PMID- 29238933
OWN - NLM
STAT- MEDLINE
DCOM- 20180824
LR  - 20181113
IS  - 1435-4373 (Electronic)
IS  - 0934-9723 (Linking)
VI  - 37
IP  - 4
DP  - 2018 Apr
TI  - Hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) from
      Pakistan: molecular characterisation by microarray technology.
PG  - 691-700
LID - 10.1007/s10096-017-3161-y [doi]
AB  - The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Pakistan 
      is known to be high, but very few studies have described the molecular
      epidemiology of the different MRSA clones circulating in the country. Forty-four 
      MRSA isolates were collected from two tertiary care hospitals of the Rawalpindi
      district of Pakistan. All strains were identified by a conventional phenotypic
      method and then subjected to genotyping by microarray hybridisation. Six clonal
      complexes (CCs) and 19 strains were identified. The most commonly identified
      strains were: (i) Panton-Valentine leucocidin (PVL)-positive CC772-MRSA-V,
      "Bengal Bay Clone" (ten isolates; 22.3%), (ii) ST239-MRSA [III + ccrC] (five
      isolates) and (iii) a CC8-MRSA-IV strain, as well as CC6-MRSA-IV (both with four 
      isolates; 9.1% each). Several of the strains detected indicated epidemiological
      links to the Middle Eastern/Arabian Gulf region. Further studies are needed to
      type MRSA from countries with less known epidemiology and to monitor the
      distribution and spread of strains, as well as possible links to global travel,
      migration and commerce.
FAU - Jamil, Bushra
AU  - Jamil B
AD  - Department of Biosciences, COMSATS Institute of Information Technology, Park
      Road, Islamabad, Pakistan.
AD  - National University of Medical Sciences (NUMS), The Mall, Rawalpindi, Pakistan.
FAU - Gawlik, Darius
AU  - Gawlik D
AD  - Abbott (Alere Technologies GmbH), Jena, Germany.
AD  - InfectoGnostics Research Campus, Jena, Germany.
FAU - Syed, Muhammad Ali
AU  - Syed MA
AD  - Department of Microbiology, University of Haripur, Haripur, Pakistan.
FAU - Shah, Asim Ali
AU  - Shah AA
AD  - Department of Pathology, Fauji Foundation Hospital, Rawalpindi, Pakistan.
FAU - Abbasi, Shahid Ahmad
AU  - Abbasi SA
AD  - Al-Sayed Hospital (Pvt) Ltd., 1-Hill Park, Opp. Ayub Park, Jhelum Road,
      Rawalpindi, Pakistan.
FAU - Muller, Elke
AU  - Muller E
AD  - Abbott (Alere Technologies GmbH), Jena, Germany.
AD  - InfectoGnostics Research Campus, Jena, Germany.
FAU - Reissig, Annett
AU  - Reissig A
AD  - Abbott (Alere Technologies GmbH), Jena, Germany.
AD  - InfectoGnostics Research Campus, Jena, Germany.
FAU - Ehricht, Ralf
AU  - Ehricht R
AD  - Abbott (Alere Technologies GmbH), Jena, Germany.
AD  - InfectoGnostics Research Campus, Jena, Germany.
FAU - Monecke, Stefan
AU  - Monecke S
AD  - Abbott (Alere Technologies GmbH), Jena, Germany. monecke@rocketmail.com.
AD  - InfectoGnostics Research Campus, Jena, Germany. monecke@rocketmail.com.
AD  - Institute for Medical Microbiology and Hygiene, Technische Universitat Dresden,
      Dresden, Germany. monecke@rocketmail.com.
LA  - eng
PT  - Journal Article
DEP - 20171214
PL  - Germany
TA  - Eur J Clin Microbiol Infect Dis
JT  - European journal of clinical microbiology & infectious diseases : official
      publication of the European Society of Clinical Microbiology
JID - 8804297
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Virulence Factors)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacology
MH  - Cross Infection/diagnosis/epidemiology/*microbiology
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Methicillin Resistance/genetics
MH  - Methicillin-Resistant Staphylococcus aureus/drug effects/*genetics/pathogenicity
MH  - Molecular Typing/*methods
MH  - Oligonucleotide Array Sequence Analysis/*methods
MH  - Pakistan/epidemiology
MH  - Prevalence
MH  - Staphylococcal Infections/diagnosis/epidemiology/*microbiology
MH  - Virulence Factors/genetics
EDAT- 2017/12/15 06:00
MHDA- 2018/08/25 06:00
CRDT- 2017/12/15 06:00
PHST- 2017/09/29 00:00 [received]
PHST- 2017/12/06 00:00 [accepted]
PHST- 2017/12/15 06:00 [pubmed]
PHST- 2018/08/25 06:00 [medline]
PHST- 2017/12/15 06:00 [entrez]
AID - 10.1007/s10096-017-3161-y [doi]
AID - 10.1007/s10096-017-3161-y [pii]
PST - ppublish
SO  - Eur J Clin Microbiol Infect Dis. 2018 Apr;37(4):691-700. doi:
      10.1007/s10096-017-3161-y. Epub 2017 Dec 14.