast cancer risk in multivariable analyses.
      Likewise, we observed no significant associations between clinical depression or 
      antidepressant use and risk of in situ, ER(+), ER(-), premenopausal, or
      postmenopausal breast cancer.Conclusions: In the largest prospective study to
      date, we find no evidence that either depression or antidepressant use increase
      risk of breast cancer.Impact: The results of this study are reassuring in that
      neither depression nor antidepressant use appear to be related to subsequent
      breast cancer risk. Cancer Epidemiol Biomarkers Prev; 27(3); 306-14. (c)2017
      AACR.
CI  - (c)2017 American Association for Cancer Research.
FAU - Reeves, Katherine W
AU  - Reeves KW
AD  - Department of Biostatistics and Epidemiology, University of Massachusetts
      Amherst, Amherst, Massachusetts. kwreeves@schoolph.umass.edu.
FAU - Okereke, Olivia I
AU  - Okereke OI
AD  - Channing Division of Network Medicine, Department of Medicine, Brigham and
      Women's Hospital and Harvard Medical School, Boston, Massachusetts.
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston,
      Massachusetts.
AD  - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical
      School, Boston, Massachusetts.
FAU - Qian, Jing
AU  - Qian J
AD  - Department of Biostatistics and Epidemiology, University of Massachusetts
      Amherst, Amherst, Massachusetts.
FAU - Tamimi, Rulla M
AU  - Tamimi RM
AD  - Channing Division of Network Medicine, Department of Medicine, Brigham and
      Women's Hospital and Harvard Medical School, Boston, Massachusetts.
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston,
      Massachusetts.
FAU - Eliassen, A Heather
AU  - Eliassen AH
AD  - Channing Division of Network Medicine, Department of Medicine, Brigham and
      Women's Hospital and Harvard Medical School, Boston, Massachusetts.
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston,
      Massachusetts.
FAU - Hankinson, Susan E
AU  - Hankinson SE
AD  - Department of Biostatistics and Epidemiology, University of Massachusetts
      Amherst, Amherst, Massachusetts.
AD  - Channing Division of Network Medicine, Department of Medicine, Brigham and
      Women's Hospital and Harvard Medical School, Boston, Massachusetts.
LA  - eng
GR  - R01 CA050385/CA/NCI NIH HHS/United States
GR  - P01 CA087969/CA/NCI NIH HHS/United States
GR  - UM1 CA176726/CA/NCI NIH HHS/United States
GR  - UM1 CA186107/CA/NCI NIH HHS/United States
GR  - R03 CA186228/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20171220
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American
      Association for Cancer Research, cosponsored by the American Society of
      Preventive Oncology
JID - 9200608
PMC - PMC5835185
MID - NIHMS930354
EDAT- 2017/12/22 06:00
MHDA- 2017/12/22 06:00
CRDT- 2017/12/22 06:00
PMCR- 2019/03/01 00:00
PHST- 2017/07/31 00:00 [received]
PHST- 2017/10/05 00:00 [revised]
PHST- 2017/12/14 00:00 [accepted]
PHST- 2019/03/01 00:00 [pmc-release]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2017/12/22 06:00 [medline]
PHST- 2017/12/22 06:00 [entrez]
AID - 1055-9965.EPI-17-0707 [pii]
AID - 10.1158/1055-9965.EPI-17-0707 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2018 Mar;27(3):306-314. doi:
      10.1158/1055-9965.EPI-17-0707. Epub 2017 Dec 20.