PMID- 29243858
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20180813
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Linking)
VI  - 40
IP  - 12
DP  - 2017 Dec
TI  - Atrial fibrillation and risk of cardiovascular events and mortality in patients
      with symptomatic peripheral artery disease: A meta-analysis of prospective
      studies.
PG  - 1231-1235
LID - 10.1002/clc.22813 [doi]
AB  - BACKGROUND: Atrial fibrillation (AF) is associated with adverse outcomes in terms
      of survival and morbidity. Peripheral artery disease (PAD) and AF share several
      common risk factors and often coexist. Whether AF has a prognostic role in
      patients with PAD has not been extensively studied. HYPOTHESIS: AF is associated 
      with major adverse cardiac events (MACE) and mortality in symptomatic PAD
      patients. METHODS: Using MEDLINE and Scopus, we searched for studies published
      before December 2016 that evaluated cardiovascular outcomes based on the
      presence/absence of AF in a prospective manner with a follow-up period of >/=12
      months. The outcomes were reported using a random-effects model, and
      heterogeneity was assessed using the I(2) statistic. Sensitivity analyses were
      performed to test the contribution of each study to the overall results. RESULTS:
      Six prospective studies (Newcastle-Ottawa score range, 7-9) with 14 656 patients 
      were included in the final analysis (age range, 66-70 years; median follow-up,
      1.4 years). Our pooled analysis found a significant association between AF and
      mortality (odds ratio: 2.52, 95% confidence interval: 1.91-3.34, I(2) = 32.6%),
      without evidence of publication bias (P = 0.63). Meta-analysis showed a
      significant impact of AF on MACE (odds ratio: 2.54, 95% confidence interval:
      1.78-3.63, I(2) = 74.3%), without detected publication bias (P = 0.08).
      CONCLUSIONS: AF is associated with increased risk of mortality and MACE in
      symptomatic PAD.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Vrsalovic, Mislav
AU  - Vrsalovic M
AUID- ORCID: http://orcid.org/0000-0002-8432-404X
AD  - University of Zagreb School of Medicine, Zagreb, Croatia.
AD  - Department of Cardiology, Sestre Milosrdnice University Hospital Center, Zagreb, 
      Croatia.
FAU - Presecki, Ana Vrsalovic
AU  - Presecki AV
AD  - Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb,
      Croatia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20171215
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Atrial Fibrillation/*complications/mortality
MH  - Cardiovascular Diseases/mortality
MH  - Global Health
MH  - Humans
MH  - Incidence
MH  - Odds Ratio
MH  - Peripheral Arterial Disease/*complications/epidemiology
MH  - Prospective Studies
MH  - *Risk Assessment
MH  - Risk Factors
MH  - Stroke
MH  - Survival Rate/trends
OTO - NOTNLM
OT  - Atrial Fibrillation
OT  - Cardiovascular Events
OT  - Meta-Analysis
OT  - Mortality
OT  - Peripheral Artery Disease
EDAT- 2017/12/16 06:00
MHDA- 2018/08/14 06:00
CRDT- 2017/12/16 06:00
PHST- 2017/07/12 00:00 [received]
PHST- 2017/08/25 00:00 [revised]
PHST- 2017/09/07 00:00 [accepted]
PHST- 2017/12/16 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2017/12/16 06:00 [entrez]
AID - 10.1002/clc.22813 [doi]
PST - ppublish
SO  - Clin Cardiol. 2017 Dec;40(12):1231-1235. doi: 10.1002/clc.22813. Epub 2017 Dec
      15.